Results 41 to 50 of about 62,296 (265)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Perancangan Rangkaian Terpadu Penguat Operasional Untuk Pengatur Nada

Jurnal EECCIS (Electrics, Electronics, Communications, Controls, Informatics, Systems), 2012
Suatu rangkaian terpadu (integrated circuit -IC) adalah sebuah kristal silikon kecil yang disebut chip mengandung komponen elektronika seperti transistor,dioda, resistor, dan kapasitor. Komponen itu saling dihubungkan dalam chip membentuk suatu rangkaian
Beauty Beauty, Agung Darmawansyah, M. Julius Setyopranoto   +2 more
doaj   +1 more source

The beauty of simplicity [PDF]

Communications of the ACM, 2012
As an admirer of the “artistic flare, nuanced style, and technical prowess that separates good code from great code” explored by Robert Green and Henry Ledgard [1], I was disappointed by the authors’ emphasis on “alignment, naming, use of white space, use of context, syntax highlighting, and IDE choice.” As effective as these aspects of beautiful code ...
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CURBING DIGITAL DIVIDE IN EDUCATION THROUGH LEVERAGING ACCESS TO DIGITAL LEARNING IN MARGINALISED COMMUNITIES IN CHRIS HANI WEST [PDF]

Social Sciences and Education Research Review
The digital divide remains a persistent challenge in South Africa’s education system, disproportionately affecting learners in rural and marginalised communities.
BEAUTY ZINDI
doaj   +1 more source

On the mathematics of beauty: beautiful images

CoRR, 2017
In this paper, we will study the simplest kind of beauty which can be found in simple visual patterns. The proposed approach shows that aesthetically appealing patterns deliver higher amount of information over multiple levels in comparison with less aesthetically appealing patterns when the same amount of energy is used.
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Demographic Data of Orbital Fat Removal for Dark Circles Under Eyes in Nationwide Cosmetic Surgery Group

Plastic and Reconstructive Surgery, Global Open
Background:. Transconjunctival orbital fat removal has exhibited an increasing trend in Japan. This study, conducted in more than 100 clinics in Japan, aimed to contribute to the evolving body of evidence guiding surgical procedures. Methods:.
Takahiko Tamura, MD, PhD, Yusuke Funakoshi, MD, PhD, Hiromichi Okuma, MD, PhD, Yoshimasa Furuichi, MD, Taichi Tamura, MD, Takashi Fuse, MD, Miku Toma, MD, Koki Okumura, MD, Hiroo Teranishi, MD   +8 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Effect of ascorbic acid on reduced glutathione level in arsenic-loaded isolated liver tissues of rat

Bangladesh Journal of Pharmacology, 2006
Isolated liver tissues of rat were loaded with trivalent arsenic and were exposed in presence and absence of ascorbic acid. The amount of reduced glutathione (GSH) in normal liver tissue was 52.0  0.2 g/g protein.
Beauty Saha
doaj   +2 more sources