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RANKL induces beige adipocyte differentiation in preadipocytes
American Journal of Physiology-Endocrinology and Metabolism, 2020The receptor activator of nuclear factor-κB (NF-κB) (RANK), its ligand (RANKL), and the decoy receptor osteoprotegerin (OPG) are a triad of proteins that regulate bone metabolism, and serum OPG is considered a biomarker for cardiovascular diseases and Type 2 diabetes; however, the implications of OPG in adipose tissue metabolism remains elusive.
Flávia Sayuri Matsuo +10 more
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White and beige adipocytes: are they metabolically distinct?
Hormone Molecular Biology and Clinical Investigation, 2018Abstract The white adipose tissue (WAT) exhibits great plasticity and can undergo “browning” and acquire features of the brown adipose tissue (BAT), which takes place following cold exposure, chronic endurance exercise or β3-adrenergic stimulation.
Diane M Sepa-Kishi, Rolando B. Ceddia
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Stiffness of the extracellular matrix regulates differentiation into beige adipocytes
Biochemical and Biophysical Research Communications, 2020Beige/brite adipocytes, which express high levels of uncoupling protein 1 (UCP1) to generate heat using stored triglycerides, are induced under specific stimuli such as cold exposure in inguinal white adipose tissue (iWAT). Although extracellular microenvironments such as extracellular matrix (ECM) stiffness are known to regulate cell behaviors ...
Kyoko Takata +7 more
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A novel role for Bcl2l13 in promoting beige adipocyte biogenesis
Biochemical and Biophysical Research Communications, 2018Bcl2l13 is a member of the Bcl-2 family that has been found to play a central role in regulating apoptosis. Recently Bcl2l13 has been reported to induce mitophagy as a functional mammalian homolog of Atg32. However, the role of Bcl2l13 in adipose tissue has not been investigated yet.
Liping Ju +9 more
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A novel role for PTK2B in cultured beige adipocyte differentiation
Biochemical and Biophysical Research Communications, 2018Adipocyte differentiation is a tightly regulated process which requires the sequential and organized expression of numerous genes and proteins. Phosphorylation of cytoplasmic proteins and key transcription factors represents a critical regulatory mechanism of the process leading to adipocyte maturation and modulation of associated metabolic pathways ...
Francesco S. Celi +4 more
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A mitochondrial trigger for beige adipocyte development
Nature Reviews Endocrinology, 2022openaire +2 more sources
Beige adipocyte：a novel adipocyte
Academic Journal of Second Military Medical University, 2014An-jing Ren, Wei-ping Zhang, Kai Wang
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Nature Cell Biology, 2012 White adipocyte dysfunction and obesity-associated pathologies in humans
Nature Reviews Molecular Cell Biology, 2023Kirsty L Spalding
exaly
The cellular and functional complexity of thermogenic fat
Nature Reviews Molecular Cell Biology, 2021Paul Cohen, Shingo Kajimura
exaly