Results 51 to 60 of about 250,541 (308)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Suppressed B_s Decays at CDF [PDF]

, 2011
We review three recent results of the CDF collaboration on B{sub s}{sup 0} suppressed decays: the first search for CP-violation in the B{sub s}{sup 0} {yields} {phi}{phi} decay, where two CP-violating asymmetries expected to be zero in the Standard Model
DORIGO, MIRCO
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Sleeping Beauty in Quantumland [PDF]

, 2001
It is argued that thirder resolution of the Lewis - Elga controversy about Sleeping Beauty is more clear when the coin toss is replaced by a quantum measurement and the analysis is performed in the framework of the Many-Worlds ...
Vaidman, Lev
core  

The analysis of facial beauty: an emerging area of research in pattern analysis [PDF]

, 2010
Much research presented recently supports the idea that the human perception of attractiveness is data-driven and largely irrespective of the perceiver. This suggests using pattern analysis techniques for beauty analysis.
Andrea Bottino, Bottino, Andrea Giuseppe, Laurentini, Aldo, Aldo Laurentini   +3 more
core   +1 more source

The beauty of simplicity [PDF]

Communications of the ACM, 2012
As an admirer of the “artistic flare, nuanced style, and technical prowess that separates good code from great code” explored by Robert Green and Henry Ledgard [1], I was disappointed by the authors’ emphasis on “alignment, naming, use of white space, use of context, syntax highlighting, and IDE choice.” As effective as these aspects of beautiful code ...
openaire   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Natural dual inhibitor isorhamnetin-3-O-neohespeidoside targets tyrosinase and MC1R for skin pigmentation management

Scientific Reports
Skin pigmentation disorders involve complex biological regulation, with tyrosinase (TYR) and melanocortin 1 receptor (MC1R) serving as key therapeutic targets.
Rongrong Deng, Shiqian Zheng, Shengjun Xie, Gengjiu Huang, Zhiwen Ou, Zhibin Shen   +5 more
doaj   +1 more source

Investigation of Patients’ Motivation for Cosmetic Surgery in a Nationwide Cosmetic Surgery Group

Plastic and Reconstructive Surgery, Global Open
Background:. Recently, cosmetic surgeons in Japan have used social media to advertise their procedures. We analyzed the influence of social and other media on patients’ motivation to visit our clinic using the aggregated results of a questionnaire ...
Yusuke Funakoshi, MD, PhD, Masao Saito, MD, PhD, Ko Kawaguchi, MD, Eri Hiramatsu, MD, Nobuo Yamamoto, MD, Yoshiko Hondo, MD, Yumiko Nakagawa, MD, PhD, Koki Okumura, MD, Asami Sato, MD, Hiroo Teranishi, MD   +9 more
doaj   +1 more source

Clinical Application of Graphene Composite in Internal Fixation of Ankle Fracture in Sports

Advances in Materials Science and Engineering, 2022
The ankle joint consists of the tibia, the fibrous lower end, and the talus. Osteoporotic fractures and deboning are common injuries in orthopaedic surgery, often due to abnormal disorders following an ankle fracture.
Xiaowei Xu, Rongna Wang, Dachao Zhang, Yingge Feng   +3 more
doaj   +1 more source