Results 181 to 190 of about 31,119 (206)
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Beclin-1 and LC3A expression in cutaneous malignant melanomas
Melanoma Research, 2011Autophagy is an intracellular pathway for the degradation of long-lived proteins and damaged organelles. It is, in essence, a recycling process allowing cells to survive oxygen and nutrient depletion. The expression of two autophagy-related proteins, beclin 1 and light chain 3A (LC3A) was investigated in 79 nodular cutaneous melanomas. The results were
Efthimios, Sivridis +6 more
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Regulation of macroautophagy by mTOR and Beclin 1 complexes
Biochimie, 2008Macroautophagy or autophagy is a vacuolar degradative pathway terminating in the lysosomal compartment after forming a cytoplasmic vacuole or autophagosome that engulfs macromolecules and organelles. The original discovery that ATG (AuTophaGy related) genes in yeast are involved in the formation of autophagosomes has greatly increased our knowledge of ...
Sophie, Pattingre +3 more
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Induction of autophagy and inhibition of tumorigenesis by beclin 1
Nature, 1999The process of autophagy, or bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is important in normal growth control and may be defective in tumour cells. However, little is known about the genetic mediators of autophagy in mammalian cells or their role in tumour development.
X H, Liang +6 more
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2019
Beclin 1 is the first mammalian autophagy protein identified as a novel Bcl-2-interacting protein. Subsequent studies have demonstrated that this landmark protein is essential for autophagy. By investigating the interaction between Bcl-2 and Beclin 1, key molecular mechanisms of mammalian autophagy regulation have been discovered.
Hai-Dong, Xu, Zheng-Hong, Qin
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Beclin 1 is the first mammalian autophagy protein identified as a novel Bcl-2-interacting protein. Subsequent studies have demonstrated that this landmark protein is essential for autophagy. By investigating the interaction between Bcl-2 and Beclin 1, key molecular mechanisms of mammalian autophagy regulation have been discovered.
Hai-Dong, Xu, Zheng-Hong, Qin
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Beclin 1 Complex and Neurodegenerative Disorders
2020Beclin1 is the mammalian orthologue of yeast Atg6/vacuolar protein sorting-30 (VPS30). Beclin1 interacts with various biological macromolecules like ATG14, BIF-1, NRBF2, RUBICON, UVRAG, AMBRA1, HMGB1, PINK1, and PARKIN. Such interactions promote Beclin1-PI3KC3 complex formation.
Ozaifa Kareem +5 more
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Beclin-1: Autophagic regulator and therapeutic target in cancer
The International Journal of Biochemistry & Cell Biology, 2013Beclin-1 (the mammalian ortholog of yeast ATG6) has been well-characterized to play a pivotal role in autophagy that is a major catabolic pathway in which the cell degrades macromolecules and damaged organelles. Beclin-1 structure has been identified to contain three identifiable domains, including a short Bcl-2-homology-3 (BH3) motif, a central coiled-
Lei-lei, Fu, Yan, Cheng, Bo, Liu
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Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin
Proceedings of the National Academy of Sciences of the United States of America, 2021Tobias Wijshake +2 more
exaly
The beclin 1 interactome: Modification and roles in the pathology of autophagy-related disorders
Biochimie, 2020Sargeet Kaur, Harish Changotra
exaly
Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein
Cell Research, 2012Weijiao Huang, Haiteng Deng, Lei Liu
exaly