Results 81 to 90 of about 672,665 (262)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Combine Conflicting Evidence Based on the Belief Entropy and IOWA Operator

IEEE Access, 2019
Evidence theory is widely used in information fusion. However, how to combine highly conflicting evidence is still an open issue. In this paper, a modified average method is proposed to address this issue based on the belief entropy and induced ordered ...
Ran Tao, Fuyuan Xiao
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A new belief entropy and its application in software risk analysis

INTERNATIONAL JOURNAL OF COMPUTERS COMMUNICATIONS & CONTROL, 2023
The measurement of uncertainty has been an important topic of research. In Dempster’s framework, Deng entropy serves as a reliable tool for such measurements. However, it fails to consider more comprehensive information, resulting in the loss of critical data. An improved belief entropy is proposed in this paper, which preserves all the merits of Deng
Xingyuan Chen, Yong Deng
openaire   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

A Hybrid Fuzzy Soft Sets Decision Making Method in Medical Diagnosis

IEEE Access, 2018
The existing approaches for fuzzy soft sets decision-making are mainly based on different types of level soft sets. How to deal with such kinds of fuzzy soft sets decision-making problems via decreasing the uncertainty resulting from human's subjective ...
Fuyuan Xiao
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

An Evidential Reliability Indicator-Based Fusion Rule for Dempster-Shafer Theory and its Applications in Classification

IEEE Access, 2018
Dempster-Shafer evidence theory is an important methodology for multi-source information fusion depending on its advantages in dealing with uncertain information. The classical fusion rule proposed by Dempster, however, fails to handle evidence with high
Jun Xia, Yuqiang Feng, Luning Liu, Dongjun Liu, Liguo Fei   +4 more
doaj   +1 more source

How biased are maximum entropy models? [PDF]

, 2011
Maximum entropy models have become popular statistical models in neuroscience and other areas in biology, and can be useful tools for obtaining estimates of mutual information in biological systems.
Peter E. Latham, Latham, P., Macke, Jakob H., Iain Murray, Murray, I., Murray, Iain; id_orcid, Latham, Peter E., Jakob H. Macke, Macke, J.   +8 more
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