Results 101 to 110 of about 74,387 (304)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

The recent advances in benzimidazole-based antimicrobials and antitubercular agents

Future Journal of Pharmaceutical Sciences
Background Benzimidazole, a fused heterocyclic compound, has emerged as a privileged structure in medicinal chemistry due to its broad spectrum of biological activities, particularly in antimicrobial and antitubercular (anti-TB) applications.
Abdalrahman Tarek, Maiy Y. Jaballah, Eman Z. Elrazaz, Nermin Samir   +3 more
doaj   +1 more source

Evaluation of structurally different benzimidazoles as priming agents, plant defence activators and growth enhancers in wheat

BMC Chemistry, 2019
Priming is a valuable, facile and well-established technique used to enhance seed quality to achieve rapid germination, establishment of stress resistance and improvement of crop yields.
Arruje Hameed, Amjad Hameed, Tahir Farooq, Razia Noreen, Sadia Javed, Shaheera Batool, Ashfaq Ahmad, Tahsin Gulzar, Matloob Ahmad   +8 more
doaj   +1 more source

2-Trifluoromethyl-1H-benzimidazole [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
The asymmetric unit of the title compound, C(8)H(5)F(3)N(2), consists of two half-mol-ecules, one lies on a mirror plane and the other is generated by twofold rotation symmetry, with the axis running through the trifluoro-methyl C atom and the attached benzimidazole C atom.
openaire   +3 more sources

Sensitivity of Irish Pyrenopeziza brassicae populations to methyl benzimidazole carbamate (MBC), quinone outside inhibitor (QoI) and succinate dehydrogenase inhibitor (SDHI) fungicides

Pest Management Science, EarlyView.
For three collections of Irish Pyrenopeziza brassicae populations fungicide sensitivity status to methyl benzimidazole carbamate (MBC), quinone outside inhibitor (QoI) and succinate dehydrogenase inhibitor (SDHI) fungicides was determined using sensitivity screening in vitro. Molecular mechanisms of insensitivity have been identified for MBC and QoI in
Diana E Bucur, Yong‐Ju Huang, Bruce DL Fitt, Steven Kildea   +3 more
wiley   +1 more source

Recent advances in the synthetic transformation of benzimidazole scaffolds as privileged pharmacophores for cancer chemotherapy (2020–present)

Journal of Saudi Chemical Society
Benzimidazole is a fused heterocycle of benzene and imidazole rings. It has attracted marked attention as a privileged pharmacophore with a wide spectrum of biological activities-bioactivities among which anticancer therapeutic potential is most studied.
Ali Irfan, Mahwish Arshad, Sami A. Al-Hussain, Ayesha Amin, Iqra Nasim, Sadaf Ahmad, Bakar Bin Khatab Abbasi, Aamal A. Al-Mutairi, Tahira Khalid, Magdi E. A. Zaki   +9 more
doaj   +1 more source

Relationship between intraocular pressure lowering effect and chemical structure of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole derivatives

Data in Brief, 2018
This article contains data that relate to the study carried out in the work of Marcus et al. (2018) [1]. Data represent an information about pharmacophore analysis of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole derivatives and results of
Pavel Vassiliev, Igor Iezhitsa, Renu Agarwal, Adrian Julian Marcus, Alexander Spasov, Olga Zhukovskaya, Vera Anisimova   +6 more
doaj   +1 more source

Synthesis, antimicrobial and antiproliferative activities of new self-assembly benzimidazole-bridged aren ruthenium rectangles in human breast cancer cells

, 2021
Ersin Orhan, Görkem Dülger, Merve Alpay, Nilüfer Öksüz, Başaran Dülger   +4 more
openalex   +2 more sources

Indocyanine Green–Inspired Polymeric Chromophores With Intrinsic Photostability for Near‐Infrared Imaging

Small, EarlyView.
Indocyanine green (ICG) is widely used for near‐infrared imaging but suffers from poor photostability. Here, an indocyanine green–inspired polymeric NIR chromophore is introduced, exhibiting intrinsically enhanced photostability and biocompatibility.
Su Bin Lee, Minsuk Choi, Young Hoon Son, Minseo Kim, Hye Sun Park, Seung Hyeon Kim, Ogabek Oybek Ugli Juraev, Hyocheol Jung, Hyoung Eun Bae, Ji‐Eun Jeong, Young‐Jae Jin, Jin Chul Kim, Sung‐Jin Park, Sang Hwan Nam, Young Il Park   +14 more
wiley   +1 more source

Antifungal benzimidazoles disrupt vasculature by targeting one of nine β-tubulins [PDF]

, 2020
Riddhiman K. Garge, Hye Young Ji, Chanjae Lee, Jimmy Gollihar, Aashiq H. Kachroo, John B. Wallingford, Edward M. Marcotte   +6 more
openalex   +1 more source