Results 121 to 130 of about 16,181 (141)

Closed‐Loop Recyclable Polyhexahydrotriazine Aerogels Derived From PET Waste

Small, EarlyView.
A sustainable approach for upcycling postconsumer polyethylene terephtalate (PET) into bifunctional amine monomers, which serve as building blocks for high‐performance polyhexahydrotriazine aerogels (PHT‐As), is presented. These aerogels exhibit remarkable properties, including lightweight structure, high porosity, thermal superinsulation, and ...
Christos Pantazidis, Chang‐lin Wang, Keita Saito, Yi‐Ru Chen, Željko Tomović   +4 more
wiley   +1 more source

Computation screening for incorrectly determined cocrystal structures

Acta Crystallographica Section B, Volume 81, Issue 2, Page 208-216, April 2025.
Computational salt–cocrystal differentiation, based on density functional theory improved by up‐to‐date functionals rSCAN and r2SCAN, has been tested for 404 structures. Several problematic structures have been redetermined.Pharmaceutical solid forms, like salts and cocrystals, play a crucial role in drug formulation.
Simona Chalupná, Michal Hušák, Jan Čejka, František Fňukal, Jiří Klimeš   +4 more
wiley   +1 more source

Synthetic pathway of 2-fluoro-N,N-diphenylbenzamide with opto-electrical properties: NMR, FT-IR, UV-Vis spectroscopic, and DFT computational studies of the first-order nonlinear optical organic single crystal

Green Processing and Synthesis, 2022
Raveendiran C., Prabukanthan P., Madhavan J., Vivekanand P. A., Arumugam Natarajan, Almansour Abdulrahman I., Kumar Raju Suresh, Alaqeel Shatha Ibrahim, Perumal Karthikeyan   +8 more
doaj   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

An adamantane‐based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation

The FEBS Journal, EarlyView.
Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a cationic thermosensory channel crucial for cold sensation and menthol response. TRPM8 dysfunction leads to sensory symptoms such as cold allodynia. Targeting TRPM8 is important for treating diseases like peripheral neuropathies and cancer.
Angela Lamberti, Silvio Aprile, David Cabañero, Fabio Travagin, Laura Butron, Gregorio Fernández‐Ballester, Gian Cesare Tron, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel, Ubaldina Galli   +9 more
wiley   +1 more source

High performance mixed bisimide resins and composites based thereon [PDF]

, 1986
Mixtures of bismaleimide/biscitraconirnide resins produces materials which have better handling, processing or mechanical and thermal properties, particularly in graphite composites, than materials made with the individual resins. The mechanical strength
ations., Parker, J. A.
core   +1 more source

The complete absence of cytoplasmic γ‐actin results in no discernible phenotype in mice or primary fibroblasts

The FEBS Journal, EarlyView.
Mice and mouse embryonic fibroblasts homozygous for an Actg1 allele edited to translate β‐actin instead of γ‐actin (Actg1‐coding beta) are devoid of γ‐actin protein. We demonstrate that these Actg1c‐b/c‐b mice present with no measurable phenotype in survival, body mass, activity, muscle contractility, or auditory function.
Lauren J. Sundby, Katelin M. Hawbaker, Jacob Powers, William M. Southern, Erynn E. Johnson, Xiaobai Patrinostro, Benjamin J. Perrin, James M. Ervasti   +7 more
wiley   +1 more source

Inhibitory effect of oestradiol on the cardiac KV7.1/KCNE1 channel is species dependent

Experimental Physiology, EarlyView.
Abstract Oestradiol (17β‐E2) is reported to prolong the cardiac action potential duration and QT interval, in part by affecting cardiac ion channels. Previous studies found inhibiting 17β‐E2 effects on the repolarizating cardiac KV7.1/KCNE1 channel, or its native current, in heterologous expression systems or tissue from animal species.
Veronika A. Linhart, Lucas Dauga, Sara I. Liin   +2 more
wiley   +1 more source

Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology

CA: A Cancer Journal for Clinicians, EarlyView.
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari, Johnson Ung, Jeffrey W. Craig, Kallesh D. Jayappa, Ipsita Pal, David J. Feith, Thomas P. Loughran Jr, Owen A. O’Connor   +7 more
wiley   +1 more source

Targeting the Enhanced Sensitivity of Radiotherapy in Cancer: Mechanisms, Applications, and Challenges

MedComm, Volume 6, Issue 6, June 2025.
In this review, we first introduced the current application scenarios for radiotherapy in tumor treatment, the molecular mechanisms underlying anticancer effects of radiotherapy in treatment of cancer, and the side‐effects of radiotherapy. Second, we pay attention to discuss the main types of radiosensitizers and their latest applications and ...
Yuanyuan Zhao, Fangqin Tan, Jiajia Zhao, Shuchang Zhou, Yao Luo, Chen Gong   +5 more
wiley   +1 more source