Results 101 to 110 of about 8,103 (214)

Synthesis of Benzopyrans and Quinolines with Nitrogenated Chain and Their Cytotoxicity Against Human Cancer Cell Lines

ChemMedChem, Volume 21, Issue 2, January 2026.
Natural products and/or their structural analogs represent the greatest number of approved small‐molecules as antitumor agents. We report the synthesis of 2‐propanamide and 2‐propanamine dihydrobenzopyrans and 2‐ and 2,3‐disubstituted quinolines to evaluate their cytotoxicity against human A549 (lung), A2058 (melanoma), HepG2 (liver), MCF‐7 (breast ...
Bernabeu‐Sanchis Álvaro, Thomas A. Mackenzie, Maria C. Ramos, Ainhoa García, Carlos Villarroel‐Vicente, Laura Vila, José R. Tormo, Diego Cortes, Nuria Cabedo   +8 more
wiley   +1 more source

Toxic Tear Gas 2‐Chloroacetophenone (CN) Forms Adducts With Endogenous Plasma Thiols In Vitro Valuable as Biomarkers of Exposure

Drug Testing and Analysis, Volume 18, Issue 1, Page 74-84, January 2026.
Incubation of human plasma with the tear gas 2‐chloroacetophenone (CN) led to the formation of acetophenone (AcPhen)‐adducts with the small plasma thiols glutathione, homocysteine, and cysteine persulfide. The AcPhen‐adducts were either bound to an organic thiol‐group or to an organic persulfide. The adducts were detected with a mass spectrometry‐based
Paula Helena Sieber, Dirk Steinritz, Franz Worek, Harald John   +3 more
wiley   +1 more source

A Direct and an Efficient Regioselective Synthesis of 1,2-Benzothiazine 1,1-dioxides, β-Carbolinones, Indolo[2,3-c]pyran-1-ones, Indolo[3,2-c]pyran-1-ones, Thieno[2,3-c]pyran-7-ones and Pyrano[3’,4’:4,5]imidazo[1,2-a]pyridin-1-ones via Tandem Stille/Heterocyclization Reaction

Molecules, 2020
A general regioselective one-pot synthesis of 1,2-benzothiazine 1,1-dioxides from 2-iodo benzenesulfonamide moieties and allenylstannanes is described using a domino Stille-like/Azacyclization reaction. The conditions developed also opened a novel access
Badr Jismy, Khalil Cherry, Carine Maaliki, Samuel Inack Ngi, Mohamed Abarbri   +4 more
doaj   +1 more source

4-Chloro-N-(3-methylbenzoyl)benzenesulfonamide monohydrate

, 2011
In the title compound, C14H12ClNO3S·H2O, the dihedral angle between the sulfonyl and benzoyl benzene rings is 84.4 (2)°. In the crystal, every water molecule forms four hydrogen bonds with three different molecules of 4-chloro-
P. A. Suchetan, Sabine Foro, M. Shet Prakash, B. Thimme Gowda   +3 more
core   +1 more source

Carbonic Anhydrase 12 as a Novel Prognostic Biomarker and Therapeutic Target for High‐Risk Follicular Thyroid Carcinoma

Cancer Science, Volume 117, Issue 1, Page 257-271, January 2026.
In this study, we identified a novel biomarker, carbonic anhydrase 12 (CA12), to better distinguish high‐risk follicular thyroid carcinoma (FTC). High CA12 expression is associated with poor prognosis and CA12 promotes tumor cell growth and invasion. This study suggests that CA12 is not only an independent predictor of disease‐free survival but also a ...
Masashi Tanida, Tsuyoshi Takashima, Shinichiro Tahara, Masaharu Kohara, Haruka Kanai, Masami Suzuki, Motoyuki Suzuki, Mitsuyoshi Hirokawa, Ayana Suzuki, Shinya Sato, Daisuke Okuzaki, Satoshi Nojima, Takahiro Matsui, Hidenori Inohara, Eiichi Morii   +14 more
wiley   +1 more source

Crystal structures of isomeric 3,5-dichloro-N-(2,3-dimethylphenyl)benzenesulfonamide, 3,5-dichloro-N-(2,6-dimethylphenyl)benzenesulfonamide and 3,5-dichloro-N-(3,5-dimethylphenyl)benzenesulfonamide

Acta Crystallographica Section E: Crystallographic Communications, 2017
The crystal structures of three isomeric compounds of formula C14H13Cl2NO2S, namely 3,5-dichloro-N-(2,3-dimethylphenyl)-benzenesulfonamide (I), 3,5-dichloro-N-(2,6-dimethylphenyl)benzenesulfonamide (II) and 3,5-dichloro-N-(3,5-dimethylphenyl ...
K. Shakuntala, S. Naveen, N. K. Lokanath, P. A. Suchetan   +3 more
doaj   +1 more source

2-Chloro-N-(4-chlorobenzoyl)benzenesulfonamide toluene hemisolvate

, 2010
The unit cell of the title compound, C13H9Cl2NO3S·0.5C7H8, contains two molecules of 2-chloro-N-(4-chlorobenzoyl)benzenesulfonamide and one toluene molecule, which is disordered about a centre of inversion.
P. A. Suchetan, Sabine Foro, B. Thimme Gowda   +2 more
core   +1 more source

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib:  A Potent and Selective Inhibitor of COX-2

, 2016
4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib:  A Potent and Selective Inhibitor of COX-
Alexander F. Shaffer (3024486), John J. Talley (1515478), Roland S. Rogers (3024489), Matthew J. Graneto (2467696), Ben S. Zweifel (3018042), William E. Perkins (3010233), Karen Seibert (3010203), Jeffery S. Carter (3010215), Jaime L. Masferrer (3010248), David L. Brown (2309755), Yan Y. Zhang (3010206), Carol M. Koboldt (3010212)   +11 more
core   +1 more source

In Silico Assessment of Enaminone–Sulfanilamides as Potential Carbonic Anhydrase II Inhibitors: Molecular Docking and ADMET Prediction

Chemistry Proceedings
Carbonic anhydrases (CAs) are a group of zinc-containing enzymes involved in many physiological processes through their role in the maintenance of the equilibrium between bicarbonate and CO2 levels.
Yousra Ouafa Bouone, Abdeslem Bouzina, Rachida Mansouri, Nour-Eddine Aouf   +3 more
doaj   +1 more source

Nitrogen-15 Nuclear Magnetic Resonance Study of Benzenesulfonamide and Cyanate Binding to Carbonic Anhydrase

, 1983
The binding of inhibitors, cyanate and benzenesulfonamide, to the active-site zinc of human carbonic anhydrase B was studied by ^(15)N nuclear magnetic resonance spectroscopy.
Roberts, John D., Kanamori, Keiko
core