Results 51 to 60 of about 470,247 (283)

The Bayes Linear Programming Language [B/D]

open access: yesJournal of Statistical Software, 2000
Bayes linear methodology provides a quantitative structure for expressing our beliefs and systematic methods for revising these beliefs given observational data.
David Wooff, Michael Goldstein
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

open access: yesFEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson   +2 more
wiley   +1 more source

Eliciting interval beliefs: An experimental study

open access: yesPLOS ONE, 2017
In this paper we study the interval scoring rule as a mechanism to elicit subjective beliefs under varying degrees of uncertainty. In our experiment, subjects forecast the termination time of a time series to be generated from a given but unknown stochastic process. Subjects gradually learn more about the underlying process over time and hence the true
Peeters, Ronald, Wolk, Leonard
openaire   +4 more sources

A Penny for Your Thoughts: A Survey of Methods for Eliciting Beliefs [PDF]

open access: yesSSRN Electronic Journal, 2013
Abstract Incentivized methods for eliciting subjective probabilities in economic experiments present the subject with risky choices that encourage truthful reporting. We discuss the most prominent elicitation methods and their underlying assumptions, provide theoretical comparisons and give a new justification for the quadratic ...
Schlag, K. H.   +2 more
openaire   +8 more sources

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

open access: yesFEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez   +4 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Coping Strategies for Sexual Problems and Sexual Dysfunction Amongst Malay Women With Breast Cancer. A Qualitative Study

open access: yesSexual Medicine, 2021
Introduction: Women’ sexuality becomes complex after breast cancer diagnosis and sexual health is highly neglected in the management of the illness. Aims: To explore the coping and strategies to overcome sexuality problems and sexual dysfunction among ...
Siti Nuryati Che Ya, MMED Fam Med   +9 more
doaj   +1 more source

Prior distribution elicitation [PDF]

open access: yes, 2007
An overview of key issues associated with the elicitation of a prior probability distribution is provided. The nature of subjective probability is discussed, and the main causes of biased assessments are identified.
Lesley Walls   +12 more
core   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

open access: yesFEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court   +3 more
wiley   +1 more source

Belief Elicitation to Populate Health Economic Models of Medical Diagnostic Devices in Development [PDF]

open access: yes, 2014
Background and Objective Bayesian methods can be used to elicit experts’ beliefs about the clinical value of healthcare technologies. This study investigates a belief–elicitation method for estimating diagnostic performance in an early stage of ...
Haakma, Wieke   +3 more
core   +1 more source

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