Results 81 to 90 of about 80,347 (250)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Novel Evidence Theory and Fuzzy Preference Approach-Based Multi-Sensor Data Fusion Technique for Fault Diagnosis

Sensors, 2017
The multi-sensor data fusion technique plays a significant role in fault diagnosis and in a variety of such applications, and the Dempster–Shafer evidence theory is employed to improve the system performance; whereas, it may generate a counter-intuitive ...
Fuyuan Xiao
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

An Improved Multisensor Data Fusion Method and Its Application in Fault Diagnosis

IEEE Access, 2019
A multisensor system is used to improve the ability of monitoring and tracking accuracy of an engineering system since only one sensor is not enough, whereupon, faulty diagnosis, as a typical information fusion problem which is under multisensor ...
Zhongyan Wang, Fuyuan Xiao
doaj   +1 more source

Free Energy Approximations for CSMA networks

, 2017
In this paper we study how to estimate the back-off rates in an idealized CSMA network consisting of $n$ links to achieve a given throughput vector using free energy approximations.
Van Houdt, Benny
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Probabilistic Reconstruction in Compressed Sensing: Algorithms, Phase Diagrams, and Threshold Achieving Matrices

, 2012
Compressed sensing is a signal processing method that acquires data directly in a compressed form. This allows one to make less measurements than what was considered necessary to record a signal, enabling faster or more precise measurement protocols in a
Bayati M Lelarge M Montanari A, Binder K, Dempster A, Donoho D, Donoho D L Javanmard A Montanari A, Donoho D L Johnstone I Montanari A, Florent Krzakala, Francois Sausset, Guo D Baron D Shamai S, Hassani S, Heskes T, Iba Y, Javanmard A Montanari A, Kabashima Y, Kabashima Y, Kabashima Y Wadayama T, Kudekar S, Kudekar S Pfister H, Kudekar S Richardson T Urbanke R, Lenka Zdeborová, Lentmaier M, Marc Mézard, Mézard M, Pearl J, Rangan S, Rangan S Fletcher A Goyal V, Seeger M W Nickisch H, Vila J P Schniter P, Wu Y Verdu S, Yedidia J, Yifan Sun, Zhang F Pfister H D   +31 more
core   +4 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source