Results 81 to 90 of about 11,846 (190)

A Review on Quantitative Process Analytical Technology for Continuous Downstream Processing of Monoclonal Antibodies

Biotechnology and Bioengineering, Volume 123, Issue 3, Page 564-581, March 2026.
ABSTRACT The competition in the biopharmaceutical market is increasing due to the market entry of biosimilars and rising costs in research and development of new drugs. Hence, continuous manufacturing gained significant attention due to its potential in reducing production cycle times and costs, as well as the possibility of real‐time release testing ...
Mariana Carvalho, Ana Cruz, Cees Haringa, Marcel Ottens, Marieke Klijn   +4 more
wiley   +1 more source

Water suppression 101 for benchtop NMR–An accessible guide and primer including fully interactive training videos

Journal of Magnetic Resonance Open
Benchtop NMR is enjoying a renaissance with numerous manufacturers bringing products to the market over the last decade. The improved accessibility, lower cost of ownership and ease of use (vs high field NMR), is attracting new users into NMR ...
Ronald Soong, William Wolff, Jacob Pellizzari, Katelyn Downey, Sarah Chen, Rajshree Ghosh Biswas, Monica Bastawrous, Benjamin Goerling, Venita Busse, Falko Busse, Colin Elliott, Agnes Haber, Alain Belguise, Myrna Simpson, Andre Simpson   +14 more
doaj   +1 more source

Two New Antibiotic Pyridones Produced by a Marine Fungus, Trichoderma sp. Strain MF106 [PDF]

, 2014
Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas.
Bin Wu, Crous, Jansen, Johannes Imhoff, Jutta Wiese, Rolf Schmaljohann, Ruiz, Vanessa Oesker, Wickerham, Yuan   +9 more
core   +2 more sources

A pH-enhanced resolution in benchtop NMR spectroscopy

The Analyst
An alternative to serial NMR measurement on a benchtop machine exploits a pH gradient along the NMR tube and mechanical sample shifting. This approach allows one to detect and characterize “pH-sensitive” peaks.
Paulina Putko, Javier A. Romero, Krzysztof Kazimierczuk   +2 more
openaire   +2 more sources

A Rapid and Sensitive Method for the Determination of Chitosan Concentration by NMR Relaxometry

Magnetic Resonance in Chemistry, Volume 64, Issue 3, Page 257-264, March 2026.
ABSTRACT A rapid, reagent‐free method for the quantification of chitosan in aqueous solutions was developed using 1H nuclear magnetic resonance (NMR) relaxometry. Transverse relaxation times (T2) of chitosan solutions (5–1000 mg/L) were measured with a Carr–Purcell–Meiboom–Gill (CPMG) sequence on a benchtop NMR relaxometer.
Marta Férová, Jiří Kalina
wiley   +1 more source

METABOLIC FINGERPRINTING OF COVID-19: BENCHTOP NMR SPECTROSCOPY FOR PRECISION DIAGNOSTICS IN HOSPITALS

Open Respiratory Archives
Introduction: COVID-19 pandemic highlighted the need for diagnostics and track respiratory diseases, especially in Intensive Care Units (ICUs). Nuclear Magnetic Resonance (NMR)-based metabolomics offers unique metabolic fingerprinting for respiratory ...
Pilar Alonso-Moreno, Antonio Ferruelo, Carolina Gotera Rivera, Raquel Murillo, Luis A. de Benito-Rodríguez, María de los Ángeles Zambrano Chacón, Raquel Herrero, Germán Peces-Barba Romero, José A. Lorente, Jose L. Izquierdo-Garcia   +9 more
doaj   +1 more source

Mayamycin, a Cytotoxic Polyketide from aStreptomycesStrain Isolated from the Marine SpongeHalichondria panicea [PDF]

, 2010
A new benz[a]anthracene derivative called mayamycin (1) was identified in cultures of Streptomyces sp. strain HB202, which was isolated from the marine sponge Halichondria panicea and selected because of its profound antibiotic activity.
Erhard, Arlette, Imhoff, Johannes F., Kajahn, Inga, Nagel, Kerstin, Ohlendorf, Birgit, Schneemann, Imke, Wiese, Jutta, Zinecker, Heidi   +7 more
core   +1 more source

Flip Angle Errors in Actual Flip Angle Imaging Using Polyvinylpyrrolidone/Water‐Based Phantoms

Magnetic Resonance in Medicine, Volume 95, Issue 3, Page 1489-1502, March 2026.
ABSTRACT Purpose The aim of this work is to report and investigate unexpected errors in actual flip angle imaging (AFI) applied to phantom fillings based on polyvinylpyrrolidone (PVP). Methods Flip angle maps of PVP/water mixtures with different PVP ratios were acquired at 3 T and 7 T using a 3D cartesian AFI. The influence of spoiling was investigated
Niklas Himburg, Max Lutz, Lorenz Mitschang, Jan Gregor Frintz, Sebastian Schmitter   +4 more
wiley   +1 more source

Dual Modality Semiconducting Polymer Nanoparticles for Use in Optical and Magnetic Resonance Imaging

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
Well‐defined dual‐modality semiconducting polymer nanoparticles composed of red‐emitting conjugated polymers functionalized with novel gadolinium‐based contrast agents have been prepared. The assemblies show a greatly enhanced relaxivity performance compared to the clinical standard, Dotarem, while offering ultrabright fluorescence, ideal for optical ...
Faysal A. Farah, Yu Qin, Xin Shi, Dylan M. Owen, Mark A. Green, James D. E. T. Wilton‐Ely   +5 more
wiley   +1 more source

Further Insights Into the Metabolism of LGD‐4033 in Human Urine. Part 1. Structure Elucidation of Additional Important Metabolites

Drug Testing and Analysis, Volume 18, Issue 2, Page 245-259, February 2026.
Well‐characterized, chemically synthesized molecules related to LGD‐4033 metabolism were used as analytical standards for the analysis of LGD‐4033 post‐administration urine samples. This approach offered further insights into LGD‐4033 metabolism, providing solid experimental proof for the structure of important previously reported metabolites and ...
Yiannis S. Angelis, Panagiotis Sakellariou, Mario Thevis, Andreas Thomas, Michael Petrou, Emmanuel N. Pitsinos   +5 more
wiley   +1 more source