Results 101 to 110 of about 1,419,032 (336)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Effectiveness of structural-strategic family therapy in the treatment of adolescents with mental health problems and their families [PDF]

, 2019
Mental health problems during adolescence constitute a major public health concern today for both families and stakeholders. Accordingly, different family-based interventions have emerged as an effective treatment for adolescents with certain disorders ...
Baena Medina, Magdalena Sofía, Hidalgo García, María Victoria, Jiménez García, Lucía, León, Antonio, Lorence Lara, Bárbara   +4 more
core   +2 more sources

Cognitive Behavior Therapy

Medical Journal of Dr. D.Y. Patil University, 2013
Cognitive behavior therapy (CBT) theorists propose that disturbances in cognition underlie and maintain much emotional disturbance. Accordingly the cognitive addition to behavioral therapy typically consists in collaboratively noticing, restructuring, de-fusing from, and challenging these cognitions by the therapist and the patient.
Daniel Saldanha, Labanya Bhattacharya, Preethi Menon, Bhushan Chaudari   +3 more
openaire   +4 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Systematic review of psychological approaches to the management of neuropsychiatric symptoms of dementia [PDF]

, 2005
Objective: The authors systematically reviewed the literature on psychological approaches to treating the neuropsychiatric symptoms of dementia.Method: Reports of studies that examined effects of any therapy derived from a psychological approach that ...
Johnston, K, Katona, C, Livingston, G, Lyketsos, CG, Old Age Task Force World Fed, Paton, J   +5 more
core  

Pilot Testing Behavior Therapy for Chronic Tic Disorders in Neurology and Developmental Pediatrics Clinics [PDF]

, 2015
Comprehensive Behavioral Intervention for Tics (CBIT) is an efficacious treatment with limited regional availability. As neurology and pediatric clinics are often the first point of therapeutic contact for individuals with tics, the present study ...
Ely, Laura J., Gilbert, Donald L., Lipps, Tara D., Mink, Jonathan W., Piacentini, John, Ricketts, Emily J., Vierhile, Amy E., Walkup, John T., Wiegand, Geoffrey A., Woods, Douglas W., Zinner, Samuel H.   +10 more
core   +2 more sources

Mulheres, estressores no relacionamento interpessoal e seu enfrentamento [PDF]

Interpersona: An International Journal on Personal Relationships, 2010
Women are more vulnerable to the stress, and part of the stress situation comes from relationships. It has as participants 12 women in Behavior Therapy (BT).
Elizeu Borloti, Ana Carolina Marins Bezerra, Rafael Rubens de Queiroz Balbi Neto   +2 more
doaj  

A Randomized Controlled Trial Comparing Behavioral, Educational, and Pharmacological Treatments in Youths With Chronic Tic Disorder or Tourette Syndrome

Frontiers in Psychiatry, 2018
ContextThe existing literature on the treatment of pediatric chronic tic disorder (CTD) and Tourette syndrome (TS) indicates that both behavioral therapy (BT) and pharmacotherapy (PT) are effective for reducing symptoms.ObjectiveTo evaluate the efficacy ...
Renata Rizzo, Alessandra Pellico, Paola Rosaria Silvestri, Flavia Chiarotti, Francesco Cardona   +4 more
doaj   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source