Results 91 to 100 of about 8,561,878 (291)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Hybrid Buses: Costs and Benefits [PDF]

, 2007
Key Facts:In 2005, more than 60 percent of the 9.7 billion transit passenger trips in the United States were provided by buses, approximately 84 percent of which are powered by diesel combustion engines.Diesel exhaust contains ozone precursors, benzene ...

core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Narrative Review on the Motivational Factors And Benefits of Using Crossfit Elements in the Training of Combat Sports (Judo and Sambo)

Bulletin of the Transilvania University of Braşov: Series IX Sciences of Human Kinetics
The scientific research on using CrossFit in combat sports like judo and sambo lacks evidence, prompting further investigation. This paper aims to analyze existing literature on CrossFit and combat sports.
C. Stanciu, V. Ene-Voiciulescu
doaj   +1 more source

Information Processing Models: Benefits and Limitations [PDF]

, 2003
This paper looks at the three main information processing models from the point of view of researchers in confidential human factors databases. It explores conceptual problems with two of these information processing models, and goes on to explore ...
Davies, Professor John, Ross, Dr Alastair, Wallace, Dr Brendan   +2 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A Review of Supporting Evidence, Limitations and Challenges of Using Cover Crops in Agricultural Systems

Agriculture
Cover crops are becoming widely integrated into many farms as tools for improving sustainability. However, the decisions by growers for planting follow several objectives/criteria, many of which overlap.
Paul Cottney, Lisa Black, Ethel White, Paul N. Williams   +3 more
doaj   +1 more source

Alaska-Canada Rail Link Economic Benefits [PDF]

, 2019
Construction of the 1,740 km Alaska-Canada Rail Link (ACRL) between Fort Nelson, BC and Delta Junction, Alaska to join the North American rail system to the Alaska Railroad will result in tremendous economic benefits for Canada and the US.
Metz, Paul A., Peter Wallis Consulting Limited, Watts, Teresa   +2 more
core  

The Benefits of Physical Activity on Depression [PDF]

, 2020
Physical exercise can be an effective counter-measure against depression. Activity need not be strenuous and it may reduce the risk for depression, even among those with a family history or genetic disposition for depression. And depression in itself may
Ansello, Edward F.
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source