Results 121 to 130 of about 24,787 (257)

Chromatin remodeling agents for cancer therapy [PDF]

, 2008
Alterations in chromatin structure profoundly influence gene expression during normal cellular homeostasis and malignant transformation. Methylation of cytosines within CpG islands located in promoter and proximal coding regions facilitates recruitment ...
Cinti, Caterina, Estenoz, Mariela, Giordano, Roberto, La Sala, Dario, Magnano, Anna   +4 more
core   +1 more source

Voraktivierung als Weg zur Anpassung der Kinetik Mechanochemischer Transformationen

Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.
Die Kinetik mechanochemischer Reaktionen kann durch die selektive Voraktivierung von Ausgangsreagenzien deutlich verändert werden, wie durch Reaktionsüberwachung mittels zeitaufgelöster in‐situ‐Pulver‐Röntgendiffraktometrie und ab initio‐Dichtefunktionaltheorie‐Simulation gezeigt wurde.
Christian Heinekamp, Tahlia M. Palmer, Dominik Al‐Sabbagh, Anastasia May, Carsten Prinz, Stefan Michalik, Adam A. L. Michalchuk, Franziska Emmerling   +7 more
wiley   +1 more source

Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[2E]-3-phenylprop-2-enoylamino}benzamides [PDF]

, 2011
Several new 2-{[2E]-3-phenylprop-2-enoylamino}benzamides 12a-s and 17t-v were synthesized by stirring in pyridine the (E)-3-(2-R1-3-R2-4-R3-phenyl)acrylic acid chlorides 11c-k and 11t-v with the appropriate anthranilamide derivatives 10a-c or the 5-iodo ...
Bai, R., Cascioferro, S., Daidone, G., DI CRISTINA, A., Grimaudo, S., Hamel, E., Maggio, B., Pipitone, R., Plescia, F., Plescia, S., Raffa, D., Raimondi, M., Tolomeo, M.   +12 more
core   +1 more source

Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors

Metabolites, 2018
A series of benzamides incorporating 4-sulfamoyl moieties were obtained by reacting 4-sulfamoyl benzoic acid with primary and secondary amines and amino acids. These sulfonamides were investigated as inhibitors of the metalloenzyme carbonic anhydrase (CA,
Morteza Abdoli, Murat Bozdag, Andrea Angeli, Claudiu T. Supuran   +3 more
doaj   +1 more source

Pre‐Activation as a Route for Tuning the Kinetics of Mechanochemical Transformations

Angewandte Chemie International Edition, Volume 65, Issue 3, 16 January 2026.
The kinetics of mechanochemical reactions can be markedly altered through the selective pre‐activation of starting reagents, as revealed through reaction monitoring using time‐resolved in situ powder X‐ray diffraction and ab initio density functional theory simulation.
Christian Heinekamp, Tahlia M. Palmer, Dominik Al‐Sabbagh, Anastasia May, Carsten Prinz, Stefan Michalik, Adam A. L. Michalchuk, Franziska Emmerling   +7 more
wiley   +1 more source

A structural systematic study of four isomers of difluoro-N-(3-pyridyl)benzamide [PDF]

, 2009
The four isomers 2,4-, (I), 2,5-, (II), 3,4-, (III), and 3,5-difluoro-N-(3-pyridyl)benzamide, (IV), all with formula C12H8F2N2O, display molecular similarity, with interplanar angles between the C6/C5N rings ranging from 2.94 (11)° in (IV) to 4.48 (18 ...
Anderson, Frankie P., Gallagher, John F., Lough, Alan J., McMahon, Joyce   +3 more
core   +1 more source

Recent Advances in Homogeneous Catalysis with Platinum Group Pincer Complexes: Hydrogen‐Mediated Transformations and Cross‐Coupling Reactions

The Chemical Record, Volume 26, Issue 1, January 10, 2026.
Platinum group pincer complexes are highly efficient catalysts. Additionally, their high activity enables challenging transformations with low catalyst loading. Herein, we summarize the most relevant advances of catalysis involving platinum group pincer complexes. The use of pincer complexes based on platinum group metals is undoubtedly one of the most
Juan S. Serrano‐García, Andrés Amaya‐Flórez, Jordi R.‐Galindo, Adrián Ruíz‐Martínez, David Morales‐Morales   +4 more
wiley   +1 more source

Synthesis, structure and properties of N-alkoxy-N-(1-pyridinium)urea salts, N-alkoxy-N-acyloxyureas and N,N-dialkoxyureas [PDF]

, 2007
N-Alkoxy-N-(1-pyridinium)urea salts 3, 4 have been prepared, the conversions of N-acetoxy-N-methoxyurea 7 into N,N-dimethoxyurea 8 and of N-n-propyloxy-N-(1-pyridinium)-N',N'-dimethylurea chloride 6 into N,N dimethoxy-N',N'-dimethylurea 11 were carried ...
Distanov, V. B., Kostyanovsky, R. G., Kravchenko, S. V., Shishkin, O. V., Shtamburg, V. G., Shtamburg, V. V., Tsygankov, A. V., Zubatyuk, R. I.   +7 more
core   +1 more source

Recent Advances in Metal‐Based Catalysts for Nitrile Hydration to Amides: Mechanistic Aspects

The Chemical Record, Volume 26, Issue 1, January 10, 2026.
Amide vital functional group plays a key role in the composition of amide‐containing compounds, including peptides, proteins, and amino acids. Demand for innovative amide derivatives grows due to their crucial role in drug development. A cost‐effective method uses metal‐catalyzed hydration of nitriles to amides.
Fatima‐Ezzahraa Essebbar, Hicham Ben El Ayouchia, Hafid Anane, Salah‐Eddine Stiriba   +3 more
wiley   +1 more source

Histone deacetylase inhibitors induce invasion of human melanoma cells in vitro via differential regulation of N-cadherin expression and RhoA activity [PDF]

, 2016
Background: Histone deacetylase inhibitors (HDACi) exert multiple cytotoxic actions on cancer cells. Currently, different synthetic HDACi are in clinical use or clinical trials; nevertheless, since both pro-invasive and anti-invasive activities have been
Andrade, Ricardo, Arluzea, Jon, Aréchaga, Juan, De Wever, Olivier, Díaz-Núñez, María, Díez-Torre, Alejandro, Silió, Margarita   +6 more
core   +4 more sources