Results 141 to 150 of about 38,129 (248)

Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption

Cell Reports, 2019
Summary: Regulation of body temperature critically depends on thyroid hormone (TH). Recent studies revealed that TH induces browning of white adipose tissue, possibly contributing to the observed hyperthermia in hyperthyroid patients and potentially ...
Kornelia Johann, Anna Lena Cremer, Alexander W. Fischer, Markus Heine, Eva Rial Pensado, Julia Resch, Sebastian Nock, Samuel Virtue, Lisbeth Harder, Rebecca Oelkrug, Mariana Astiz, Georg Brabant, Amy Warner, Antonio Vidal-Puig, Henrik Oster, Anita Boelen, Miguel López, Joerg Heeren, Jeffrey W. Dalley, Heiko Backes, Jens Mittag   +20 more
doaj   +1 more source

Diphyllin Improves High-Fat Diet-Induced Obesity in Mice Through Brown and Beige Adipocytes

Frontiers in Endocrinology, 2020
Brown adipose tissue (BAT) and beige adipose tissue dissipate metabolic energy and mediate nonshivering thermogenesis, thereby boosting energy expenditure. Increasing the browning of BAT and beige adipose tissue is expected to be a promising strategy for
Ya-Nan Duan, Ya-Nan Duan, Xiang Ge, Hao-Wen Jiang, Hong-Jie Zhang, Yu Zhao, Jin-Long Li, Jin-Long Li, Wei Zhang, Jing-Ya Li   +9 more
doaj   +1 more source

Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes. [PDF]

, 2019
Immune cells are vital constituents of the adipose microenvironment that influence both local and systemic lipid metabolism. Mice lacking IL10 have enhanced thermogenesis, but the roles of specific cell types in the metabolic response to IL10 remain to ...
Ahn, In Sook, Arneson, Douglas, Diamante, Graciel, Feng, An-Chieh, Hart, Sydney K, Lee, Stephen D, Rajbhandari, Abha K, Rajbhandari, Prashant, Reue, Karen, Santos, Luis C, Smale, Stephen T, Thomas, Brandon J, Tontonoz, Peter, Vergnes, Laurent, Yang, Xia, Zaghari, Nima   +15 more
core   +1 more source

Metabolic programming of a beige adipocyte phenotype by genistein [PDF]

, 2017
Scope Promoting the development of brown or beige adipose tissue may protect against obesity and related metabolic features, and potentially underlies protective effects of genistein in mice.
Anupongsanugool, Barbatelli, Couteur, der Lans, Elabd, Green, Green, Hargreaves, Harms, Himms-Hagen, Ions, Kamiya, Kim, Kim, King, Lee, Lephart, Luo, Matsushita, Moisan, Niculescu, Ozasa, Penza, Prossnitz, Qiang, Rannikko, Sanchez-Gurmaches, Sanchez-Gurmaches, Seale, Seale, Takahashi, Torre-Villalvazo, Vitali, Wakeling, Wang, Wu, Xie, Yoneshiro, Zhang   +38 more
core   +1 more source

How Does Fat Transition from White to Beige? [PDF]

Cell Metabolism, 2017
Fischer et al. (2017) recently reported that interleukin-4 (IL-4) does not increase adipose thermogenesis and that activated macrophages do not synthesize catecholamines. These findings are unexpected because IL-4 activation of macrophages has been proposed to have a pivotal role in cold-induced thermogenesis by stimulating macrophage catecholamine ...
openaire   +3 more sources

Akebia Saponin D Targeting Ubiquitin Carboxyl‐Terminal Hydrolase 4 Promotes Peroxisome Proliferator‐Activated Receptor Gamma Deubiquitination and Activation of Brown Adipose Tissue Thermogenesis in Obesity

MedComm, Volume 6, Issue 11, November 2025.
ASD, a natural plant product screened from small molecule compound library, is an antiobesity agent in mice. ASD promotes BAT thermogenesis to inhibit body weight gain. USP4 was identified and validated as a direct molecular target of ASD. ASD‐induced thermogenesis is modulated by a USP4–PPARγ–UCP1 axis.
Lang Chen, Dong‐Hai Liu, Yu‐Xi Li, Song Yang, Wei‐Hua Jia, Liang Peng, Hong‐Lin Liu, Xing‐Bo Wang, Bing Hu, Yu‐Chen Wang, Calvin Pan, Aldons Jake Lusis, Li‐Hong Liu, Li‐Li Gong   +13 more
wiley   +1 more source

Sortilin-mediated translocation of mitochondrial ACSL1 impairs adipocyte thermogenesis and energy expenditure in male mice

Nature Communications
Beige fat activation involves a fuel switch to fatty acid oxidation following chronic cold adaptation. Mitochondrial acyl-CoA synthetase long-chain family member 1 (ACSL1) localizes in the mitochondria and plays a key role in fatty acid oxidation ...
Min Yang, Jing Ge, Yu-Lian Liu, Huan-Yu Wang, Zhi-Han Wang, Dan-Pei Li, Rui He, Yu-Yu Xie, Hong-Yan Deng, Xue-Min Peng, Wen-She Wang, Jia-Dai Liu, Zeng-Zhe Zhu, Xue-Feng Yu, Pema Maretich, Shingo Kajimura, Ru-Ping Pan, Yong Chen   +17 more
doaj   +1 more source

Dielectric properties measurements of brown and white adipose tissue in rats from 0.5 to 10 GHz [PDF]

, 2016
Brown adipose tissue (BAT) plays an important role in whole body metabolism and with appropriate stimulus could potentially mediate weight gain and insulin sensitivity.
Colebeck, E., Hood, A. Z., Maccarini, P. F., Rodrigues, Dario B., Salahi, S., Stauffer, Paul R., Topsakal, E.   +6 more
core   +2 more sources

A Framework for Evaluation of New Processing Technologies in Human Milk Banking

Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 6, November 2025.
ABSTRACT The purpose of this review was to devise a framework for validation studies to test new processing technologies in human milk banking. Human milk banks are an expanding service globally. They provide donor human milk to predominantly preterm and low‐birth‐weight infants, who represent a vulnerable population.
Vanessa Clifford, Leonie Walter, Laura D. Klein, Tong Wu, Yiting Wang, Nidhi Bansal   +5 more
wiley   +1 more source

Fighting obesity by targeting factors regulating beige adipocytes. [PDF]

, 2018
Purpose of reviewThe current review provides an update on secreted factors and mechanisms that promote a thermogenic program in beige adipocytes, and their potential roles as therapeutic targets to fight obesity.Recent findingsWe outline recent studies ...
Koliwad, Suneil K, McQueen, Allison E, Wang, Jen-Chywan   +2 more
core   +1 more source