Results 11 to 20 of about 3,493,028 (307)

Analyse von Orphan-Drug-Verfahren in der frühen Nutzenbewertung: RCTs versus best-verfügbare vergleichende Evidenz

Monitor Versorgungsforschung, 2023
Zur Beurteilung der Wirksamkeit und Sicherheit eines neuen Wirkstoffes ist für die europäische Zulassungsbehörde (European Medicines Agency, EMA) die randomisierte kontrollierte Studie (RCT) der Goldstandard.
Dr. rer. nat. Gerrit Müller, Dr. rer. nat. Lena Fanter, Dipl.-Ges.oec. Julia Knierim   +2 more
doaj   +1 more source

Quality of clinical practice guidelines approved in Peru between 2015 and 2017

Revista de la Facultad de Medicina, 2020
Introduction: The diagnosis and management of patients with the same medical condition may vary significantly depending on the treating physician.
Oscar Steven Huapaya-Huertas, Jessica Hanae Zafra-Tanaka, Carlos Ronald Viru-Bazan, Karina Alicia Gil-Loayza, Ingrid Miluska Cruzado-Zafra, Álvaro Taype-Rondan   +5 more
doaj   +1 more source

Riksmaten Adolescents 2016–17: A national dietary survey in Sweden – design, methods, and participation

Food & Nutrition Research, 2018
Background: Nationally representative information on food consumption data is essential to evaluate dietary habits, inform policy-making and nutritional guidelines, as well as forming a basis for risk assessment and identification of risk groups ...
Lotta Moraeus, Eva Warensjö Lemming, Ulla-Kaisa Koivisto Hursti, Marianne Arnemo, Jessica Petrelius Sipinen, Anna-Karin Lindroos   +5 more
doaj   +1 more source

A machine learning approach for identifying variables associated with risk of developing neutralizing antidrug antibodies to factor VIII

Heliyon, 2023
A key unmet need in the management of hemophilia A (HA) is the lack of clinically validated markers that are associated with the development of neutralizing antibodies to Factor VIII (FVIII) (commonly referred to as inhibitors).
Atul Rawal, Christopher Kidchob, Jiayi Ou, Osman N. Yogurtcu, Hong Yang, Zuben E. Sauna   +5 more
doaj   +1 more source

Targeting mitochondrial quality control in muscle aging: Natural dietary products as potential interventions

Food Frontiers, 2023
Mitochondria are the main sources of energy production for muscle tissues, including skeletal, cardiac, or smooth muscle, to support their activities.
Qi Chen, Weisu Huang, Esra Capanoglu, Amel Thanina Amrouche, Baiyi Lu   +4 more
doaj   +1 more source

Low concentrations of perfluoroalkyl acids (PFAAs) in municipal drinking water associated with serum PFAA concentrations in Swedish adolescents

Environment International, 2023
While highly contaminated drinking water (DW) is a major source of exposure to perfluoroalkyl acids (PFAAs), the contribution of low-level contaminated DW (i.e. 
Jennifer Nyström-Kandola, Lutz Ahrens, Anders Glynn, Gunnar Johanson, Jonathan P. Benskin, Irina Gyllenhammar, Sanna Lignell, Carolina Vogs   +7 more
doaj   +1 more source

Considering Local Air Pollution in the Benefit Assessment and Cost Allocation of Cross Border Transmission Projects

Energies, 2020
Developing a regional power system to achieve a high level of integration of national systems requires sufficient development of the regional transmission grid.
Deniz Sun, Luis Olmos, Michel Rivier
doaj   +1 more source

Research on Benefit Assessment of Multi-scenario Integrated Energy System [PDF]

E3S Web of Conferences, 2023
With the rapid development of economy, China’s energy is in the stage of rapid transformation, and the market demand for comprehensive energy service in the whole society is increasing.
Liu Yujiao, Li Yan, Li Guoliang, Wang Ruiqi, Yang Le   +4 more
doaj   +1 more source

Patient-based benefit-risk assessment of medicines: development, refinement, and validation of a content search strategy to retrieve relevant studies

Journal of the Medical Library Association, 2021
Introduction: Poor indexing and inconsistent use of terms and keywords may prevent efficient retrieval of studies on the patient-based benefit-risk assessment (BRA) of medicines.
Hiba El Masri, Treasure M. McGuire, Christine Dalais, Mieke van Driel, Helen Benham, Samantha A. Hollingworth   +5 more
doaj   +1 more source

Surrogatvalidierung durch Korrelation und Surrogate Threshold Effect – Ergebnisse von Simulationsstudien

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2017
Background: Progression-free survival (PFS) is often used instead of the patient-relevant endpoint overall survival (OS) in cancer clinical trials.
Gillhaus, Johanna, Goertz, Ralf, Jeratsch, Ulli, Leverkus, Friedhelm   +3 more
doaj   +1 more source