Results 61 to 70 of about 11,513 (248)

Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice

Cell Reports, 2019
Summary: Adipose tissue browning and systemic energy expenditure provide a defense mechanism against obesity and associated metabolic diseases. In high-cholesterol Western diet-fed mice, mast cell (MC) inactivation ameliorates obesity and insulin ...
Xian Zhang, Xin Wang, Hao Yin, Lei Zhang, Airong Feng, Qiu-Xia Zhang, Yan Lin, Bin Bao, Laura L. Hernandez, Guo-Ping Shi, Jian Liu   +10 more
doaj   +1 more source

Human abdominal subcutaneous-derived active beige adipocytes carrying FTO rs1421085 obesity-risk alleles exert lower thermogenic capacity

Frontiers in Cell and Developmental Biology, 2023
Introduction: White adipocytes store lipids, have a large lipid droplet and few mitochondria. Brown and beige adipocytes, which produce heat, are characterized by high expression of uncoupling protein (UCP) 1, multilocular lipid droplets, and large ...
Attila Vámos, Attila Vámos, Rini Arianti, Rini Arianti, Boglárka Ágnes Vinnai, Boglárka Ágnes Vinnai, Rahaf Alrifai, Rahaf Alrifai, Abhirup Shaw, Szilárd Póliska, Andrea Guba, Andrea Guba, Éva Csősz, István Csomós, Gábor Mocsár, Cecilia Lányi, Zoltán Balajthy, László Fésüs, Endre Kristóf   +18 more
doaj   +1 more source

Characterization of different adipose depots in fattened buffalo: histological features and expression profiling of adipocyte markers [PDF]

Archives Animal Breeding, 2020
Adipose tissue (AT) is a multi-depot organ in mammals. AT from various depots differs in composition and function. Revealing the composition feature of AT depots will provide valuable information for further research on the development and fat deposition
J. Huang, X. Liu, X. Feng, M. Zhang, K. Qu, J. Liu, X. Wei, B. Huang, Y. Ma, Y. Ma   +9 more
doaj   +1 more source

ASK1 signalling regulates brown and beige adipocyte function [PDF]

Nature Communications, 2016
AbstractRecent studies suggest that adult humans have active brown or beige adipocytes, the activation of which might be a therapeutic strategy for the treatment of diverse metabolic diseases. Here we show that the protein kinase ASK1 regulates brown and beige adipocytes function.
Shotaro Furutani, Kohki Okabe, Isao Naguro, Kazuki Hattori, Takashi Funatsu, Kohsuke Takeda, Hidenori Ichijo   +6 more
openaire   +3 more sources

Biology of Beige Adipocyte and Possible Therapy for Type 2 Diabetes and Obesity

International Journal of Endocrinology, 2016
All mammals own two main forms of fat. The classical white adipose tissue builds up energy in the form of triglycerides and is useful for preventing fatigue during periods of low caloric intake and the brown adipose tissue instead of inducing fat ...
Fernando Lizcano, Diana Vargas
doaj   +1 more source

White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming [PDF]

Pharmaceuticals
Obesity has become a pandemic, as currently more than half a billion people worldwide are obese. The etiology of obesity is multifactorial, and combines a contribution of hereditary and behavioral factors, such as nutritional inadequacy, along with the influences of environment and reduced physical activity. Two types of adipose tissue widely known are
Stanislav S. Boychenko, Vera S. Egorova, Andrew Brovin, Alexander D. Egorov   +3 more
openalex   +4 more sources

Coordinate Functional Regulation between Microsomal Prostaglandin E Synthase-1 (mPGES-1) and Peroxisome Proliferator-activated Receptor y (PPARy) in the Conversion of White-to-brown Adipocytes [PDF]

, 2017
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated nuclear receptor and a master regulator of adipogenesis. Microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is an inducible enzyme that couples with cyclooxygenase-2 for the ...
Arroyo, Vicente, Clària i Enrich, Joan, García-Alonso, Verónica, González Périz, Ana, López Vicario, Cristina, Morán-Salvador, Eva, Párrizas, Marcelina, Rius, Bibiana, Titos Rodríguez, Esther, Werz, Oliver   +9 more
core   +1 more source

Perivascular adipose tissue inflammation in vascular disease [PDF]

, 2017
Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular ...
Guzik, Tomasz J., Nosalski, Ryszard
core   +1 more source

Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism. [PDF]

, 2019
Prolonged cold exposure stimulates the recruitment of beige adipocytes within white adipose tissue. Beige adipocytes depend on mitochondrial oxidative phosphorylation to drive thermogenesis.
Lee, Sanghoon, Loft, Anne, Mandrup, Susanne, Pearson, Stephanie, Rajbhandari, Prashant, Simcox, Judith, Tontonoz, Peter, Villanueva, Claudio J   +7 more
core   +3 more sources

NRF2‐REGγ‐ACADM/KLF15 Signaling Pathway Regulates the Browning of White Adipose Tissue to Modulate Obesity

Advanced Science, EarlyView.
This study identifies that REGγ is elevated in obese adipose tissue. REGγ modulates WAT browning via ubiquitin‐independent ACADM/KLF15–UCP1 degradation. Overactivation of the NRF2–REGγ axis facilitates adipose tissue function to cause obesity. Inhibition of REGγ in the iWAT alleviates HFD‐induced obesity.
Hui Chen, Qiujing Guan, Shuangming Gong, Yingying Du, Zhidan Zhang, Yan Liu, Lei Zhou, Lin Liu, Baoquan Xin, Yilan Guo, Hui Zhang, Ziyang Zhou, Tongchao Pei, Guohong Yu, Sokun Yin, Lei Li   +15 more
wiley   +1 more source