Results 111 to 120 of about 17,013 (236)
Solid-Phase Synthesis of Tris-Benzamides as α-Helix Mimetics
, 2016 Small molecules mimicking α-helices are of great interest since numerous protein−protein interactions use helical structures at the interface. With a goal of generating libraries of α-helix mimetics, an efficient solid-phase synthetic method was ...
Jung-Mo Ahn (1863976) +1 more
core +1 more source
Heat Shock Proteins in Cancer: Mechanisms and Therapeutic Targeting
MedComm, Volume 7, Issue 9, September 2026.This review illustrates heat shock proteins (HSPs) as central regulators of cancer metabolic reprogramming. By stabilizing key metabolic enzymes and coordinating glycolysis, oxidative phosphorylation, redox homeostasis, and stress adaptation, HSPs support tumor growth, metastasis, and therapeutic resistance. Targeting HSP networks may therefore provide
Sheng Ma +5 more
wiley +1 more source
Highly mono-selective ortho-methylthiolation of benzamides via cobalt-catalyzed sp2 C–H activation
, 2018 A highly mono-selective ortho-methylthiolation of benzamides was achieved via Co-catalyzed coupling of benzamides with DMSO.
Lin Yu +6 more
core +1 more source
Nature Communications, 2017 Investigating unusual organometallic pathways may help to efficiently control product selectivity in homogeneous catalysis. Here, the authors report the hydroarylation of aromatic amides with norbornene derivatives and propose the formation of a rhodium ...
Kaname Shibata +4 more
doaj +1 more source
MSI: A Mahalanobis‐Based Molecular Similarity Index for High‐Dimensional Embeddings
Molecular Informatics, Volume 45, Issue 9, September 2026.MSI pairs continuous Mol2Vec embeddings with a covariance‐aware Mahalanobis metric (dM, θM) to overcome the ranking ties and bit‐density bias of Tanimoto fingerprints. Across five reference compounds, MSI resolves more distinct neighbors than ECFP4 + Tanimoto and its geometry tracks HOMO–LUMO gaps in QM9, despite no electronic training.
Roberto Bernal‐Jaquez +4 more
wiley +1 more source
Composition‐Dependent Changes in Solid‐State Organization of Binary Amide Molecular Solids
ChemistrySelect, Volume 11, Issue 35, 15 September 2026.Binary mixtures of N‐methylbenzamide (NMB) and acetanilide (ACA) were investigated as a simplified molecular model for binary molecular mixing. Combined spectroscopic, diffraction, and thermal analyses revealed systematic composition‐dependent variations in local molecular environments, crystalline organization, molecular packing, and thermal behavior.
Jaeyeong Choi +4 more
wiley +1 more source
SEPARATION SCIENCE PLUS, Volume 9, Issue 9, September 2026.Proposal of a new in vitro dissolution method for nitazoxanide oral suspension, addressing critical aspects of the drug solubility and chemical stability. ABSTRACT Nitazoxanide is a broad‐spectrum prodrug widely used against protozoa, helminthes, and anaerobic bacteria.
Gabriele Cavalcante Rosa +4 more
wiley +1 more source
Avoiding pitfalls when modelling ligands in macromolecular crystallography
Acta Crystallographica Section D, Volume 82, Issue 9, Page 1016-1029, September 2026.Flawed protein–ligand X‐ray structures can misdirect drug discovery based on PDB‐deposited models. This review uses publicly available PDB examples to highlight potential pitfalls, from absent ligands to incorrect chemistry, and presents a practical validation approach to improve model reliability.The determination of protein–ligand complex structures ...
Oliver S. Smart +4 more
wiley +1 more source
, 2016 A rhodium-catalyzed oxidative acylation of benzamides with aryl aldehydes via direct sp2 C–H bond cleavage is described. In the presence of [Cp*RhCl2]2, AgSbF6, and silver carbonate as an oxidant, N,N-diethyl benzamides can be effectively carbonylated to
Jong Hwan Kwak (1433773) +7 more
core +1 more source
Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators
British Journal of Pharmacology, Volume 183, Issue 17, Page 5372-5388, September 2026.Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo +6 more
wiley +1 more source