Results 91 to 100 of about 284,523 (282)

Mindfulness as a treatment for gambling disorder: current directions and issues [PDF]

, 2016
Mindfulness is a form of meditation that derives from Buddhist practice and is one of the fastest growing areas of psychological research. Studies investigating the role of mindfulness in the treatment of behavioural addictions have, to date, primarily ...
Griffiths, MD, Shonin, E, Van Gordon, W
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Romantic love v.s. drug addiction may inspire a new treatment for addiction

Frontiers in Psychology, 2016
Drug addiction is a complex neurological dysfunction induced by recurring drug intoxication. Strategies to prevent and treat drug addiction constitute a topic of research interest.
Zhiling Zou, Hongwen Song, Hongwen Song, Yuting Zhang, Xiaochu Zhang, Xiaochu Zhang, Xiaochu Zhang, Xiaochu Zhang   +7 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Behavioral Addiction versus Substance Addiction: Correspondence of Psychiatric and Psychological Views

International Journal of Preventive Medicine, 2012
Introduction: Behavioral science experts believe that all entities capable of stimulating a person can be addictive; and whenever a habit changes into an obligation, it can be considered as an addiction.
Seyyed Salman Alavi, Masoud Ferdosi, Fereshte Jannatifard, Mehdi Eslami, Hamed Alaghemandan, Mehrdad Setare   +5 more
doaj  

Addiction, Adolescence, and Innate Immune Gene Induction [PDF]

, 2011
Repeated drug use/abuse amplifies psychopathology, progressively reducing frontal lobe behavioral control and cognitive flexibility while simultaneously increasing limbic temporal lobe negative emotionality.
Fulton T. Crews, Ryan Peter Vetreno
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Demographic characteristics in unplanned versus planned suicide attempts: a comparative study from Yazd, Iran

BMC Psychology
Introduction Suicide is a significant global health concern, particularly in Iran, where the rate of suicide attempts has remained high. Understanding the demographic differences between unplanned and planned suicide attempts is essential for tailoring ...
Kamyab Peyman, Shahab Ali Shirkhoda, Parvaneh Rashidpour, Reza Bidaki, Farimah Shamsi, Mohammad Nadi Sakhoidi, Golrasteh Kholasezadeh   +6 more
doaj   +1 more source

Pathologic use of video games and gotivation. Can the Gaming Motivation Scale (GAMS) predict depression and trait anxiety? [PDF]

, 2019
Videogaming is an increasingly prevalent activity among adolescents worldwide. The present study aimed at adapting the Gaming Motivation Scale (GAMS) to the Italian context, assessing its psychometric properties and verifying its sensitivity to predict ...
Curcio, Giuseppe, Peracchia, Sara, Presaghi, Fabio   +2 more
core   +1 more source