Results 91 to 100 of about 11,513 (248)

An epigenome atlas of mouse adipocytes

Molecular Metabolism
Objective: Epigenetic modifications including histone post translational modifications can influence gene expression in adipocytes, potentially contributing to metabolic dysfunctions, obesity, and insulin resistance.
Laura C. Hinte, Adhideb Ghosh, Daniel Castellano-Castillo, Christian Wolfrum, Ferdinand von Meyenn   +4 more
doaj   +1 more source

Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression

Journal of Experimental & Clinical Cancer Research, 2019
Background Emerging evidence supports the pivotal roles of adipocytes in breast cancer progression. Tumour induced beige/brown adipose tissue differentiation contributes to the hypermetabolic state of the breast cancer.
Qi Wu, Juanjuan Li, Zhiyu Li, Si Sun, Shan Zhu, Lijun Wang, Juan Wu, Jingping Yuan, Yimin Zhang, Shengrong Sun, Changhua Wang   +10 more
doaj   +1 more source

Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes. [PDF]

, 2019
Immune cells are vital constituents of the adipose microenvironment that influence both local and systemic lipid metabolism. Mice lacking IL10 have enhanced thermogenesis, but the roles of specific cell types in the metabolic response to IL10 remain to ...
Ahn, In Sook, Arneson, Douglas, Diamante, Graciel, Feng, An-Chieh, Hart, Sydney K, Lee, Stephen D, Rajbhandari, Abha K, Rajbhandari, Prashant, Reue, Karen, Santos, Luis C, Smale, Stephen T, Thomas, Brandon J, Tontonoz, Peter, Vergnes, Laurent, Yang, Xia, Zaghari, Nima   +15 more
core   +1 more source

Extracellular vesicles from adipose tissue - a potential role in obesity and type 2 diabetes? [PDF]

, 2017
Adipose tissue plays a key role in the development of insulin resistance and its pathological sequelae such as type 2 diabetes and non-alcoholic fatty liver disease. Dysfunction in the adipose tissue response to storing excess fatty acids as triglyceride
Freeman, Dilys J., Gao, Xuan, Salomon, Carlos   +2 more
core   +1 more source

Preadipocyte Uncoupling Protein 1 Expression Invoked by Fibroblast Growth Factors Imprints on Post‐Differentiation White and Brown Adipocyte Phenotype

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Primary preadipocytes from inguinal white or interscapular brown fat were treated with paracrine fibroblast growth factors (FGF) 2, 4, 8, or 9. Treatment induced acute Ucp1 expression in preadipocytes, independent of other browning markers. Upon subsequent differentiation, Ucp1 and browning markers were expressed at levels comparable to untreated cells.
Katharina Kuellmer, Carolin Mönch, Wilma Roch, Christine Wurmser, Patricia S. S. Petersen, Hildigunnur Hermannsdóttir, Mersiha Hasic, Brice Emanuelli, Tobias Fromme   +8 more
wiley   +1 more source

Maintaining mitochondria in beige adipose tissue

Adipocyte, 2019
Individual cell types vary enormously in the amount of different organelles they contain. One such organelle is the mitochondrion. Understanding how mitochondrial levels are controlled is essential since so many disease states seem to involve ...
Xiaodan Lu
doaj   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, Volume 15, Issue 10, Page 1643-1657, October 2025.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Noggin depletion in adipocytes promotes obesity in mice. [PDF]

, 2019
ObjectiveObesity has increased to pandemic levels and enhanced understanding of adipose regulation is required for new treatment strategies. Although bone morphogenetic proteins (BMPs) influence adipogenesis, the effect of BMP antagonists such as Noggin ...
Blázquez-Medela, Ana M, Boström, Kristina I, Fogelman, Alan M, Guo, Yina, Jumabay, Medet, Lusis, Aldons J, Rajbhandari, Prashant, Reue, Karen, Sallam, Tamer, Tontonoz, Peter, Vergnes, Laurent, Wu, Xiuju, Yao, Jiayi, Yao, Yucheng, Zhang, Li   +14 more
core   +1 more source

Synergistic Effects of Bioactive Compounds on Human Adiposity Mechanisms of Fat Loss and Fat Accumulation

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
Chronic diseases are associated with imbalances in adipose tissue, which plays a crucial role in regulating metabolic health. Food‐based bioactive substances (such as polyphenols, terpenoids, peptides, and fibers) impact fat metabolism by influencing the processes of lipolysis, adipogenesis, thermogenesis, and appetite control.
Mohamed Ibrahim Younis, Rawaa H. Tlay, Ammar B. Altemimi, Zheng Ruan, Tarek Gamal Abedelmaksoud   +4 more
wiley   +1 more source

Alternative isoform expression of key thermogenic genes in human beige adipocytes

Frontiers in Endocrinology
BackgroundThe beneficial effect of thermogenic adipocytes in maintaining body weight and protecting against metabolic disorders has raised interest in understanding the regulatory mechanisms defining white and beige adipocyte identity.
Sarah Hazell Pickering, Mohamed Abdelhalim, Philippe Collas, Philippe Collas, Nolwenn Briand   +4 more
doaj   +1 more source