Results 121 to 130 of about 17,013 (236)

Rational Design, Synthesis, Biological Evaluation, and In Silico Study of N‐Cinnamamide/Benzamide‐(4‐(Substituted Phenyl)‐6‐(4‐Cyclohexylphenyl)pyrimidin‐2‐Yl) Derivatives as EGFR Inhibitors Targeting EGFRWT, EGFRT790M, and EGFRL858R/T790M/C797S in NSCLC

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
Rational Design, Synthesis, Biological Evaluation, and In Silico Investigation of N‐Cinnamamide/Benzamide‐(4‐(Substituted Phenyl)‐6‐(4‐Cyclohexylphenyl)pyrimidin‐2‐yl) Derivatives as EGFR Inhibitors Targeting Wild‐Type and Mutant EGFR in NSCLC. ABSTRACT Non‐small cell lung cancer (NSCLC), driven by mutations in the epidermal growth factor receptor ...
Rohit Pal, Gurubasavaraja Swamy Purawarga Matada, Ghanshyam Teli, Manjushree BV, Anguraj Moulishankar, Viney Chawla, Pooja A. Chawla   +6 more
wiley   +1 more source

Iso‐ and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On‐Target Activity Through Scaffold Decoration and In Situ Warhead Generation

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
We explore covalent allosteric targeting of MGL regulatory cysteines using iso‐ and benzisothiazolinone scaffolds. Combining mechanism‐based warhead release with structure‐guided scaffold decoration to improve molecular recognition, this study probes strategies to achieve selective on‐target engagement beyond the catalytic site. Monoacylglycerol lipase
Edoardo Rocca, Annalida Bedini, Laura Scalvini, Francesca Galvani, Riccardo Castelli, Lorenzo Sarcone, Adriano Recchia, Fabiola Fanini, Adren Tran, Silvia Rivara, Gilberto Spadoni, Daniele Piomelli, Marco Mor   +12 more
wiley   +1 more source

Synthesis and Evaluation of Novel Radioiodinated Benzamides for Malignant Melanoma

, 2016
The imaging potential of a series of [123I]benzamides was studied in mice bearing B16F0 melanoma tumors. Compound [123I]25 exhibited tumor uptake >8 %ID/g at 1 h, while that of [123I]14d and [123I]25 reached a maximum of 9−12 %ID/g at 6 h.
Xiang Liu (119470), Patrice Ballantyne (2351047), Janette Chapman (2483029), Filomena Mattner (2351038), Andrew Katsifis (511670), Tien Q. Pham (1550416), Branko Dikic (2483035), Ivan Greguric (1534126), Paula Berghofer (1550401), Timothy Jackson (2219299), Christian Loc' (2483032)   +10 more
core   +1 more source

Synthesis and evaluation of novel radioiodinated benzamides for malignant melanoma

, 2014
The imaging potential of a series of [123I]benzamides was studied in mice bearing B16F0 melanoma tumors. Compound [123I]25 exhibited tumor uptake >8 %ID/g at 1 h, while that of [123I]14d and [123I]25 reached a maximum of 9−12 %ID/g at 6 h.
Greguric, I, Liu, X, Mattner, F, Berghofer, PJ, Ballantyne, P, Dikic, B, Pham, TQ, Katsifis, A, Jackson, T, Chapman, J, Loc'h, C   +10 more
core   +1 more source

Synthesis of Tertiary Benzamides via Pd-Catalyzed Coupling of Arylboronic Esters and Carbamoyl Chlorides

, 2016
Ortho-substituted arylboronic esters are efficiently coupled with carbamoyl chlorides under Pd-catalysis to give tertiary ...
Jesper Langgaard Kristensen (1743049), Morten Lysén (2647174), Mikael Begtrup (1796404), Susan Kelleher (2216233)   +3 more
core   +1 more source

Torsional angles in N-substituted benzamides and related compounds by carbon-13 N.M.R. chemical shifts

, 1981
The torsional angles in 30 N-substituted benzamides and related compounds have been estimated by the use of the 13C substituent chemical shifts of the meta and para carbon atoms.
CW Fong, HG Grant
core   +1 more source

RETRACTED ARTICLE: Metal free cross-dehydrogenative N-N coupling of primary amides with Lewis basic amines

Nature Communications
Hydrazides, N-N containing structural motifs, are important due to their presence in a wide variety of biologically significant compounds. While the homo N-N coupling of two NH moieties to form the hydrazide N-N bond is well developed, the cross ...
Subban Kathiravan, Prakriti Dhillon, Tianshu Zhang, Ian A. Nicholls   +3 more
doaj   +1 more source

Ultrasonic and mechanochemical strategies for the synthesis of oxindole scaffolds mediated by hypervalent iodine(iii) reagents. [PDF]

RSC Adv
Sivaraj N, Singh FV.
europepmc   +1 more source

3d Transition Metals-Catalyzed Electrooxidative and Photoredox Asymmetric CH Activation: A Sustainable Futuristic Prospective. [PDF]

Chem Rec
Sarthi, Sharma T, Shrivastav A, Chandra D, Sharma U.   +4 more
europepmc   +1 more source

Divergent synthesis of indenoisoquinolines and indenoisochromenes by rhodium-catalysed cyclocondensation of <i>N</i>-substituted benzamides with 2-diazoindenediones. [PDF]

RSC Adv
Kim DY, Kimura Y, Miura R, Kondo T.
europepmc   +1 more source