A hydrazine-free Wolff–Kishner reaction suitable for an undergraduate laboratory [PDF]
, 2016 A Wolff–Kishner reaction that does not require hydrazine has been developed. The reaction sequence has two steps; formation of a carbomethoxyhydrazone from methyl hydrazinocarboxylate and acetophenone, then decomposition of this intermediate by treatment
Cranwell, Philippa B. +1 more
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ChemBioChem, Volume 25, Issue 2, January 15, 2024.We herein report the identification of UR‐NR435 (25), a SCH‐23390‐based fluorescent ligand bearing a 5‐TAMRA dye, as suitable for fluorescence microscopy at the D1R. Single‐digit nanomolar binding affinity could be determined in radioligand competition binding and molecular brightness studies at D1‐like receptors.
Niklas Rosier +11 more
wiley +1 more source
Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides [PDF]
, 2008 A number of new analogs of 3,3-dimethyl-4,5-dihydro-3H-2-benzazepine 2-oxide, structurally related to the nitrone spin trap α-phenyl-N-tert-butylnitrone (PBN), were synthesized and evaluated for their activity in vitro as protectants against oxidative ...
Altomare, Cosimo +7 more
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Enantioselective palladium(0)-catalyzed C-H arylation strategy for chiral heterocycles [PDF]
, 2017 Transition-metal-catalyzed C-H functionalizations have emerged as complementary and powerful tools to access molecular complexity from widely available starting materials.
Cramer, Nicolai, Saget, Tanguy
core
Reactions of [2-(Bromomethyl)phenyl](4-chlorophenyl)methanone: A New Synthesis of [1,3]Thiazolo[3,2-b][2,4]benzodiazepine, Benzimidazo[1,2-b][2,4]benzodiazepine and Benzimidazo[1,2-b][2]benzazepine Derivatives [PDF]
, 2019 A new approach to the development of a number of azolo-condensed azepines and diazepines has been proposed. The method for the synthesis of [1,3]thiazolo[3,2-b][2,4]benzodiazepine, benzimidazo[1,2-b][2,4]benzodiazepineandbenzimidazo[1,2-b][2 ...
Davydov, Valentyn +2 more
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In vitro activity against Leishmania and human skin permeation of miltefosine ultradeformable liposomes [PDF]
, 2014 Introducción: los liposomas ultradeformables de miltefosina (LUD-MIL) constituyen una opción para el tratamiento tópico en leishmaniasis cutánea penetrando los estratos de la piel hasta la dermis, sitio donde habita el parásito.
Escobar Rivero, Patricia +2 more
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Preparation of substituted tetrahydro-1-benzazepines by lithiation-trapping [PDF]
, 2018 The tetrahydro‐1‐benzazepine or benzo[b]azepine ring system is found in a number of drug molecules although methods to access 2,2‐disubstituted derivatives are rare. Here we report the preparation of N‐tert‐butoxycarbonyl‐2‐phenyltetrahydro‐1‐benzazepine
Aeyad +38 more
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Arylbenzazepines Are Potent Modulators for the Delayed Rectifier K+ Channel: A Potential Mechanism for Their Neuroprotective Effects [PDF]
, 2010 (±) SKF83959, like many other arylbenzazepines, elicits powerful neuroprotection in vitro and in vivo. The neuroprotective action of the compound was found to partially depend on its D1-like dopamine receptor agonistic activity. The precise mechanism for
Bernhard, Eric J. +7 more
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Azabicyclo chemistry II. Synthesis of 1,5‐methano‐2,3,4,5‐tetrahydro‐1H‐2‐benzazepines. B‐norbenzomorphans [PDF]
, 1970 Michael Mokotoff, Arthur E. Jacobson
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Synthesis of Sultams from Vinyl Aziridines and 1,4-Diazabicyclo[2.2.2]octane bis(sulfur dioxide) [PDF]
, 2020 Sultams are an important functional group found in medicinal compounds with anticancer and enzyme inhibition activity. Traditional methods for sultam synthesis often require harsh conditions and have limited substrate scope.
Gandara, John
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