Results 141 to 150 of about 38,179 (226)

Acyl‐CoA Binding Protein in White and Brown Adipose Tissue Is Dispensable for Systemic Energy Metabolism in Mice

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Acyl‐CoA binding protein plays a vital role in lipid metabolism by mediating the intracellular flux and utilization of long‐chain acyl‐CoAs. We generated an adipocyte‐wide ACBP knockout mouse and a brown adipose tissue‐specific ACBP knockout mouse to investigate ACBP function in adipose tissue.
M. F. Nørremark, R. Petersen, P. M. M. Ruppert, E. S. Jul, T. K. Doktor, R. Nielsen, J. F. Kappel, S. Larsen, J. W. Kornfeld, S. Mandrup, B. S. Andresen, J. Havelund, D. Neess, N. J. Færgeman   +13 more
wiley   +1 more source

Brown adipose tissue and glucose homeostasis – the link between climate change and the global rise in obesity and diabetes

Adipocyte, 2019
There is increasing evidence that the global rise in temperature is contributing to the onset of diabetes, which could be mediated by a concomitant reduction in brown fat activity.
Michael E. Symonds, Grace Farhat, Peter Aldiss, Mark Pope, Helen Budge   +4 more
doaj   +1 more source

Chronic l-menthol-induced browning of white adipose tissue hypothesis: A putative therapeutic regime for combating obesity and improving metabolic health [PDF]

, 2016
Obesity constitutes a serious global health concern reaching pandemic prevalence rates. The existence of functional brown adipose tissue (BAT) in adult humans has provoked intense research interest in the role of this metabolically active tissue in whole-
Andrade, Cl��udia Marlise Balbinotti, Boguszewski, Cesar, Carrillo, Andres E, Flouris, Andreas D, Jamurtas, Athanasios Z, Kawashita, Nair Honda, Koutedakis, Yiannis, Metsios, George S, Nadolnik, Liliya, Sakellariou, Paraskevi, Svensson, Per-Arne, Valente, Angelica   +11 more
core   +1 more source

Heart matters: How glucose‐ and lipid‐modulating drugs remodel epicardial adipose tissue accumulation, inflammatory patterns and browning

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 878-894, February 2026.
Abstract Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot located between the myocardium and the visceral pericardium, exerting direct paracrine and vasocrine effects on the heart and coronary vessels. Under physiological conditions, EAT supports myocardial energy metabolism and thermoregulation through fatty acid supply and
Elisabeth Heuboeck, Charnkamal Singh Bhogal, Markus Mandl   +2 more
wiley   +1 more source

Characterization of cold-induced remodelling reveals depot-specific differences across and within brown and white adipose tissues in mice [PDF]

, 2016
Brown and beige adipose tissues dissipate energy in the form of heat via mitochondrial uncoupling protein 1, defending against hypothermia and potentially obesity.
Atit, Aydin, Barbatelli, Barneda, Barnett, Bordicchia, Bostrom, Bukowiecki, Cannon, Cannon, Cao, Cederberg, Cinti, Cousin, Dallner, Fisher, Gautier, Gesta, Giannulis, Ishibashi, Jacobsson, Jakus, Lee, Lee, Lee, Lee, Lee, Lepper, Nakamura, Nedergaard, Nedergaard, Petrovic, Ravussin, Robidoux, Sanchez-Gurmaches, Sanchez-Gurmaches, Schulz, Seale, Seale, Shefer, Shore, Stephens, Timmons, Ukropec, Vaanholt, Vernochet, Virtue, Vitali, Waldén, Wang, Widberg, Xue, Yoo, Yu, Yu, Zhou   +55 more
core   +1 more source

Nbeal2 Inactivation Triggers Abl1 Stabilisation and Dysregulated Subcellular Localisation of the Multi‐Drug‐Resistant Protein MDR1 (ABCB1) in Mast Cells

Immunology, Volume 177, Issue 2, Page 355-369, February 2026.
(A) Proposed model for Abl1 degradation via Nbeal2. Nbeal2 interacts with Abl1 with its WDR domain. This results in proteasomal degradation by a yet unidentified ubiquitin ligase. Therefore, Nbeal2 inactivation stabilises Abl1, which supports mast cell (MC) degeneration. (B) In wt MCs, the Abl1 protein level is controlled by Nbeal2. Furthermore, Nbeal2
Raphaela Marquardt, Nico Andreas, Ronja Herrnberger, Claudia Küchler, Katrin Hornung, Bernhard Nieswandt, Marco Groth, Paul M. Jordan, Oliver Werz, Julia Drube, Sebastian Drube   +10 more
wiley   +1 more source

Marrow Adipose Tissue: Skeletal Location, Sexual Dimorphism, and Response to Sex Steroid Deficiency

Frontiers in Endocrinology, 2017
Marrow adipose tissue (MAT) is unique with respect to origin, metabolism, and function. MAT is characterized with high heterogeneity which correlates with skeletal location and bone metabolism. This fat depot is also highly sensitive to various hormonal,
Beata Lecka-Czernik, Beata Lecka-Czernik, Beata Lecka-Czernik, Lance A. Stechschulte, Lance A. Stechschulte, Piotr J. Czernik, Shermel B. Sherman, Shilong Huang, Amrei Krings   +8 more
doaj   +1 more source

Community Dynamics and Antibiotic Resistance Gene Profile of Gut Microbiota in Labeo rohita Sourced From Various Catches in Retail Fish Markets in Kolkata, India

Journal of Food Safety, Volume 46, Issue 1, February 2026.
The study compared gut microbiota and antibiotic resistance genes (ARGs) in retail Labeo rohita from local and out‐of‐state sources using molecular and NGS methods. Proteobacteria dominated both groups, with Aeromonas prevalent. Region‐specific ARGs indicate environmental influences.
Goutam Banerjee, Jayita De, Shouvik Saha, Amartya Bhattacharyya, Krishnendu Acharya, Atiskumar Chattopadhyay, Pratik Banerjee   +6 more
wiley   +1 more source

Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice.

PLoS ONE, 2019
With rapid economic development, the prevalence of obesity has increased remarkably worldwide. Obesity can induce a variety of metabolic diseases, such as atherosclerosis, diabetes, hypertension and coronary heart disease, which significantly endanger ...
Haoyu Li, Chuanhai Zhang, Junyu Liu, Wenya Xie, Wentao Xu, Fei Liang, Kunlun Huang, Xiaoyun He   +7 more
doaj   +1 more source

Rutin Maintains the Thermogenic Phenotype of Beige Adipocytes and Concomitantly Suppresses Mitophagy Against Obesity in HFD Mice

Metabolites
Background: The browning of white adipose tissue for thermogenesis is an effective strategy for combating obesity. The formation of beige adipocytes is reversible, making their maintenance a key therapeutic target.
Jianmei Li, Kexin Li, Shengnan Li, Jingxun Cui, Shuangying Zhou, Huiwen Wu   +5 more
doaj   +1 more source