Results 121 to 130 of about 20,263 (222)

Synthesis of 2‐Aryl(alkyl)benzimidazole Hydroxamic Acids as HDAC Inhibitors with Anti‐Angiogenesis Properties

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
2‐Aryl(alkyl)benzimidazole hydroxamic acids (11‐16) are potent and selective HDAC6 inhibitors, with minimal activity against HDAC1/2, and also display anti‐angiogenic and anticancer activities. Compound 13 exhibited a GI50 of 3.9 μM against EPCs and inhibited the growth of HCT‐116, SK‐Hep‐1, and PC‐3 cells with GI50 values of 1.3, 4.2, and 7.5 μM ...
Yi‐Ting Liu, Cheng‐Ta Lai, Shih‐Wei Wang, Shan‐Chi Liu, Yi‐Lin Hwang, Yi‐Chen Tsai, Chi‐Yeh Lee, Yu‐Wei Lai, Juei‐Yu Yen, Po‐Chuan Wang, Hsueh‐Yun Lee   +10 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Novel Triazine‐Based Dual Histone Deacetylase/phosphatidylinositol 3‐kinase Inhibitors for Breast Cancer Therapy

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Breast cancer is the most frequently diagnosed malignancy and a leading cause of cancer‐related mortality among women worldwide. Triple‐negative breast cancer (TNBC) poses a major clinical challenge due to its aggressive nature, limited therapeutic options, and high propensity for drug resistance.
Lara Luzietti, Gustavo Salgado Pires, Ana Ryan, Crisamie Regidor, Matthew Hiller, Danilo Sarti, Tríona Ní Chonghaile, Pedro de Sena Murteira Pinheiro, Damir Varešlija, Daniel Alencar Rodrigues   +9 more
wiley   +1 more source

Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors

Metabolites, 2018
A series of benzamides incorporating 4-sulfamoyl moieties were obtained by reacting 4-sulfamoyl benzoic acid with primary and secondary amines and amino acids. These sulfonamides were investigated as inhibitors of the metalloenzyme carbonic anhydrase (CA,
Morteza Abdoli, Murat Bozdag, Andrea Angeli, Claudiu T. Supuran   +3 more
doaj   +1 more source

Fair and Square: Design, Synthesis and Biological Evaluations of Squaric Acid Derivatives as Novel HDAC8 Inhibitors

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Histone deacetylase 8 (HDAC8) is a clinically validated target in neuroblastoma, where isoform selective inhibition offers a strategy to suppress tumour growth while limiting off‐target toxicity. Hydroxamic acids remain the dominant zinc‐binding group (ZBG) in HDAC inhibitors but are also associated with metabolic instability, suboptimal ...
Nathan Long, Franz‐Josef Meyer‐Almes, Aleksandra Kopranovic, Stephen P. Wren   +3 more
wiley   +1 more source

Design, Synthesis and molecular docking study of hybrids of quinazolin-4(3H)-one as anticancer agents

Ars Pharmaceutica
A series of 4-(2-(4-substituted phenyl)-4-oxoquinazolin-3(4H)-yl)-N-(2-(4-fluorophenyl)-4-oxo-5-(arylidene)thiazolidin-3-yl) benzamides (VIa-n) have been synthesized by condensation of N-(2-(4-fluorophenyl)-4-oxothiazolidin-3-yl)-4-(4-oxo-2-(4 ...
Sukanya Nara, Achaiah Garlapati
doaj   +1 more source

Cp*Co(III)-Catalyzed coupling of benzamides with α,β-unsaturated carbonyl compounds: Preparation of aliphatic ketones and azepinones [PDF]

, 2018
A Cp*Co(III)-catalyzed C-H functionalization of benzamide substrates with α,β-unsaturated ketones has been optimized, providing a facile route towards aliphatic ketone products.
Ackermann, Bai, Barsu, Bunno, Carlile, Chirila, Cui, Davies, Gensch, Gutekunst, Hu, Ikemoto, Jiang, Johansson Seechurn, Kim, Kim, Kommagalla, Kommagalla, Li, Li, Li, Liu, Lu, Ma, Mandal, Manikandan, Moselage, Patil, Pototschnig, Rouquet, Schultz, Shi, Sun, Suzuki, Wan, Wang, Wang, Wei, Wencel-Delord, Yamaguchi, Yoshino, Yoshino, Yoshino, Zhang   +43 more
core   +1 more source

Nanoassemblies of an Artificial Ferric Enterobactin Analog for Biosensing Enterobacteriaceae

ChemElectroChem, Volume 13, Issue 8, 15 April 2026.
Nanoassemblies of an artificial trisamine‐based Ferric Enterobactin, analogs to natural enterobactin and ferric enterobactin, is reported as molecular recognition receptors for real‐time biosensing. The electrochemical sensors, made from the nanoassemblies of its iron(III)complex, exhibit rapid anodic peak current changes upon exposure to live cells of
Selina Laws, Ndepana Andrew, Robson L. Grosso, Matthew Carnaghi, Hemali Rathnayake   +4 more
wiley   +1 more source

Substituted Benzamides Containing Azaspiro Rings as Upregulators of Apolipoprotein A-I Transcription

Molecules, 2012
Apolipoprotein A-I (Apo A-I) is the principal protein component of high density lipoprotein (HDL), which is generally considered as a potential therapeutic target against atherosclerosis.
Bin Hong, Xiao-Jian Jia, Xiao-Fang Chen, Shu-Yi Si, Li Wang, Wei Jiang, Yuan Yang, Yu Du   +7 more
doaj   +1 more source

Electrochemical Regioselective Chalcogenocyclizations of 2‐Alkynylbenzamides in Flow

ChemElectroChem, Volume 13, Issue 8, 15 April 2026.
A sustainable electrochemical method enables regioselective 6‐endo‐dig chalcogeno‐cyclizations of ortho‐alkynylbenzamides in continuous flow. Using diphenyl diselenide as an electroactive coupling partner, the process avoids metals and stoichiometric oxidants, offering scalable access to selenium‐containing heterocycles.
Hanaa Gieman, Sagar Arepally, Thomas Wirth   +2 more
wiley   +1 more source

2-(Difluoroboryloxy)benzamide

Molbank
The title compound has been fully characterised by NMR for the first time. Fully assigned 1H and 13C NMR spectra, and the X-ray structure of two different polymorphs are presented. The polymorphs show similar molecular geometries but exhibit significantly different patterns of intermolecular interactions.
R. Alan Aitken, Hibet E. M. Akkache, David B. Cordes, Aidan P. McKay, Dorian Moreau   +4 more
openaire   +2 more sources