Results 171 to 180 of about 30,020,506 (258)

Beclin 1 (BECN1) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao, Wenchao Xu, Yibo Wang, Haoran Huang, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +7 more
wiley   +1 more source

Alveolar Macrophages: Development, Respiratory Homeostasis, Signal Pathways, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
Alveolar macrophages: development, respiratory homeostasis, signal pathways, diseases, and therapeutic opportunities: During embryonic development, fetal progenitors migrate to the developing lungs via a CX3CR1‐dependent mechanism to establish the TrAM pool.
Sihan Yang, Ruomeng Li, Chuanjiang Yu, Jing Li, Xikun Zhou   +4 more
wiley   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, Volume 40, Issue 10, Page 5973-5987, October 2026.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

Dose-dependent tuning of HSP70-Beclin-1 by kaempferol governs autophagy and chemosensitivity. [PDF]

Front Oncol
Hu S, Guo Y, Li M, Jin F, Luo L, Yan Z, Wang J, Liu B, Zhang Q, Luo W.   +9 more
europepmc   +1 more source

Ginsenoside Rg3 Promotes Healthy Aging Through Phosphoinositide‐Associated Lysosomal Regulation in Caenorhabditis elegans

Aging Cell, Volume 25, Issue 10, October 2026.
Ginsenoside Rg3 shifts neuronal phosphoinositide reporter signatures toward increased PI(4)P and reduced PI(3)P signals. These changes are coupled to TORC1 suppression and HLH‐30/TFEB activation, alongside restored autophagic flux and lysosomal competence, preserved neuronal proteostasis, and extended lifespan in Caenorhabditis elegans.
Haiyang Yu, Shiming Li, Yongsheng Chen, Yaoyong Zeng, Junbu Li, Yuxin Guo, Wanxiang Zhang, Lizhu Zhang, Longnong You, Kuncan Chen, Jinhong Wu, Dan Gan, Jiane‐Kang Liu, Lingjun Zheng   +13 more
wiley   +1 more source

Nuclear PI3P produced by the Beclin-1/Vps34 complex regulates DNA mismatch repair. [PDF]

Nucleic Acids Res
Li X, Vicinanza M, Lopez A, Festa BP, Schlotawa L, Barbosa AD, Takla M, Balmus G, Fleming A, Rubinsztein DC.   +9 more
europepmc   +1 more source

Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis

Andrology, Volume 14, Issue 7, Page 2329-2346, October 2026.
ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan, Nini Wei, Weiwei Ma, Mengting Hu, Bei Zhang, Li Gao, Chao Gao, Xiaoyu Yang, Yan Meng, Jiayin Liu, Yugui Cui   +10 more
wiley   +1 more source

Detection of Calpain-Mediated Beclin-1 Cleavage for Drug Discovery in Inflammatory Bowel Diseases. [PDF]

Cells
Hunter KA, Overstreet AC, Koff BB, Dharan H, Overend S, Messer JS.   +5 more
europepmc   +1 more source