Results 101 to 110 of about 284,523 (282)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Investigando la relación entre el autocontrol, la edad y el desajuste psicológico en adolescentes y jóvenes adultos españoles [PDF]

, 2019
Este estudio explora las tendencias evolutivas en el autocontrol y su relación con el desajuste psicológico en adolescentes y jóvenes adultos. La muestra estuvo compuesta por 1,600 adolescentes y jóvenes adultos españoles de entre 12 y 34 años (M = 22.28,
Antolín Suárez, Lucía, Oliva Delgado, Alfredo, Rodríguez Meirinhos, Ana   +2 more
core   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Acute Onset of Edema Caused by Risperidone in a Schizophrenic Patient: A Case Report [PDF]

Pharmaceutical and Biomedical Research
Background: Various atypical antipsychotics have been associated with peripheral edema. The exact mechanism of creating edema is not clear yet.  Case Report: A 55-year-old woman with schizophrenia developed pedal edema after taking risperidone, which ...
Mojtaba Ahmadi, Seyed Hamzeh Hosseini
doaj  

Intense, Passionate Romantic Love: A natural addiction? How the fields that investigate romance and substance abuse can inform each other

Frontiers in Psychology, 2016
Individuals in the early stage of intense romantic love show many symptoms of substance and non-substance or behavioral addictions, including euphoria, craving, tolerance, emotional and physical dependence, withdrawal and relapse.
Helen eFisher, Xiaomeng eXu, Arthur eAron, Lucy L. Brown   +3 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Social network characteristics of COVID-19 vaccination and preventive health behaviors: Cross-sectional findings from the US northeast during the early COVID-19 pandemic

Vaccine: X
Background: The link between individuals’ vaccine attitudes and their social networks has been widely studied, but less is known about how these networks impact broader health behaviors like precautionary measures during the COVID-19 pandemic.
Aditya S. Khanna, Mollie A. Monnig, Samantha E. Clark, Peter M. Monti   +3 more
doaj   +1 more source

Internet addiction and loneliness among children and adolescents in the education setting: an empirical pilot study [PDF]

, 2014
Research into various behavioural addictions has shown that such behaviour can negatively impact psychological wellbeing. One behavioural addiction that has been increasingly studied empirically is that of Internet Addiction (IA).
Griffiths, MD, Patrão, IM, Pontes, HM
core  

A Roadmap for Integrating Neuroscience into Addiction Treatment:A Consensus of the Neuroscience Interest Group of the International Society of Addiction Medicine [PDF]

, 2019
Although there is general consensus that altered brain structure and function underpins addictive disorders, clinicians working in addiction treatment rarely incorporate neuroscience-informed approaches into their practice.
Arunogiri, Shalini, Baldacchino, Alex, Bates, Marsha E., Bowden-Jones, Henrietta, Bruno, Raimondo, Campanella, Salvatore, Daughters, Stacey, Ekhtiari, Hamed, Hester, Rob, Kouimtsidis, Christos, Lorenzetti, Valentina, Lubman, Dan I., Manning, Victoria, Meyerhoff, Dieter J., Moeller, Scott J., Paulus, Martin P., Pennington, David, Piercy, Hugh, Ralph, Annaketurah, Rezapour, Tara, Steele, Douglas, Tavakoli, Hosna, Tolomeo, Serenella, Verdejo-Garcia, Antonio, Zare-Bidoky, Mehran, Zilverstand, Anna   +25 more
core   +7 more sources