Results 131 to 140 of about 11,513 (248)

Epigenetically active chromatin in neonatal iWAT reveals GABPα as a potential regulator of beige adipogenesis

Frontiers in Endocrinology
BackgroundThermogenic beige adipocytes, which dissipate energy as heat, are found in neonates and adults. Recent studies show that neonatal beige adipocytes are highly plastic and contribute to >50% of beige adipocytes in adults.
Raja Gopal Reddy Mooli, Bokai Zhu, Bokai Zhu, Bokai Zhu, Saifur R. Khan, Saifur R. Khan, Saifur R. Khan, Saifur R. Khan, Veerababu Nagati, Kulandaimanuvel Antony Michealraj, Michael J. Jurczak, Sadeesh K. Ramakrishnan, Sadeesh K. Ramakrishnan   +12 more
doaj   +1 more source

TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging [PDF]

, 2019
Tonicity-responsive enhancer binding protein (TonEBP or NFAT5) is a regulator of cellular adaptation to hypertonicity, macrophage activation and T-cell development. Here we report that TonEBP is an epigenetic regulator of thermogenesis and obesity.
AM Cypess, AY Kim, C Deng, C Küper, C Lopez-Rodriguez, C Postic, DP Bartel, E Kiskinis, EP Mottillo, F Hu, GS Hotamisligil, H Miyakawa, H Xie, HH Lee, HJ Yoon, I Serr, J Espada, J Symmank, J Wu, JA Dolan, JA Halterman, JH Lee, JR Arch, Jun Ho Lee, K Hotta, K Inokuma, M Buxadé, M Harms, M Kleinewietfeld, M Rosenbaum, M Uldry, MA Van Baak, N Ouchi, NR Rose, O Zierau, P Cohen, P Trayhurn, RG Baker, RT Jung, S Choi, S Schenk, SD Lee, SJ Kim, SY Choi, SY Choi, T Yoshida, TM Larsen, WY Go, X Wang   +48 more
core   +1 more source

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. [PDF]

, 2019
Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased circulating levels of BCAA are linked to obesity and diabetes.
A Balkow, A Bartelt, AM Cypess, Ayano Ueno, B Tasic, C Jang, Carlos Henrique Sponton, CB Newgard, CB Newgard, CJ Lynch, CR Green, CT Ferrara, DE Lackey, EG Sustarsic, F Palmieri, Francis C. Szoka, H Ohno, Haruya Takahashi, Hiroko Maki, Homa Majd, Huixia Li, K Ikeda, K Shinoda, Kaori Igarashi, Kazuki Tajima, KC Das, Kenji Ikeda, KH Pietiläinen, KM Huffman, Kyeongkyu Kim, LA Gilbert, Labros Sidossis, M Chondronikola, M Rosell, M Saito, M Wallace, MA Herman, Maki Ohishi, Mami Matsushita, Maria Chondronikola, Masayuki Saito, MD Neinast, Michael T. McManus, Mito Kuroda, Momoko Yoneshiro, Olga R. Ilkayeva, P She, Phillip J. White, PJ White, PJ White, Qiang Wang, Rachana N. Pradhan, Robert W. McGarrah, SH Um, Shingo Kajimura, T Li, T Soga, T Soga, T Yoneshiro, Takamasa Ishikawa, Takeshi Yoneshiro, Teruo Kawada, TJ Wang, Tomoyoshi Soga, Tsuyoshi Goto, V Ouellet, Vanille Juliette Greiner, X Kong, Yann Deleye, Yasuo Oguri, Yong Chen, Zachary Brown, Zhipeng Dai   +72 more
core   +1 more source

Epigenetic regulation of beige adipocyte fate by histone methylation

Endocrine Journal, 2019
Adipose tissue harbors plasticity to adapt to environmental thermal changes. While brown adipocyte is a thermogenic cell which produces heat acutely in response to cold stimuli, beige (or brite) adipocyte is an inducible form of thermogenic adipocytes which emerges in the white adipose depots in response to chronic cold exposure.
Tomohiro Suzuki, K. Tanimura, K. Tanimura, Diana Vargas, Takeshi Inagaki, Hiroshi Shibata   +5 more
openaire   +4 more sources

Heartbreak hotel: a convergence in cardiac regeneration [PDF]

, 2016
In February 2016, the Company of Biologists hosted an intimate gathering of leading international researchers at the forefront of experimental cardiovascular regeneration, with its emphasis on ‘Transdifferentiation and Tissue Plasticity in Cardiovascular
Schneider, MD
core   +1 more source

Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development [PDF]

, 2013
Macroautophagy (MA) regulates cellular quality control and energy balance. For example, loss of MA in aP2-positive adipocytes converts white adipose tissue (WAT) into brown adipose tissue (BAT)-like, enhancing BAT function and thereby insulin sensitivity.
Claire C Bastie, Diana Athonvarangkul, Gary J Schwartz, Haihong Zong, Jeffrey E Pessin, Luisa Coletto, Nuria Martinez‐Lopez, Rajat Singh, Srabani Sahu, Tallquist MD   +9 more
core   +2 more sources

Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice

eLife, 2017
Visceral adiposity confers significant risk for developing metabolic disease in obesity whereas preferential expansion of subcutaneous white adipose tissue (WAT) appears protective.
Chelsea Hepler, Mengle Shao, Jonathan Y Xia, Alexandra L Ghaben, Mackenzie J Pearson, Lavanya Vishvanath, Ankit X Sharma, Thomas S Morley, William L Holland, Rana K Gupta   +9 more
doaj   +1 more source

Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues

Cell Reports, 2019
Summary: Adipocyte progenitor cells (APCs) provide the reservoir of regenerative cells to produce new adipocytes, although their identity in humans remains elusive.
Arthe Raajendiran, Geraldine Ooi, Jackie Bayliss, Paul E. O’Brien, Ralf B. Schittenhelm, Ashlee K. Clark, Renea A. Taylor, Matthew S. Rodeheffer, Paul R. Burton, Matthew J. Watt   +9 more
doaj   +1 more source

ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes [PDF]

, 2014
Siegfried Ussar, Kevin Y. Lee, Simon N. Dankel, Jérémie Boucher, M Haering, André Kleinridders, Thomas Thomou, Ruidan Xue, Yazmín Macotela, Aaron M. Cypess, Yu‐Hua Tseng, Gunnar Mellgren, C. Ronald Kahn   +12 more
openalex   +1 more source

Impaired adrenergic agonist‐dependent beige adipocyte induction in aged mice [PDF]

, 2016
Woongchul Shin, Yuko Okamatsu‐Ogura, K Machida, Ayumi Tsubota, Junko Nio‐Kobayashi, Kazuhiro Kimura   +5 more
openalex   +1 more source