Results 11 to 20 of about 636,119 (261)

Benzimidazole and its derivatives: Recent Advances (2020–2022)

Results in Chemistry, 2023
Benzimidazoles are fused heterocyclic ring systems containing two nitrogen atoms. They have vital therapeutic significance in drug discovery. Many clinically approved drugs have been developed from benzimidazole, and these include liarozole and ...
Oluwakemi Ebenezer, Micheal Shapi, Funsho Oyetunde-Joshua, Oluwadamilare D. Omotoso   +3 more
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Relationship between intraocular pressure lowering effect and chemical structure of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole derivatives

Data in Brief, 2018
This article contains data that relate to the study carried out in the work of Marcus et al. (2018) [1]. Data represent an information about pharmacophore analysis of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole derivatives and results of
Alexander Spasov, Vera Anisimova, Renu Agarwal, Adrian Julian Marcus, Igor Iezhitsa, Pavel Vassiliev, Olga Zhukovskaya   +6 more
core   +2 more sources

Cyclic Benzimidazole Derivatives and Their Antitumor Activity [PDF]

Kemija u Industriji, 2008
U posljednjih nekoliko godina interes za proučavanem kemije benzimidazola znatno je porastao zbog njihovog širokog spektra biološkog djelovanja, kao i mnogobrojnih mogućnosti primjene kao materijala u elektronici, u elektrokemiji za zaštitu od korozije ...
Karminski-Zamola, G., G. Karminski-Zamola, Hranjec, M., M. Hranjec   +3 more
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A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives. [PDF]

Front Pharmacol, 2021
Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole scaffolds are considerably prevalent.
Brishty SR, Hossain MJ, Khandaker MU, Faruque MRI, Osman H, Rahman SMA.   +5 more
europepmc   +2 more sources

Serious adverse events reported with benzimidazole derivatives: A disproportionality analysis from the World Health Organization's pharmacovigilance database. [PDF]

PLoS Negl Trop Dis
BackgroundBenzimidazole derivatives are widely used anthelmintic drugs, particularly in mass campaigns for intestinal parasitosis treatment. Despite their generally good safety profile, serious adverse reactions have been reported.
Modingam P, Faillie JL, Campillo JT.
europepmc   +2 more sources

Antibacterial Activity of the Halogen- and Nitro Derivatives of Benzimidazole Against Bacillus Subtilis

Антибиотики и Химиотерапия, 2023
Background. Antibiotic resistance of bacteria is a serious concern for modern medicine. The search for new compounds with a pronounced antibacterial effect is an urgent task of pharmaceutical chemistry.
R. S. Begunov, D. O. Egorov, A. V. Chetvertakova, L. I. Savina, A. A. Zubishina   +4 more
doaj   +1 more source

In-silico ADME prediction and molecular docking study of novel benzimidazole-1,3,4-oxadiazole derivatives as CYP51 inhibitors for antimicrobial activity

Journal of Applied Pharmaceutical Research, 2022
A class of innovative benzimidazole-1,3,4-Oxadiazole derivatives is a significant heterocyclic molecule for therapeutic development. In heterocyclic chemistry, the novel 1,3,4-Oxadiazole nucleus has a wide range of uses, including antibacterial ...
Shivanand Kolageri, S Hemanth, Mahesh Parit   +2 more
doaj   +1 more source

Synthesis of benzimidazole-cyclohexanone derivatives [PDF]

, 2018
This work reports the synthesis and characterization of new benzimidazole-cyclohexanone derivatives 3a-d, 4a-d and 5a-d under different reaction conditions.
Amari, M., Belkacem, Z., Mechrouh, F., Derdour, M., Hoffmann, P., Belkheiri, N., Bachar, R.M., Fodili, M.   +7 more
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In Silico Study, Protein Kinase Inhibition and Molecular Docking Study of Benzimidazole Derivatives. [PDF]

Bioinform Biol Insights
Kinase enzymes play an important role in cellular proliferation, and inhibition of their activity is a major goal of cancer therapy. Protein kinase inhibitors as benzimidazole derivatives can be applied for prevention or treatment of cancers through ...
Karthick K, Abishek K, Angel Jemima E.
europepmc   +2 more sources

An updated review on benzimidazole derivatives as potential antihypertensive agents [PDF]

, 2022
A growing number of researchers in the field of medicinal chemistry are focused on nitrogenous heterocyclic compounds. Benzimidazole scaffolds appear often in this group of heterocyclic compounds.
Tajane, Pravin S., Sawant, Ramesh L.
core   +1 more source