Results 1 to 10 of about 1,384,561 (311)

Benefit-risk assessment of the use of toxic botanical drugs in superiority field: a case study on Aconitum carmichaeli Debx [PDF]

Frontiers in Pharmacology
ObjectiveThe study aimed to establish a benefit-risk assessment (BRA) model utilizing multi-criteria decision analysis (MCDA), in order to evaluate the benefit-risk relationship of decoctions containing Aconitum carmichaeli Debx.
Xiaomeng Zhang, Congcong Qu, Bing Zhang, Jintao Lyv, Zhijian Lin, Xinlong Liu   +5 more
doaj   +2 more sources

Integrating environmental effects in the benefit-risk assessment of therapeutic products: a proposal and example for sustainable health and healthcare [PDF]

Frontiers in Drug Safety and Regulation
To mitigate healthcare’s unintended effects, environmental risk data such as ecotoxicity and environmental contamination need to be considered by all stakeholders in the healthcare value chain.
Emiliano Giovagnoni, Luisa Mattoli, Andrea Cossu, Vitalia Murgia   +3 more
doaj   +2 more sources

Quantitative Benefit-Risk Assessment: State of the Practice Within Industry. [PDF]

Ther Innov Regul Sci, 2021
Abstract Background Benefit–risk assessments for medicinal products and devices have advanced significantly over the past decade. The purpose of this study was to characterize the extent to which the life sciences industry is utilizing quantitative benefit–risk assessment (qBRA) methods ...
Smith MY, van Til J, DiSantostefano RL, Hauber AB, Marsh K.   +4 more
europepmc   +5 more sources

Patient preferences in the benefit–risk assessment of atopic dermatitis treatments in China: A nationwide surveyCapsule Summary [PDF]

JAAD International
Background: Understanding patient preferences is critical for patient-focused drug development, especially in chronic conditions like atopic dermatitis, where treatment benefit–risk profiles vary widely.
Jingyi Yang, MS, Yang Liu, MD, Hengjing Li, PhD, Yumei Ge, MD, PhD, Chen Yin, PhD, Yun Zhai, MD, PhD, Cong Zhao, MS, Siyuan Qian, MS, Xiaoyuan Chen, PhD, Songmei Xie, MD, PhD   +9 more
doaj   +2 more sources

First-Line Serplulimab versus Other Anti-PD-1/PD-L1 Antibodies Plus Chemotherapy for Esophageal Squamous Cell Carcinoma: A Systematic Review with Benefit-Risk Assessment via Matching-Adjusted Indirect Comparison [PDF]

Biologics: Targets & Therapy
Yi Zhu, Xiao Qi, Senmiao Ni, Wenting Qiu, Mengkai Chen Department of Biostatistics, Shanghai Henlius Biotech, Inc., Shanghai, People’s Republic of ChinaCorrespondence: Mengkai Chen, Department of Biostatistics, Shanghai Henlius Biotech, Inc., 188 Yizhou ...
Zhu Y, Qi X, Ni S, Qiu W, Chen M
doaj   +2 more sources

Qualitative methods of benefit / risk assessment

Безопасность и риск фармакотерапии, 2022
In this article authors describe some existing methods of benefit / risk assessment.
A. P. Pereverzev, A. N. Mironov, N. D. Bunyatyan, V. K. Lepakhin, B. K. Romanov   +4 more
doaj   +1 more source

Breastfeeding during infancy and consumption of fish and dairy products are associated with chlorinated persistent organic pollutants in serum from Swedish adolescents

Environmental Advances, 2022
Background: Food is considered the predominant source of human exposure to chlorinated and brominated persistent organic pollutants (POPs). Exposure and potential sources of these compounds are less studied in adolescents.
Galia Zamaratskaia, Helena Bjermo, Anna Karin Lindroos, Päivi Ruokojärvi, Panu Rantakokko, Hannu Kiviranta, Sanna Lignell   +6 more
doaj   +1 more source

The Nordic Nutrition Recommendations 2022 – food consumption and nutrient intake in the adult population of the Nordic and Baltic countries

Food & Nutrition Research, 2022
Background: Knowledge about the nutrient intakes and food consumption in the Nordic and Baltic countries is important for the formulation of dietary reference values (DRVs) and food-based dietary guidelines (FBDGs), as part of the Nordic Nutrition ...
Eva Warensjö Lemming, Tagli Pitsi
doaj   +1 more source

Vitamin D status in children and adults in Sweden: dietary intake and 25-hydroxyvitamin D concentrations in children aged 10–12 years and adults aged 18–80 years

Journal of Nutritional Science, 2020
The study aimed to estimate vitamin D intake and plasma/serum 25-hydroxyvitamin D (25(OH)D) concentrations, investigate determinants of 25(OH)D concentrations and compare two 25(OH)D assays.
Cecilia Nälsén, Wulf Becker, Monika Pearson, Peter Ridefelt, Anna Karin Lindroos, Natalia Kotova, Irene Mattisson   +6 more
doaj   +1 more source

Benefit–risk assessment of vitamin D supplementation [PDF]

Osteoporosis International, 2009
Current intake recommendations of 200 to 600 IU vitamin D per day may be insufficient for important disease outcomes reduced by vitamin D. INTRODUCTION: This study assessed the benefit of higher-dose and higher achieved 25-hydroxyvitamin D levels [25(OH)D] versus any associated risk. METHODS AND RESULTS: Based on double-blind randomized control trials (
Bischoff-Ferrari, Heike A., Shao, Andrew, Dawson-Hughes, Bess, Hathcock, John, Giovannucci, Edward, Willett, Walter   +5 more
openaire   +6 more sources