Results 111 to 120 of about 33,790 (273)

Synthesis and biological characterization of 4,4‐difluoro‐3(phenoxymethyl)piperidine scaffold as dopamine 4 receptor (D4R) antagonist in vitro tool compounds

open access: yesChemMedChem, Accepted Article.
We report the discovery and characterization of a novel series of 4,4‐difluoropiperidine etherbased dopamine D4 receptor antagonists. Structure‐activity relationship studies led to the identification of compound 14a, which displays exceptional binding affinity for the D4 receptor (Ki = 0.3 nM) and remarkable selectivity over other dopamine receptor ...
Saeedeh Saeedi   +3 more
wiley   +1 more source

Impact of chelation on reactivity and cytotoxicity of hemilabile biphenyl gold(III) N‐heterocyclic carbene complexes

open access: yesChemMedChem, Accepted Article.
Although great progresses have been accomplished in the field of antineoplastic treatments, the need for chemotherapy agents with new mechanisms of action remains essential. Metal complexes presenting hemilabile ligands could combine structural toxicity upon full coordination of the ligand and reactive toxicity upon ligand partial decoordination ...
Tom Lacoma   +6 more
wiley   +1 more source

Compression‐Induced Amorphization of ZIF‐62 Leading to Formation of Porous Glass: Overcoming the Limitations of Current Methods

open access: yesChemistry–Methods, EarlyView.
Nonhydrostatic compression in steps is applied to transform crystalline zeolitic imidazolate framework‐62 into glass at room temperature. This method overcomes the limitations of existing approaches. This research reveals the mechanism of this phase transformation, including modifications in porosity, using various techniques, particularly positron ...
Jaideep Mor   +4 more
wiley   +1 more source

Relationship between intraocular pressure lowering effect and chemical structure of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole derivatives

open access: yesData in Brief, 2018
This article contains data that relate to the study carried out in the work of Marcus et al. (2018) [1]. Data represent an information about pharmacophore analysis of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole derivatives and results of
Pavel Vassiliev   +6 more
doaj  

QTAIM Analysis of a [2]Rotaxane Molecular Shuttle with a 2,2′‐Bipyridyl Rigid Core

open access: yesChemPhysChem, EarlyView.
Supramolecular assembly of a rigid H‐shaped [2]rotaxane composed of 24C8 macrocycle on a molecular thread containing two benzimidazole recognition sites and a central 2,2’‐bipyridyl core is investigated by combining QTAIM with DFT algorithms. The derived interaction patterns shed some light on the mutual position of the 24C8 ring along the axle ...
Costantino Zazza   +3 more
wiley   +1 more source

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