Results 191 to 200 of about 155,633 (262)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Mechanical countermeasures for spaceflight-associated neuro-ocular syndrome during 30-days of head down tilt bed rest: design, implementation, and tolerability. [PDF]

Front Physiol
Moestl S, De Boni L, Hoenemann JN, Kramer T, Schmitz J, Pesta D, Frett T, Bohmeier M, Frings-Meuthen P, Ewald AC, Nitsche A, Loehr P, Noppe A, Klischies N, Huang AS, Laurie SS, Marshall-Goebel K, Macias BR, Tank J, Jordan J, Mulder E.   +20 more
europepmc   +1 more source

3D‐Printed Metal‐Supported MOF‐Heteropoly Acid Nanozyme for High‐Performance Peroxidase‐Mimic Activity and Ultra‐Sensitive Glucose Detection

Advanced Science, EarlyView.
A hierarchically structured Fe‐BTC‐PMA immobilized 3D‐printed platform is engineered as a robust artificial enzyme for colorimetric glucose sensing. The hybrid architecture efficiently activates H2O2 to drive TMB oxidation. This integrated system enables sensitive, reusable, and scalable detection with enhanced catalytic stability and analytical ...
Paramita Koley, Ranjithkumar Jakku, Subhash Chandra Shit, Jang Mee Lee, Guy N. L. Jameson, Tayebeh Hosseinnejad, Selvakannan Periasamy, Deshetti Jampaiah, Amrit Raj Paul, Ylias Sabri, Suresh K. Bhargava   +10 more
wiley   +1 more source

Role of ultrasonography in assessing respiratory muscle loss: insights from a cross-sectional study on neurological patients with long-term bed rest with and without tracheostomy. [PDF]

BMC Pulm Med
Dong J, Xie Z, Wang W, Li Y, Li S, Zhang F, Jin L.   +6 more
europepmc   +1 more source

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

Advanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon, Dante Disharoon, Shrijal S. Desai, Baylee Traylor, Emily Gahagan, Emma Quill, Kristin Aldridge, Norman F. Luc, Sonali Rohiwal, Shruti Raghunathan, Rebecca Ahn, Sana Syed, Alexander Dornback, Bipin Chakravarthy Paruchuri, Andrew Ditto, Susan M. Shea, Philip C. Spinella, Matthew D. Neal, Michael A. Bruckman, Christa L. Pawlowski, Anirban Sen Gupta   +20 more
wiley   +1 more source

Simulated weightlessness procedure, head-down bed rest has reversible effects on the metabolism of rhesus macaque. [PDF]

Mol Brain
Li Y, Zhang X, Xu Z, Chu X, Hu Z, Ye Z, Li C, Wang Z, Zeng B, Pan J, Zhao Q, Zhou C, Lan Z, Kan G, He G, Xu X, Li W.   +16 more
europepmc   +1 more source

Feasibility and effectiveness of a foam rolling intervention in pregnant women requiring bed rest for foetal protection: a randomised controlled trial. [PDF]

BMC Pregnancy Childbirth
Gu H, Sun S, Zhang Y, Wang Y, Ding Q, Lu M, Xiang X, Sun K, Xu X.   +8 more
europepmc   +1 more source

Five days of bed rest in young and old adults: Retainment of skeletal muscle mass with neuromuscular electrical stimulation. [PDF]

Physiol Rep
Hansen SK, Hansen P, Nygaard H, Grønbæk HD, Berry TW, Olsen CM, Aagaard P, Hvid LG, Agergaard J, Dela F, Suetta C.   +10 more
europepmc   +1 more source

Assessment of the effect of 21-day head-down bed rest on the cardiovascular system by blood protein composition. [PDF]

Front Physiol
Kashirina DN, Pastushkova LK, Goncharova AG, Larina IM.   +3 more
europepmc   +1 more source