Results 81 to 90 of about 11,954 (253)

Impaired adrenergic agonist-dependent beige adipocyte induction in obese mice. [PDF]

J Vet Med Sci, 2019
Brown adipocytes, which exist in brown adipose tissue (BAT), are activated by adrenergic stimulation, depending on the activity of uncoupling protein 1 (UCP1). Beige adipocytes emerge from white adipose tissue (WAT) in response to chronic adrenergic stimulation.
Shin W, Okamatsu-Ogura Y, Matsuoka S, Tsubota A, Kimura K.   +4 more
europepmc   +4 more sources

GQ-16, a TZD-derived partial PPARγ agonist, induces the expression of thermogenesis- related genes in brown fat and visceral white fat and decreases visceral adiposity in obese and hyperglycemic mice [PDF]

, 2016
Background Beige adipocytes comprise a unique thermogenic cell type in the white adipose tissue (WAT) of rodents and humans, and play a critical role in energy homeostasis.
Amato, Angélica Amorim, Báo, Sônia Nair, Christ, Camila G., Coelho, Michella S., Lima, Caroline Lourenço de, Lima, Maria do Carmo Alves de, Neves, Francisco de Assis Rocha, Oliveira, Fernanda C. B., Pereira, Sidney Alcântara, Pitta, Ivan da Rocha, Pitta, Marina Galdino da Rocha, Royer, Carine, Silva, Janaina Barbosa da   +12 more
core   +3 more sources

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

EBF2 promotes the recruitment of beige adipocytes in white adipose tissue

Molecular Metabolism, 2016
Objective: The induction of beige/brite adipose cells in white adipose tissue (WAT) is associated with protection against high fat diet-induced obesity and insulin resistance in animals.
Rachel R. Stine, Suzanne N. Shapira, Hee-Woong Lim, Jeff Ishibashi, Matthew Harms, Kyoung-Jae Won, Patrick Seale   +6 more
doaj   +1 more source

Differential actions of PPAR-α and PPAR-β/δ on beige adipocyte formation: A study in the subcutaneous white adipose tissue of obese male mice. [PDF]

PLoS ONE, 2018
Obesity compromises adipocyte physiology. PPARs are essential to adipocyte plasticity, but its isolated role in the browning phenomenon is not clear. This study aimed to examine whether activation of PPAR-α or PPAR-β/δ could induce beige cell depots in ...
Tamiris Lima Rachid, Flavia Maria Silva-Veiga, Francielle Graus-Nunes, Isabele Bringhenti, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mello   +5 more
doaj   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis. [PDF]

, 2020
Cold stimuli and the subsequent activation of β-adrenergic receptor (β-AR) potently stimulate adipose tissue thermogenesis and increase whole-body energy expenditure.
Ferro, Marc D, Ikeda, Kenji, Kajimura, Shingo, Oguri, Yasuo, Poon, Ada SY, Tajima, Kazuki, Tanabe, Yuji, Thomson, Ella A, Yoneshiro, Takeshi   +8 more
core  

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans [PDF]

, 2015
Background Genomewide association studies can be used to identify disease-relevant genomic regions, but interpretation of the data is challenging. The FTO region harbors the strongest genetic association with obesity, yet the mechanistic basis of this ...
Abdennur, Nezar Alexander, Beaudry, Jacqueline L., Claussnitzer, Melina, Dankel, Simon N., Drucker, Daniel J., Glunk, Viktoria, Haugen, Christine, Hauner, Hans, Hsu, Yi-Hsiang, Hui, Chi-Chung, Kellis, Manolis, Kim, Kyoung-Han, Liu, Jannel, Mellgren, Gunnar, Meuleman, Wouter, Puviindran, Vijitha, Quon, Gerald, Sousa, Isabel S., Svensson, Per-Arne   +18 more
core   +1 more source

The skeletal muscle–adipose creatine metabolic axis: A novel paradigm for lipid metabolism reprogramming and obesity management

Experimental Physiology, EarlyView.
Abstract The global prevalence of obesity and related metabolic disorders has spurred interdisciplinary research to develop new intervention strategies. Current research is increasingly focusing on the exercise‐induced browning of white adipose tissue and the mechanisms by which it improves energy metabolism.
Yuhui Su, Na Liu, Yang Liu, Yiqun Sun, Yike Jiao   +4 more
wiley   +1 more source

Car4-positive adipocyte progenitor cells adapt to the aging environment and work as protection against ROS via glutathione metabolism

Scientific Reports
The induction of beige adipocytes is significantly reduced in aged mice due to the senescence of adipocyte progenitor cells (APCs). Recent studies have revealed the existence of beige adipocyte subtypes, suggesting that APCs comprise a heterogeneous ...
Masato Horino, Kenji Ikeda, Rei Okazaki, Yujiro Nakano, Ryo Kaneda, Ryoko Ishii, Jun Aoki, Kazunari Hara, Akira Takeuchi, Yoshihiro Niitsu, Kuniyuki Taguchi, Kuniyuki Kano, Masanori Murakami, Kazutaka Tsujimoto, Chikara Komiya, Tetsuya Yamada   +15 more
doaj   +1 more source