Results 61 to 70 of about 11,954 (253)

Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis

Nature Communications, 2023
Sympathetic innervation is essential for the development of functional beige fat that maintains body temperature and metabolic homeostasis, yet the molecular mechanisms controlling this innervation remain largely unknown. Here, we show that adipocyte YAP/
Xun Huang, Xinmeng Li, Hongyu Shen, Yiheng Zhao, Zhao Zhou, Yushuang Wang, Jingfei Yao, Kaili Xue, Dongmei Wu, Yifu Qiu   +9 more
doaj   +1 more source

Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice

Cell Reports, 2019
Summary: Adipose tissue browning and systemic energy expenditure provide a defense mechanism against obesity and associated metabolic diseases. In high-cholesterol Western diet-fed mice, mast cell (MC) inactivation ameliorates obesity and insulin ...
Xian Zhang, Xin Wang, Hao Yin, Lei Zhang, Airong Feng, Qiu-Xia Zhang, Yan Lin, Bin Bao, Laura L. Hernandez, Guo-Ping Shi, Jian Liu   +10 more
doaj   +1 more source

Coordinate Functional Regulation between Microsomal Prostaglandin E Synthase-1 (mPGES-1) and Peroxisome Proliferator-activated Receptor y (PPARy) in the Conversion of White-to-brown Adipocytes [PDF]

, 2017
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated nuclear receptor and a master regulator of adipogenesis. Microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is an inducible enzyme that couples with cyclooxygenase-2 for the ...
Arroyo, Vicente, Clària i Enrich, Joan, García-Alonso, Verónica, González Périz, Ana, López Vicario, Cristina, Morán-Salvador, Eva, Párrizas, Marcelina, Rius, Bibiana, Titos Rodríguez, Esther, Werz, Oliver   +9 more
core   +1 more source

Optogenetics Sheds Light on Brown and Beige Adipocytes

Journal of Cellular Signaling, 2023
Excessive food intake leads to lipid accumulation in white adipose tissue, triggering inflammation, cellular stress, insulin resistance, and metabolic syndrome. In contrast, the dynamic energy expenditure and heat generation of brown and beige adipose tissue, driven by specialized mitochondria, render it an appealing candidate for therapeutic ...
openaire   +2 more sources

Biology of Beige Adipocyte and Possible Therapy for Type 2 Diabetes and Obesity

International Journal of Endocrinology, 2016
All mammals own two main forms of fat. The classical white adipose tissue builds up energy in the form of triglycerides and is useful for preventing fatigue during periods of low caloric intake and the brown adipose tissue instead of inducing fat ...
Fernando Lizcano, Diana Vargas
doaj   +1 more source

Distinct cellular and molecular mechanisms for β3 adrenergic receptor-induced beige adipocyte formation

eLife, 2017
Beige/brite adipocytes are induced within white adipose tissues (WAT) and, when activated, consume glucose and fatty acids to produce heat. Classically, two stimuli have been used to trigger a beiging response: cold temperatures and β3-adrenergic ...
Yuwei Jiang, Daniel C Berry, Jonathan M Graff   +2 more
doaj   +1 more source

Human abdominal subcutaneous-derived active beige adipocytes carrying FTO rs1421085 obesity-risk alleles exert lower thermogenic capacity

Frontiers in Cell and Developmental Biology, 2023
Introduction: White adipocytes store lipids, have a large lipid droplet and few mitochondria. Brown and beige adipocytes, which produce heat, are characterized by high expression of uncoupling protein (UCP) 1, multilocular lipid droplets, and large ...
Attila Vámos, Attila Vámos, Rini Arianti, Rini Arianti, Boglárka Ágnes Vinnai, Boglárka Ágnes Vinnai, Rahaf Alrifai, Rahaf Alrifai, Abhirup Shaw, Szilárd Póliska, Andrea Guba, Andrea Guba, Éva Csősz, István Csomós, Gábor Mocsár, Cecilia Lányi, Zoltán Balajthy, László Fésüs, Endre Kristóf   +18 more
doaj   +1 more source

Characterization of different adipose depots in fattened buffalo: histological features and expression profiling of adipocyte markers [PDF]

Archives Animal Breeding, 2020
Adipose tissue (AT) is a multi-depot organ in mammals. AT from various depots differs in composition and function. Revealing the composition feature of AT depots will provide valuable information for further research on the development and fat deposition
J. Huang, X. Liu, X. Feng, M. Zhang, K. Qu, J. Liu, X. Wei, B. Huang, Y. Ma, Y. Ma   +9 more
doaj   +1 more source

Reduced Beige Adipogenic Potential in Subcutaneous Adipocytes Derived from Obese Chinese Individuals

Diabetes, Metabolic Syndrome and Obesity, 2020
Han Li,1,* Lin Shen,2,* Lei Zhang,3 Bing Yan,3 Tao Sun,3 Feng Guo,3 Xiao Yin1 1Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, People’s Republic of China; 2Shandong First Medical ...
Li H, Shen L, Zhang L, Yan B, Sun T, Guo F, Yin X   +6 more
doaj  

Adaptive thermogenesis in adipocytes: Is beige the new brown? [PDF]

Genes & Development, 2013
One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose tissue is a particularly appealing target for increasing energy expenditure, given its amazing capacity to transform chemical energy into heat.
Wu, Jun, Cohen, Paul, Spiegelman, Bruce M.   +2 more
openaire   +3 more sources