Results 61 to 70 of about 672,665 (262)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

An Improved Multisensor Data Fusion Method and Its Application in Fault Diagnosis

IEEE Access, 2019
A multisensor system is used to improve the ability of monitoring and tracking accuracy of an engineering system since only one sensor is not enough, whereupon, faulty diagnosis, as a typical information fusion problem which is under multisensor ...
Zhongyan Wang, Fuyuan Xiao
doaj   +1 more source

Measuring Uncertainty in the Negation Evidence for Multi-Source Information Fusion

Entropy, 2022
Dempster–Shafer evidence theory is widely used in modeling and reasoning uncertain information in real applications. Recently, a new perspective of modeling uncertain information with the negation of evidence was proposed and has attracted a lot of ...
Yongchuan Tang, Yong Chen, Deyun Zhou
doaj   +1 more source

Computing the Decomposable Entropy of Graphical Belief Function Models

, 2022
In 2018, Jiroušek and Shenoy proposed a definition of entropy for Dempster-Shafer (D-S) belief functions called decomposable entropy. Here, we provide an algorithm for computing the decomposable entropy of directed graphical D-S belief function models ...
Jiroušek, Radim
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The Maximum Deng Entropy

IEEE Access, 2019
Deng entropy has been proposed to measure the uncertainty degree of basic probability assignment in evidence theory. In this paper, the condition of the maximum of Deng entropy is discussed.
Bingyi Kang, Yong Deng
doaj   +1 more source

Multisensor Data Fusion Based on Modified Belief Entropy in Dempster–Shafer Theory for Smart Environment

IEEE Access, 2021
Multisensor data fusion is extensively used to merge data from heterogeneous sensors in a smart environment. However, sensors provide noisy and uncertain information which is a big challenge for researchers.
Ihsan Ullah, Joosang Youn, Youn-Hee Han
doaj   +1 more source

A New Uncertainty Measure in Belief Entropy Framework [PDF]

International Journal of Advanced Computer Science and Applications, 2018
Belief entropy, which represents the uncertainty measure between several pieces of evidence in the Dempster-Shafer framework, is attracting increasing interest in research. It has been used in many applications and is mainly based on the theory of evidence. To quantify uncertainty, several measures have been proposed in the literature.
Moise Digrais Mambe, Tchimou N’Takp´e, Nogbou Georges, Souleymane Oumtanaga   +3 more
openaire   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source