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Regulation of macroautophagy by mTOR and Beclin 1 complexes
Biochimie, 2008Macroautophagy or autophagy is a vacuolar degradative pathway terminating in the lysosomal compartment after forming a cytoplasmic vacuole or autophagosome that engulfs macromolecules and organelles. The original discovery that ATG (AuTophaGy related) genes in yeast are involved in the formation of autophagosomes has greatly increased our knowledge of ...
Sophie, Pattingre +3 more
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Beclin-1: Autophagic regulator and therapeutic target in cancer
The International Journal of Biochemistry & Cell Biology, 2013Beclin-1 (the mammalian ortholog of yeast ATG6) has been well-characterized to play a pivotal role in autophagy that is a major catabolic pathway in which the cell degrades macromolecules and damaged organelles. Beclin-1 structure has been identified to contain three identifiable domains, including a short Bcl-2-homology-3 (BH3) motif, a central coiled-
Lei-lei, Fu, Yan, Cheng, Bo, Liu
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Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging
Nature Structural & Molecular BiologyRui Guo +10 more
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TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise
Nature, 2020Yang Liu, Xun Wang, Yuting Zhao
exaly
Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism
Cell, 2013Congcong He, Kai Sun, Xiaonan Dong
exaly