Results 51 to 60 of about 8,103 (214)

Benzo[g]quinazolin-based scaffold derivatives as dual EGFR/HER2 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Targeting EGFR has proven to be beneficial in the treatment of several types of solid tumours. So, a series of novel 2-(4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydrobenzo[g]quinazolin-2-ylthio)-N-substituted acetamide 5–19 were synthesised from the starting ...
Mostafa M. Ghorab, Mansour S. Alsaid, Aiten M. Soliman, Abdullah A. Al-Mishari   +3 more
doaj   +1 more source

Synthesis and COX-2 Inhibitory Activity of 4-[(E)-2-(4-Oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethenyl]benzene-1-sulfonamide and Its Analogs

Pharmaceuticals, 2012
Some novel 3-phenyl-2-[(E)-2-phenylethenyl]-3,4-dihydroquinazolin-4-one derivatives possessing para-sulfonamides groups on the phenyl ring of the 2-phenylethenyl moiety have been synthesized and their COX-2 inhibitory activity evaluated. The stuctures of
Hayun, Sumi Hudiyono, Muhammad Hanafi, Arry Yanuar   +3 more
doaj   +1 more source

Synthesis, Molecular Docking Analysis, ADMET and Drug Likeness Prediction of a Benzenesulfonamide Derivative Analogue of SLC-0111

Medical Sciences Forum, 2022
Carbonic anhydrases are metalloenzymes that regulate the interconversion of CO2 and H2CO3, a reaction involved in many physiological processes. A disfunction of these enzymes is known to induce many diseases such as glaucoma, epilepsy and cancer.
Yousra Ouafa Bouone, Abdeslem Bouzina, Nour-Eddine Aouf   +2 more
doaj   +1 more source

Structure of FH535 (2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide) and FH535-N (2,5-dichloro-N-(4-nitronaphthalen-1-yl)benzenesulfonamide).

, 2019
Structure of FH535 (2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide) and FH535-N (2,5-dichloro-N-(4-nitronaphthalen-1-yl)benzenesulfonamide).
Eduardo Chacon (6392732), Chunming Liu (72065), Virgilius Cornea (6392738), Brett Spear (6392741), David S. Watt (1316937), Catherine Garcia (5316101), Roberto Gedaly (579900), Pedro Eman (6392735), Lilia Turcios (6392729), Jieyun Jiang (429341), Francesc Marti (1846048)   +10 more
core   +1 more source

N-(2,6-Dimethylphenyl)benzenesulfonamide

, 2008
In the crystal structure of the title compound, C14H15NO2S, the N—H bond is trans to one of the S=O double bonds, similar to what is observed in N-(2-methylphenyl)benzenesulfonamide and other aryl sulfonamides.
K. S. Babitha, Hartmut Fuess, Sabine Foro, B. Thimme Gowda   +3 more
core   +1 more source

N-(3-Chlorophenyl)benzenesulfonamide

, 2008
In the crystal structure of the title compound, C12H10ClNO2S, the N—H bond is trans to one of the S=O bonds. The two aromatic rings form a dihedral angle of 65.4 (1)°, compared with a value of 49.1 (1)° in N-(2-chlorophenyl ...
K. S. Babitha, Hartmut Fuess, Sabine Foro, B. Thimme Gowda   +3 more
core   +1 more source

2,5-Dichloro-N-(3-methylphenyl)benzenesulfonamide

Acta Crystallographica Section E Structure Reports Online, 2012
In the title compound, C13H11Cl2NO2S, the dihedral angle between the aromatic rings is 76.62 (10)° and the C—S—N—C linkage between the rings adopts agaucheconformation [torsion angle = −51.4 (2)°]. A weak intramolecular C—H...O interaction closes anS(6) ring.
Shumaila Younas Mughal, Islam Ullah Khan, William T. A. Harrison, Muneeb Hayat Khan, Muhammad Nadeem Arshad   +4 more
openaire   +3 more sources

4-methyl-N-[2-(tosylamino)phenyl]benzenesulfonamide

, 2022
This dataset contains experimental data from a sample (4-methyl-N-[2-[(4-methylphenyl)sulfonylamino]phenyl]benzenesulfonamide, InChI=1S/C20H20N2O4S2/c1-15-7-11-17(12-8-15)27(23,24)21-19-5-3-4-6-20(19)22-28(25,26)18-13-9-16(2)10-14-18/h3-14,21-22H,1-2H3).
Klein, Jérôme
core   +1 more source

4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases

Molecules, 2014
A series of N-aryl-β-alanine derivatives and diazobenzenesulfonamides containing aliphatic rings were designed, synthesized, and their binding to carbonic anhydrases (CA) I, II, VI, VII, XII, and XIII was studied by the fluorescent thermal shift assay ...
Kęstutis Rutkauskas, Asta Zubrienė, Ingrida Tumosienė, Kristina Kantminienė, Marytė Kažemėkaitė, Alexey Smirnov, Justina Kazokaitė, Vaida Morkūnaitė, Edita Čapkauskaitė, Elena Manakova, Saulius Gražulis, Zigmuntas J. Beresnevičius, Daumantas Matulis   +12 more
doaj   +1 more source

N-(4-Hydroxyphenyl)benzenesulfonamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
The title compound, C(12)H(11)NO(3)S, synthesized by the reaction of benzene sulfonyl chloride with para-amino-phenol, is of inter-est as a precursor to biologically active sulfur-containing heterocyclic compounds. The structure is stabilized by N-H⋯O and O-H⋯O hydrogen bonds.
Islam Ullah Khan, Irfana Mariam, Muhammad Zia‐ur‐Rehman, M. Arif Sajjad, Shahzad Sharif   +4 more
openaire   +2 more sources