Results 51 to 60 of about 6,469 (247)

Enantioselective palladium(0)-catalyzed C-H arylation strategy for chiral heterocycles [PDF]

, 2017
Transition-metal-catalyzed C-H functionalizations have emerged as complementary and powerful tools to access molecular complexity from widely available starting materials.
Cramer, Nicolai, Saget, Tanguy
core  

A suitable preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines and their ring homologs with a reusable Preyssler heteropolyacid as catalyst [PDF]

, 2010
The preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines, N-sulfonyl-2,3,4,5-tetrahydro-1H-2-benzazepines and N-sulfonyl-1,2,3,4,5,6-hexahydrobenzazocine was catalyzed by a Preyssler heteropolyacid, H₁₄[NaP₅W₃₀O₁₁₀], (PA), supported on silica ...
Autino, Juan Carlos, Giaccio, Héctor E., Romanelli, Gustavo Pablo, Ruiz, Diego Manuel   +3 more
core   +1 more source

Recent Total Syntheses of Cephalotaxine‐Type Alkaloids and Their Structural Diversification (2021–2024): An Update

Asian Journal of Organic Chemistry, Volume 14, Issue 3, March 2025.
This review presents an analysis of ten recent total syntheses of cephalotaxine‐type alkaloids published between 2021 and 2024. The structural diversification strategies developed during this period are described. Additionally, a new structural classification system for this alkaloid class is proposed.
Yeju Oh, Anagha Reneesh, Hongjun Jeon
wiley   +1 more source

In vitro activity against Leishmania and human skin permeation of miltefosine ultradeformable liposomes [PDF]

, 2014
Introducción: los liposomas ultradeformables de miltefosina (LUD-MIL) constituyen una opción para el tratamiento tópico en leishmaniasis cutánea penetrando los estratos de la piel hasta la dermis, sitio donde habita el parásito.
Escobar Rivero, Patricia, Hernandez, Indiira Paola, Martinetti Montanari, Jorge Anibal   +2 more
core   +1 more source

Synthesis of Benzazepine Alkaloids and Related Compounds

HETEROCYCLES, 1975
Tetsuji Kametani, Keiichiro Fukumoto
openalex   +3 more sources

Designing organometallic compounds for catalysis and therapy [PDF]

, 2012
Bioorganometallic chemistry is a rapidly developing area of research. In recent years organometallic compounds have provided a rich platform for the design of effective catalysts, e.g. for olefin metathesis and transfer hydrogenation.
Abraha Habtemariam, Aird, Alama, Alama, Alberto, Allardyce, Allen, Allen, Ana M. Pizarro, Anand, Ang, Ang, Anna Louisa Noffke, Arancibia, Barragan, Barry, Barry, Barry, Barry, Bergamo, Bergamo, Betanzos-Lara, Betanzos-Lara, Betanzos-Lara, Brewster, Bugarcic, Bugarcic, Canivet, Carrión, Caruso, Casini, Casini, Casini, Chaplin, Chen, Chen, del Pozo, Desmard, Dorcier, Dorcier, Dougan, Dougan, Dyson, Erxleben, Feng, Fernandez, Filak, Fu, Fu, Fujii, Giannini, Gormen, Gossens, Grau, Grguric-Sipka, Grubbs, Gröger, Guichard, Guo, Guo, Habtemariam, Hambley, Hamels, Hanif, Hanif, Harris, Hartinger, Hashiguchi, Hayes, Hayward, Herman, Hindi, Hogan, Hollmann, Hu, Hull, Ito, Jafarpour, Jennerwein, Jira, Jungwirth, Kandioller, Kisova, Kljun, Kopf, Kopf-Maier, Kopf-Maier, Kopf-Maier, Kopf-Maier, Kröger, Kuninobu, Lee, Leiva, Li, Liu, Liu, Liu, Liu, Liu, Lo, Lo, Lummen, Lutz, Maenaka, Meggers, Meggers, Meggers, Melchart, Melchart, Melchart, Melendez, Mendes, Motterlini, Mross, Novakova, Novakova, Novakova, Noyori, Noyori, Oehninger, Ogo, Ogo, Olliaro, Page, Patiño, Peacock, Peacock, Peacock, Peacock, Pelletier, Peter J. Sadler, Petzold, Petzold, Pitto-Barry, Pitto-Barry, Pizarro, Plazuk, Rocamora-Reverte, Ruiz, Ruppert, Sandoval, Sanford, Sarsam, Schatzschneider, Schmid, Schäfer, Scolaro, Selander, Skinner, Sriskandakumar, Steckhan, Strohfeldt, Suss-Fink, Sweeney, Takebayashi, Tan, Therrien, Therrien, Toney, Top, Top, Top, Trnka, Turel, van der Donk, van Rijt, van Rijt, van Rijt, Vessières, Vougioukalakis, Vougioukalakis, Wang, Wang, Wang, Ward, Williams, Williams, Wong, Wu, Wu, Yabluchanskiy, Yamakawa, Yan, Yano, Yuasa, Zava, Zekri, Zhao, Zoeller   +188 more
core   +1 more source

A hydrazine-free Wolff–Kishner reaction suitable for an undergraduate laboratory [PDF]

, 2016
A Wolff–Kishner reaction that does not require hydrazine has been developed. The reaction sequence has two steps; formation of a carbomethoxyhydrazone from methyl hydrazinocarboxylate and acetophenone, then decomposition of this intermediate by treatment
Cranwell, Philippa B., Russell, Andrew T.   +1 more
core   +1 more source

Phenol (bio)isosteres in drug design and development

Archiv der Pharmazie, Volume 358, Issue 1, January 2025.
This review explores the pivotal role of phenol bioisosteres in drug design, highlighting their potential to overcome the limitations of phenolic compounds, such as poor bioavailability and rapid metabolism. By examining diverse bioisosteric replacements, from benzimidazolones to quinolinones, it is demonstrated how these modifications enhance drug ...
Calvin Dunker, Katja Schlegel, Anna Junker   +2 more
wiley   +1 more source

Optimized psilocybin production in tryptophan catabolism‐repressed fungi

Microbial Biotechnology, Volume 17, Issue 11, November 2024.
Here, we developed an in vivo psilocybin production chassis, based on repression of l‐tryptophan catabolism. By genome mining, we identified two aminotransferase ARO8/9 orthologs in Aspergillus nidulans involved in l‐tryptophan catabolism. Double deletion of the aminotransferase genes aroH1 and aroH2 resulted in a 10‐fold increased psilocybin ...
Slavica Janevska, Sophie Weiser, Ying Huang, Jun Lin, Sandra Hoefgen, Katarina Jojić, Amelia E. Barber, Tim Schäfer, Janis Fricke, Dirk Hoffmeister, Lars Regestein, Vito Valiante, Johann E. Kufs   +12 more
wiley   +1 more source

Neuroblastoma and its Target Therapies: A Medicinal Chemistry Review

ChemMedChem, Volume 19, Issue 9, May 2, 2024.
Searching for a cure for neuroblastoma: This review highlights the urgent need to find a cure for high‐risk neuroblastoma. It provides an overview of the current treatment available and the drug discovery approach of seven drugs that reached clinical trial.
A. Gerges, U. Canning
wiley   +1 more source