Results 1 to 10 of about 9,350 (208)

Review- biological active benzimidazole derivatives

Results in Chemistry, 2021
In the field of Medicinal Chemistry, the uses of heterocyclic compounds increased day by day, because in many biological materials, heterocyclic compound is a part of its structure.
Balasaheb Pathare, Tanaji Bansode
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A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives [PDF]

Frontiers in Pharmacology, 2021
Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole scaffolds are considerably prevalent.
Shejuti Rahman Brishty, Md. Jamal Hossain, Mayeen Uddin Khandaker, Mohammad Rashed Iqbal Faruque, Hamid Osman, S. M. Abdur Rahman   +5 more
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Serious adverse events reported with benzimidazole derivatives: A disproportionality analysis from the World Health Organization's pharmacovigilance database. [PDF]

PLoS Neglected Tropical Diseases
BackgroundBenzimidazole derivatives are widely used anthelmintic drugs, particularly in mass campaigns for intestinal parasitosis treatment. Despite their generally good safety profile, serious adverse reactions have been reported.
Pamella Modingam, Jean-Luc Faillie, Jérémy T Campillo   +2 more
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Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine

Acta Pharmaceutica Sinica B, 2023
Cancer is the second leading cause of mortality globally which remains a continuing threat to human health today. Drug insensitivity and resistance are critical hurdles in cancer treatment; therefore, the development of new entities targeting malignant ...
Yeuan Ting Lee, Yi Jer Tan, Chern Ein Oon   +2 more
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Study, Protein Kinase Inhibition and Molecular Docking Study of Benzimidazole Derivatives [PDF]

Bioinformatics and Biology Insights
Kinase enzymes play an important role in cellular proliferation, and inhibition of their activity is a major goal of cancer therapy. Protein kinase inhibitors as benzimidazole derivatives can be applied for prevention or treatment of cancers through ...
Kamaraj Karthick, Kamaraj Abishek, Ebenezer Angel Jemima   +2 more
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Structure-based design of functionalized 2-substituted and 1,2-disubstituted benzimidazole derivatives and their in vitro antibacterial efficacy

Journal of Advanced Research, 2017
The aim of this present study was to synthesize 2-substituted and 1,2-disubstituted benzimidazole derivatives to investigate their antibacterial diversity for possible future drug design.
Olayinka O. Ajani, Olayinka O. Tolu-Bolaji, Shade J. Olorunshola, Yuxia Zhao, Damilola V. Aderohunmu   +4 more
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Design, synthesis of novel azo derivatives of benzimidazole as potent antibacterial and anti tubercular agents

Beni-Suef University Journal of Basic and Applied Sciences, 2018
A series of some novel azo derivatives of benzimidazole were prepared by coupling diazonium derivative of benzimidazole with various appropriate aromatic compounds.
Sujit Kumar Mohanty, Anuradha Khuntia, N. Yellasubbaiah, C. Ayyanna, B. Naga Sudha, M. Sai Harika   +5 more
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Antibacterial Activity of the Halogen- and Nitro Derivatives of Benzimidazole Against Bacillus Subtilis

Антибиотики и Химиотерапия, 2023
Background. Antibiotic resistance of bacteria is a serious concern for modern medicine. The search for new compounds with a pronounced antibacterial effect is an urgent task of pharmaceutical chemistry.
R. S. Begunov, D. O. Egorov, A. V. Chetvertakova, L. I. Savina, A. A. Zubishina   +4 more
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In-silico ADME prediction and molecular docking study of novel benzimidazole-1,3,4-oxadiazole derivatives as CYP51 inhibitors for antimicrobial activity

Journal of Applied Pharmaceutical Research, 2022
A class of innovative benzimidazole-1,3,4-Oxadiazole derivatives is a significant heterocyclic molecule for therapeutic development. In heterocyclic chemistry, the novel 1,3,4-Oxadiazole nucleus has a wide range of uses, including antibacterial ...
Shivanand Kolageri, S Hemanth, Mahesh Parit   +2 more
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An insight into the medicinal perspectives of mannich bases of benzimidazole derivatives: A review

International Journal of Research in Pharmaceutical Sciences, 2021
The heterocyclic aromatic compound benzimidazole is made up of benzene and an imidazole ring. In medicinal chemistry, it's a crucial pharmacophore and a privileged structure. It's a component of the vitamin cobalamin.
Vasuki B, Mahadevan N, Vijayabaskaran M, Mohanapriya K, Kosilamani P, Balaji K, Tamilselvan P, Sambathkumar R   +7 more
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