Results 91 to 100 of about 284,658 (331)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Romantic love v.s. drug addiction may inspire a new treatment for addiction

Frontiers in Psychology, 2016
Drug addiction is a complex neurological dysfunction induced by recurring drug intoxication. Strategies to prevent and treat drug addiction constitute a topic of research interest.
Zhiling Zou, Hongwen Song, Hongwen Song, Yuting Zhang, Xiaochu Zhang, Xiaochu Zhang, Xiaochu Zhang, Xiaochu Zhang   +7 more
doaj   +1 more source

Social Networking Addiction Among Hong Kong University Students: Its Health Consequences and Relationships With Parenting Behaviors [PDF]

, 2021
Lu Yu, Tingyu Luo
openalex   +1 more source

The relationship between study addiction and work addiction: a cross-cultural longitudinal study [PDF]

, 2016
Recent empirical studies investigating “study addiction” have conceptualized it as a behavioral addiction, defined within the framework of work addiction.
Andreassen, CS, Atroszko, PA, Griffiths, MD, Pallesen, S   +3 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The evolution of Internet addiction: A global perspective [PDF]

, 2015
Kimberly Young’s early work on Internet addiction (IA)has been pioneering and her early writings on the topic inspired many others to carry out research in the area.
Armstrong, Bessière, Billieux, Billieux, Billieux, Black, Brand, Brenner, Caplan, Charlton, Chou, Daria J. Kuss, Davis, Egger, Greenfield, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Griffiths, Halley M. Pontes, Joël Billieux, Kardefelt-Winther, King, Király, Kubey, Kuss, Kuss, Lavin, Leon, Mark D. Griffiths, Montag, Morahan-Martin, Orzack, Orzack, Pies, Pontes, Pratarelli, Przybylski, Scherer, Schimmenti, Shapira, Starcevic, Starcevic, Treuer, Tsai, Xuanhui, Young, Young, Young, Young, Young   +59 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Behavioral Addiction versus Substance Addiction: Correspondence of Psychiatric and Psychological Views

International Journal of Preventive Medicine, 2012
Introduction: Behavioral science experts believe that all entities capable of stimulating a person can be addictive; and whenever a habit changes into an obligation, it can be considered as an addiction.
Seyyed Salman Alavi, Masoud Ferdosi, Fereshte Jannatifard, Mehdi Eslami, Hamed Alaghemandan, Mehrdad Setare   +5 more
doaj  

Moving beyond a limited follow-up in cost-effectiveness analyses of behavioral interventions [PDF]

, 2012
Background Cost-effectiveness analyses of behavioral interventions typically use a dichotomous outcome criterion. However, achieving behavioral change is a complex process involving several steps towards a change in behavior.
Braakman-Jansen, Louise M.A., Christenhusz, Lieke C.A., Palen, Job van der, Pieterse, Marcel E., Prenger, Rilana, Seydel, Erwin R.   +5 more
core   +2 more sources