Results 61 to 70 of about 8,103 (214)

CSAKD: Determining Absolute Ligand Affinities From 19F NMR Chemical Shift Anisotropy

Angewandte Chemie International Edition, EarlyView.
Affinity determination is crucial in drug discovery, yet remains difficult for weakly binding fragments. We introduce chemical shift anisotropy KD$K_{\text{D}}$ (CSAKD) by 19F$^{19}{\rm F}$ NMR relaxation experiments, a titration‐free method that requires no isotopic labeling.
Simon H. Rüdisser, Gabriela Stadler, Alvar D. Gossert   +2 more
wiley   +1 more source

4-Methoxy-N-(1-methyl-1H-indazol-7-yl)benzenesulfonamide hemihydrate

IUCrData, 2017
The asymmetric unit of the title compound, 2C15H15N3O3S·H2O, comprises two crystallographically independent organic molecules and one water molecule, all in general positions.
Latifa Bouissane, Souad Mojahidi, El Mostapha Rakib, Hakima Chicha, Mohamed Saadi, Lahcen El Ammari   +5 more
doaj   +1 more source

Novel Leu-Val Based Dipeptide as Antimicrobial and Antimalarial Agents: Synthesis and Molecular Docking

Frontiers in Chemistry, 2020
The increase of antimicrobial resistance (AMR) and antimalarial resistance are complex and severe health issues today, as many microbial strains have become resistant to market drugs.
James A. Ezugwu, James A. Ezugwu, Uchechukwu C. Okoro, Mercy A. Ezeokonkwo, China R. Bhimapaka, Sunday N. Okafor, David I. Ugwu, Ogechi C. Ekoh, Solomon I. Attah   +8 more
doaj   +1 more source

Pyridazinone substituted benzenesulfonamides as potent carbonic anhydrase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2016
A series of sulfonamide derivatives (2a-l) incorporating substituted pyridazinone moieties were investigated for the inhibition of two human cytosolic carbonic anhydrase isoforms, hCA I and hCA II. All these compounds, together with the clinically used sulfonamide acetazolamide were investigated as inhibitors of the physiologically relevant isozymes I ...
Yaseen, Raed, Ekinci, Deniz, Senturk, Murat, Hameed, Alhamzah D.h., Ovais, Syed, Rathore, Pooja, Samim, Mohammed, Javed, Kalim, SUPURAN, CLAUDIU TRANDAFIR   +8 more
openaire   +6 more sources

4-Bromo-N-(4-bromophenyl)benzenesulfonamide [PDF]

IUCrData, 2016
The molecule of the title compound, C12H9Br2NO2S, is U shaped with the central C—S—N—C segment having a torsion angle of 63.2 (4)°. Further, the dihedral angle between the benzene rings is 38.5 (2)°. The crystal structure features strong N—H...O hydrogen bonds that form infinite [100]C(4) chains.
Vinola Z. Rodrigues, S. Naveen, N. K. Lokanath, P. A. Suchetan   +3 more
openaire   +2 more sources

Thermoresponsive cyclodextrins with benzenesulfonamide showing tunable inhibition for carbonic anhydrase

, 2017
A thermally induced collapse provides a switchable microenvironment to reversibly regulate enzyme activity through introducing benzenesulfonamide ligands into thermoresponsive oligoethylene glycol-modified cyclodextrins.
Huang Shi, Kun Liu, Afang Zhang, Runlang Zhu, Jiatao Yan, Apan Qian, Wen Li   +6 more
core   +1 more source

Recent Advances in Photocatalyst‐Driven Protein Labeling and Proximity Mapping

The Chemical Record, EarlyView.
Photocatalyst‐driven protein labeling and proximity mapping have rapidly advanced as powerful strategies for spatiotemporal control in complex biological environments. This review integrates recent developments across single‐electron transfer and energy transfer‐based mechanisms and highlights how catalyst design, reactive intermediates, and diffusion ...
Shinichi Sato, Kazuki Miura, Juki Nakao, Hiroyuki Nakamura   +3 more
wiley   +1 more source

Pioglitazone Synthetic Analogue Ameliorates Streptozotocin-Induced Diabetes Mellitus through Modulation of ACE 2/Angiotensin 1–7 via PI3K/AKT/mTOR Signaling Pathway

Pharmaceuticals, 2022
The renin angiotensin aldosterone system has a localized key regulatory action, especially in liver and body circulation. Furthermore, it accomplishes a significant role in the downregulation of the PI3K/AKT/mTOR signaling pathway that is involved in ...
Yasmin M. Ahmed, Mohamed A. Abdelgawad, Khaled Shalaby, Mohammed M. Ghoneim, Asmaa M. AboulMagd, Nada S. Abdelwahab, Hossam M. Hassan, Asmaa M. Othman   +7 more
doaj   +1 more source

4-{[4-(Dimethylamino)benzylidene]amino}benzenesulfonamide [PDF]

, 2014
The title Schiff base compound, C15H17N3O2S, is non-planar with a dihedral angle of 69.88 (4)° between the planes of the benzene rings. In the crystal, pairs of N—H...N hydrogen bonds, between the sulfonamide nitrogen-H atom and the azomethine N atom ...
Türkmen, Hasan, Hökelek, Tuncer, Tuncay Tunç, Durgun, Mustafa, Tunç, H., Tunç, Tuncay, Mustafa Durgun, Hasan Türkmen, Tuncer Hökelek   +8 more
core   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source