Results 171 to 180 of about 24,253,925 (274)
The Complex Role of Autophagy in Cirrhosis Progression; A Call for Comprehensive Research: Letter to the Editor [PDF]
Iranian Journal of Medical SciencesWe recently have read with great interest an article entitled “The Potential Role of Autophagy in Progression of Liver Fibrosis in Chronic Hepatitis B Patients Receiving Antiviral Treatment: A Brief Report”, by Lankarani and others, which was published ...
Foolad Eghbali, Ali Jaliliyan
doaj +1 more source
Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress [PDF]
, 2019 York University ...
Jahng, James Won Suk +4 more
core +2 more sources
The role of cytokines in ovarian cancer drug resistance
International Journal of Cancer, Volume 158, Issue 4, Page 821-834, 15 February 2026.Abstract Ovarian cancer is the leading cause of death among women diagnosed with female reproductive system cancers. While significant advances have been made in treating various types of cancer, progress in ovarian cancer treatment over the past 20 years has been minimal, and the treatment course of ovarian cancer is not linear. Although many patients
Lu Wang +7 more
wiley +1 more source
Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency [PDF]
, 2013 Spinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H[superscript +]-carbohydrate transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect induces aberrant autolysosome formation that
Bayliss, Peter E. +12 more
core +4 more sources
Advanced Science, Volume 13, Issue 8, 9 February 2026.Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang +9 more
wiley +1 more source
Advanced Science, Volume 13, Issue 8, 9 February 2026.Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu +10 more
wiley +1 more source
Sex‐specific acceleration of Alzheimer's pathogenesis by chronic sleep‐deprivation
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION Sleep impairments likely contribute to Alzheimer's pathology, though specific contributions to disease progression are incompletely understood. We propose that autophagic impairment is associated with chronic sleep disruption and examine how sleep loss and stress influence disease development, including having impacts on ...
Darcy Wear +5 more
wiley +1 more source
Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease [PDF]
, 2018 The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of ...
Mack, John
core +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.β‐amyloid activates microglia via the TLR/NF‐κB pathway and primes the NLRP3 inflammasome, driving neuroinflammation. β‐asarone counteracts this by activating autophagy, which degrades NLRP3 components and inhibits inflammasome assembly. This reduces IL‐1β maturation, suppresses cytokine release, and alleviates neuronal damage and cognitive deficits in
Zhiwei Xu +6 more
wiley +1 more source