Results 171 to 180 of about 31,119 (206)

Regulation of autophagy by Beclin 1 in the heart [PDF]

open access: yesJournal of Molecular and Cellular Cardiology, 2016
Dysregulation of autophagy in cardiomyocytes is implicated in various heart disease conditions. Beclin 1, a mammalian ortholog of yeast Atg6 and a core component of the autophagy machinery, plays a central role in the regulation of autophagy through activation of Vps34.
Yasuhiro Maejima, Junichi Sadoshima
exaly   +3 more sources

The Beclin 1 network regulates autophagy and apoptosis [PDF]

open access: yesCell Death and Differentiation, 2011
Beclin 1, the mammalian orthologue of yeast Atg6, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. It interacts with several cofactors (Atg14L, UVRAG, Bif-1, Rubicon, Ambra1, HMGB1, nPIST, VMP1, SLAM, IP(3)R, PINK and survivin) to regulate ...
R Kang, Dingzhong Tang, Kang R
exaly   +3 more sources

BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development [PDF]

open access: yesCell Death and Differentiation, 2008
Beclin 1/Atg6 is an essential component of the evolutionary conserved PtdIns(3)-kinase (Vps34) protein complex that regulates macroautophagy (autophagy) in eukaryotic cells and also interacts with antiapoptotic Bcl-2 family members, Bcl-2, and Bcl-x(L).
Boris M Hartmann, Stuart C Sealfon
exaly   +4 more sources

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