Results 121 to 130 of about 3,493,028 (307)
Risk-benefit assessments [PDF]
British Dental Journal, 2011 V. Yuvaraj +3 more
openaire +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
A Cost-Benefit Framework for the Assessment of Non-Tariff Measures in Agro-Food Trade [PDF]
This report develops a conceptual framework for the assessment of costs and benefits associated with non-tariff measures that allows an evidence-based comparative assessment of alternative regulatory approaches.
Beghin, John C. +2 more
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
The environmental impact of Swedish adolescents’ diets
Environmental Research: Food SystemsAdolescence is a critical life stage characterised by rapid development and openness to change. Habits formed during adolescence tend to progress into adulthood, making adolescents a key target group for interventions promoting long-term sustainable ...
Anna Karin Lindroos +3 more
doaj +1 more source
Cost-benefit rules for transport projects when labor supply is endogenous and taxes are distortionary [PDF]
We embed a stylized traffic model within a general equilibrium model in which labor supply is endogenous and income taxes are distortionary. Within this framework we derive simple rules for performing a cost-benefit analysis that can be applied knowing ...
Fosgerau, Mogens, Pilegaard, Ninette
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Cost–Benefit Assessment of 5G Rollout: Insights from Brazil
TelecomThis study provides a comprehensive techno-economic evaluation of the implementation of the 5G network, focusing on the southern region of Brazil. The research examines the capital expenditure (CAPEX) and operational expenditure (OPEX) associated with 5G
Julia Rech +2 more
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source