Results 101 to 110 of about 8,902,600 (289)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Frisch Demand Functions and Intertemporal Behaviour in Consumption: The Turkish Case [PDF]

This paper examines the intertemporal behaviour in consumption for Turkey which has been experiencing high and chronic inflation since the late 1970s. The Frisch demand system is used to estimate three separate but inextricably intertemporal elasticities:
Erdinc Telatar, Funda Telatar, Sadiye Turkmen   +2 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The effects of delay to reinforcement and inter-trial interval on fixed-ratio schedule performance [PDF]

, 2013
A delay to reinforcement has been found in previous studies to influence the effectiveness of a reinforcer. As the delay duration increases, response rates decrease and post reinforcement pause durations increase.
Stuart, Stacey Louisa
core  

Empiric Results from the Successful Implementation of Data-Driven Innovative Energy Services in Buildings

Buildings
The residential building sector is critical to the success of Europe’s 2030 and 2050 decarbonization targets. To achieve that success, this paper demonstrates how advanced Pay-for-Performance (P4P) energy services for energy service companies (ESCOs) can
Juan Aranda, Boniface Dominick Mselle, Juliana Cruz, Yassine Rqiq, Jose Manuel Longares   +4 more
doaj   +1 more source

A Stability Analysis of Thermostatically Controlled Loads for Power System Frequency Control

Complexity, 2017
Thermostatically controlled loads (TCLs) are a flexible demand resource with the potential to play a significant role in supporting electricity grid operation.
Ellen Webborn, Robert S. MacKay
doaj   +1 more source

"GOOD CAUSES" CROWDFUNDING AS A DRIVER FOR BEHAVIOURAL CHANGE IN DEMAND RESPONSE SCENARIOS

, 2016
The purpose of the CITYOPT Nice pilot project is to reduce domestic consumption during peak load hours, by engaging residents with demand response scenarios through a mobile app. This paper analyses the CITYOPT approach, suggesting that, when economic rewards are missing, a mix of educational activities, community involvement, social proof, and ...
Santinelli, Gabriele, Beillan, Veronique, Monteverdi, Ilaria, Jalmain, Isabelle, Decorme, Régis, Tatibouet, Marie   +5 more
openaire   +1 more source

A behaviour digital twin for residential demand response: Modelling intention and motivation to improve the prediction of the likelihood of reaction to behavioural triggers

Open Research Europe
Background: Residential demand response is a resource in the evolving energy infrastructure which thus far has not achieved its full potential. Amongst the reasons for this underutilisation is a lack of understanding, and therefore predictability, in relation to the uncertainty of the behaviour of human actors ...
Julia Blanke, Christian Beder
openaire   +1 more source