Results 101 to 110 of about 284,658 (331)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Demographic characteristics in unplanned versus planned suicide attempts: a comparative study from Yazd, Iran

BMC Psychology
Introduction Suicide is a significant global health concern, particularly in Iran, where the rate of suicide attempts has remained high. Understanding the demographic differences between unplanned and planned suicide attempts is essential for tailoring ...
Kamyab Peyman, Shahab Ali Shirkhoda, Parvaneh Rashidpour, Reza Bidaki, Farimah Shamsi, Mohammad Nadi Sakhoidi, Golrasteh Kholasezadeh   +6 more
doaj   +1 more source

Index of Problematic Online Experiences: Item Characteristics and Correlation with Negative Symptomatology [PDF]

, 2009
This exploratory study aimed to develop and test a quick, easily administered instrument, the Index of Problematic Online Experiences (I-POE). The goal of the I-POE extends beyond assessing for Internet overuse to broadly assess problematic Internet use ...
Finkelhor, David, Mitchell, Kimberly J, Sabina, Chiara, Wells, Melissa   +3 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Understanding Perceptions of Problematic Facebook Use: When People Experience Negative Life Impact and a Lack of Control

, 2019
While many people use social network sites to connect with friends and family, some feel that their use is problematic, seriously affecting their sleep, work, or life.
Biolcati Roberta, Czerwinski Mary, Jordan Alexander H, Kim Kyunghee, Kuss Daria J, Kuss Daria J, McCombs Maxwell, Social We Are, Young Kimberly S   +8 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Intense, Passionate Romantic Love: A natural addiction? How the fields that investigate romance and substance abuse can inform each other

Frontiers in Psychology, 2016
Individuals in the early stage of intense romantic love show many symptoms of substance and non-substance or behavioral addictions, including euphoria, craving, tolerance, emotional and physical dependence, withdrawal and relapse.
Helen eFisher, Xiaomeng eXu, Arthur eAron, Lucy L. Brown   +3 more
doaj   +1 more source

The Mental Health Parity and Addiction Equity Act Evaluation Study: Impact on Nonquantitative Treatment Limits for Specialty Behavioral Health Care [PDF]

, 2018
Amber Gayle Thalmayer, Jessica M. Harwood, Sarah Friedman, Francisca Azocar, Lester Watson, Haiyong Xu, Susan L. Ettner   +6 more
openalex   +1 more source

Mindfulness as a treatment for gambling disorder: current directions and issues [PDF]

, 2016
Mindfulness is a form of meditation that derives from Buddhist practice and is one of the fastest growing areas of psychological research. Studies investigating the role of mindfulness in the treatment of behavioural addictions have, to date, primarily ...
Griffiths, MD, Shonin, E, Van Gordon, W
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source