Results 41 to 50 of about 9,350 (208)

A review on biologically important benzimidazole derivatives

Results in Chemistry
Chemists have long been interested in the synthesis of benzimidazole derivatives, resulting in numerous studies on this heterocyclic compound. Its exceptional therapeutic efficacy in treating diseases has attracted further attention.
Vijayabharathi Sundharaj, V. Vijayakumar, S. Sarveswari   +2 more
doaj   +1 more source

Facile Synthesis, Characterization and in vitro Antibacterial Efficacy of Functionalized 2-Substituted Benzimidazole Motifs

Indonesian Journal of Chemistry, 2019
A series of functionalized 2-substituted benzimidazole motifs was designed and successfully synthesized via thermal cyclization of 1,2-diaminobenzene on COOH end of L- leucine to achieve benzimidazole derivatives 6 as the essential precursor.
Olayinka Oyewale Ajani, Olaoluwasubomi Eneyeme Joseph, King Tamunodikibugerere Iyaye, Natasha October, Damilola Victoria Aderohunmu, Shade John Olorunshola, Oluwatosin Yemisi Audu   +6 more
doaj   +1 more source

New Plant Growth Regulators of Benzimidazole Series

Chemistry Proceedings
Benzimidazole derivatives have a wide range of biological activity, including growth-regulating activity in relation to plants. The study of the structure-activity relationship (SAR) in a number of benzimidazole derivatives is important for the ...
Alena V. Yegorova, Anna E. Sklyar, Alevtina Yu. Yegorova, Vyacheslav S. Grinev   +3 more
doaj   +1 more source

Synthesis and Analgesic Activity of Novel Derivatives of 1,2-Substituted Benzimidazoles

Journal of Chemistry, 2013
A series of novel 2-phenylhydrazinomethyl and 2-(2-hydroxyphenyl)-benzimidazole derivatives substituted at the N1-position of benzimidazole nucleus were synthesized as well as screened for analgesic activity.
Shobhit Srivastava, S. N. Pandeya, Meena K. Yadav, B. K. Singh   +3 more
doaj   +1 more source

Synthesis, biological investigation, and docking studies of benzimidazole derivatives as butyrylcholinesterase and acetylcholinesterase inhibitors [PDF]

شیمی کاربردی روز
The cholinergic hypothesis is one of the hypotheses of Alzheimer's disease that shows the relationship between the onset and progression of the disease. One of the main ways to increase the level of acetylcholine is to inhibit cholinesterase enzymes. The
Maryam Rouhi, Sakineh Asghari, Zahra Ghanbari Masir   +2 more
doaj   +1 more source

Design and Synthesis of Benzimidazole-Chalcone Derivatives as Potential Anticancer Agents

Molecules, 2019
Numerous reports have shown that conjugated benzimidazole derivatives possess various kinds of biological activities, including anticancer properties.
Cheng-Ying Hsieh, Pi-Wen Ko, Yu-Jui Chang, Mohit Kapoor, Yu-Chuan Liang, Hsueh-Liang Chu, Hui-Hsien Lin, Jia-Cherng Horng, Ming-Hua Hsu   +8 more
doaj   +1 more source

Design, synthesis, and evaluation of anxiolytic activity of 2-(4-phenylpiperazin-1-yl)-1H-benz[d]imidazole and 2-(4-phenylpiperazin-1-methyl)-1H-benz[d]imidazole derivatives

Future Journal of Pharmaceutical Sciences
Background In contemporary society, anxiety has become a widespread disorder leading to compromised well-being and heightened depressive states. Extensive literature reviews indicate the diverse biological effects of benzimidazole and piperazine ...
Bhavna Sunil Mahajan, Laxman A. Kawale, Vandana S. Nade, Supriya Unavane, Lida Sajimon, Prajakta Kapadnis   +5 more
doaj   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

Animal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen, Xiangfang Tang, Yimin Zhuang, Shengjun Zhao, Ying Ren, Xiaokang Lv   +5 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Accelerating green heterocyclic synthesis: Convergence of AI, automation, and sustainable chemistry

Bulletin of the Korean Chemical Society, EarlyView.
Green heterocyclic synthesis and data‐driven tools such as AI, high‐throughput experimentation, continuous flow, and self‐driving laboratories have developed largely in parallel. This review connects them and asks how green metrics such as E‐factor and PMI might serve as explicit optimization targets rather than post‐hoc measures, toward sustainable ...
Noor Aisyah Ahmad Shah, Amirreza Mottafegh, Su‐Hyun Yoo, Jongwoon Kim, Minseon Byeon, Juhwan Noh, Yea‐Lee Lee, Jin Suk Myung, Gwang‐Noh Ahn   +8 more
wiley   +1 more source