Results 61 to 70 of about 185,293 (312)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Complex Beauty

Complex Systems, 2015
Complex systems and their underlying convoluted networks are ubiquitous, all we need is an eye for them. They pose problems of organized complexity which cannot be approached with a reductionist method. Complexity science and its emergent sister network science both come to grips with the inherent complexity of complex systems with an holistic strategy.
openaire   +3 more sources

Asiakastyytyväisyyskysely kauneushoitola Fiina Beauty Loungelle [PDF]

, 2021
Tämän opinnäytetyön tavoitteena oli kartoittaa asiakastyytyväisyyskyselyn avulla kauneushoitola Fiina Beauty Loungen nykyistä asiakastyytyväisyyttä ja saada tietoa palveluiden kehittämiseksi. Fiina Beauty Lounge on ollut toiminnassa kolme vuotta.
Helkiö, Laura
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The measure of existence of a quantum world and the Sleeping Beauty Problem [PDF]

, 2013
An attempt to resolve the controversy regarding the solution of the Sleeping Beauty Problem in the framework of the Many-Worlds Interpretation led to a new controversy regarding the Quantum Sleeping Beauty Problem.
Vaidman, Lev, Groisman, Berry, Hallakoun, Na'ama   +2 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Pilot Study: Thread Rhinoplasty With Different Methods of Barbed Thread Implantation

Plastic and Reconstructive Surgery, Global Open
Background:. Thread rhinoplasty is a minimally invasive procedure with short downtime and high patient satisfaction. Although it is known that the effectiveness of rhinoplasty varies depending on the method of thread placement, there have been no studies
Takahiko Tamura, MD, PhD, Yoshimasa Furuichi, MD, Taichi Tamura, MD, Takashi Fuse, MD, Miku Toma, MD, Kohki Okumura, MD, Hiroo Teranishi, MD   +6 more
doaj   +1 more source

A PROPOSED TRAINING FRAMEWORK FOR THE EASTERN CAPE DEPARTMENT OF EDUCATION [PDF]

Social Sciences and Education Research Review
Effective educator performance is crucial for the success of any educational system. In the Eastern Cape Department of Education (ECDoE) faces significant challenges in ensuring consistent and high-quality performance among educators. The purpose of this
Beauty ZINDI
doaj   +1 more source

Beauty and Health: Anthropological Perspectives

, 2008
This essay, written as a ‘teaser’ for an up-coming symposium, reflects on how human beauty can be understood from an anthropological and medical anthropological perspective.
Edmonds, Alexander, Edmonds, A.
core