Results 191 to 200 of about 6,457 (248)

The Synthesis of Benzazepines via Sequential [3 + 2]-Annulation and [3,3]-Sigmatropic Rearrangement.

Organic Letters
A novel annulation reaction of prop-2-ynylsulfonium salts with sulfur ylides and nitrosobenzenes has been developed, affording various benzazepines in moderate to good yields.
Fang Luo, Wei Wang, Chaowei Xiang, Ling-Hui Zeng, Chong Zhang, Jian-kang Zhang, Xingxian Zhang, Jiaan Shao, Huajian Zhu   +8 more
semanticscholar   +1 more source

Synthesis of 3-Benzazepines via Cobalt-Catalyzed C-H Bond Functionalization with CaC2 as the Acetylene Source.

Organic Letters
Herein, we report a simple method for the synthesis of 3-benzazepine derivatives via a cobalt-catalyzed, picolinamide-directed α-amidoacrylate C(sp2)-H bond functionalization approach.
Aleksandrs Cizikovs, Paula A. Zagorska, L. Grigorjeva   +2 more
semanticscholar   +1 more source

Phosphine-Catalyzed Divergent [4+3] Domino Annulations of CF3-Containing Imines with MBH Carbonates: Construction of Perfluoroalkylated Benzazepines.

Organic Letters, 2019
Phosphine-catalyzed divergent [4+3] domino annulations of fluorinated imidoyl chlorides with MBH carbonates were developed. Two classes of perfluoroalkylated benzazepines were obtained in moderate to good yields via an interesting dearomatization ...
Jun-Hua Chen, Zhongmo Yin, You Huang
semanticscholar   +1 more source

1-Benzazepines. The Synthesis and Reactivity of 2-Chloro-1,5-Dimethyl-1h-1-Benzazepines

Australian Journal of Chemistry, 1986
Treatment of laevulinic acid with N- methylaniline yields 1,5-dimethyl- 1H-1-benzazepin-2(3H)-one and 5-methyl-5-[4-( methylamino )phenyl]-1- phenylpyrrolidin-2-one. The structure of the latter is confirmed by a single-crystal X-ray study. The yield of benzazepinone is increased if either m- methoxy-N-methylaniline or m-methyl-N- methylaniline is ...
S. Mitkas, Allan H. White, Rolf H. Prager, Roger N. Hayes, M. B. Stringer, Brian W. Skelton, John H. Bowie, Mark J. Raftery   +7 more
openaire   +3 more sources

2-Benzazepines. 5. Synthesis of pyrimido[5,4-d][2]benzazepines and their evaluation as anxiolytic agents

Journal of Medicinal Chemistry, 1983
A series of 5H-pyrimido[5,4-d][2]benzazepines has been synthesized, starting from the corresponding 2-benzazepin-5-ones, and evaluated as potential anxiolytic agents. Selected compounds from this series show a pharmacological profile of action different than that of diazepam. They are more potent than diazepam in the anti-pentylenetetrazole test and in
J. Sepinwall, Earley Jv, Fryer Ri, Eugene John Trybulski, Reeder E, Armin Walser, W. D. Horst, Louis E. Benjamin, A. B. Davidson, Norman W. Gilman   +9 more
openaire   +3 more sources

Synthesis of Ring-Fused 1-Benzazepines via [1,5]-Hydride Shift/7-Endo Cyclization Sequences.

Organic Letters, 2017
Synthesis of 1-benzazepines has been achieved via a [1,5]-hydride shift/7-endo cyclization sequence. The focus of this research is a direct transformation of 2-(aryl)cyclopropane 1,1-diester derivatives into 1-benzazepines using a cyclopropane moiety as ...
Chang Won Suh, Su Jin Kwon, D. Kim
semanticscholar   +1 more source

ChemInform Abstract: 2‐Benzazepines. Part 9. Synthesis and Chemistry of 3H‐2‐Benzazepine and Pyrimido(4,5‐d)(2)benzazepine Derivatives.

ChemInform, 1987
AbstractThe benzazepines (II), prepared from the acetylenes (I), are transformed into the isomeric esters (VI) and (VII) by consecutive bromination, dehydrobromination, and palladium‐catalyzed alkoxycarbonylation.
L. Todaro, Eugene J. Trybulski, Rodney Ian Fryer, S. Vitone, Earl Reeder   +4 more
openaire   +2 more sources

Synthesis of Benzazepines Bearing Three Contiguous Carbon Stereocenters through Pd(II)-Catalyzed [3 + 2] Cycloaddition of N-Aryl Nitrones with Allenoates.

Journal of Organic Chemistry
A cascade reaction of Pd(II)/dppben-catalyzed [3 + 2] cycloaddition of N-aryl nitrones with allenoates and sequential reduction has been developed for the synthesis of functionalized benzazepines bearing three contiguous carbon stereocenters in moderate ...
Su-Ge Xin, Shan Chen, Jia-Hui Qin, Hong-yan Bi, Cui Liang, Chunhua Chen, Dong‐Liang Mo   +6 more
semanticscholar   +1 more source

Synthesis and Biological Evaluation of Benzazepine Oxazolidinone Antibacterials.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Betty H. Yagi, Judith C. Hamel, Paul D. Johnson, Ford Charles W, Douglas Stapert, Gary E. Zurenko, Ronda D. Schaadt, Judy K. Moerman, Paul Adrian Aristoff   +8 more
openaire   +4 more sources

Synthesis of Spiro[benzazepine-2,4‘-piperidine]

The Journal of Organic Chemistry, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
D. Gomez Pardo, J.-L. Peglion and, Aimee Dessinges, Janine Cossy, C. Poitevin† and   +4 more
openaire   +3 more sources