Results 251 to 260 of about 72,325 (270)

Application of 23Na MRI at 7 Tesla in distinguishing IDH genotype, P53 phenotype, and Ki‐67 LI in adult‐type diffuse gliomas

open access: yesVIEW, EarlyView.
Notes: Their molecular characteristics—such as IDH genotype, P53 phenotype, and Ki‐67 labeling index—are critical determinants of treatment strategies and prognosis for patients of adult‐type diffuse gliomas. In this study, we employed 7‐tesla sodium magnetic resonance imaging (23Na MRI) and demonstrated that total sodium concentration (TSC) and ...
Letian Yuan   +9 more
wiley   +1 more source

The ChickenGTEx portal: a pan-tissue catalogue of regulatory variants shaping transcriptomic and phenotypic diversity. [PDF]

open access: yesNucleic Acids Res
Hou Y   +19 more
europepmc   +1 more source

Role of mitochondrial complex I genes in host plant expansion of Bactrocera tau (Tephritidae: Diptera) by CRISPR/Cas9 system

open access: yesInsect Science, EarlyView.
The role of 3 mitochondrial complex I gene in host expansion of Bactrocera tau was verified by CRISPR/Cas9 gene editing system. A stable homogenous strain (Btndufa7‐/‐) of B.tau was established after silencing Ndufa7. The reduced size of larvae and pupae of Ndufa7 knockout strain was first found.Then different levels of fitness and relative expression ...
Wei Shi   +3 more
wiley   +1 more source

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

open access: yesInsect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li   +5 more
wiley   +1 more source

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