Results 101 to 110 of about 35,659 (254)

Biologically Active Benzimidazole Hybrids as Cancer Therapeutics: Recent Advances

Pharmaceuticals
Cancer is a highly significant medical concern, as it is the second most prevalent cause of mortality after cardiovascular diseases. It arises due to dysregulated cell cycle control, leading to a gradual decline in cellular differentiation and ...
Mohamed A. S. Badawy, Stefan Bräse, Taha F. S. Ali, Mohamed Abdel-Aziz, Hamdy M. Abdel-Rahman   +4 more
doaj   +1 more source

Applicability of a Simple Decay Function to Describe Fire‐Protective Fabrics' Aging Behavior

Journal of Polymer Science, EarlyView.
The simple decay function offers a mean to quantitatively analyze and contrast the aging behavior of various fire‐protective fabrics under a wide range of aging conditions. ABSTRACT Predicting the effect of aging conditions on materials' performance is a challenging yet critical task.
Patricia I. Dolez, Kaoru Wakatsuki, Md. Saiful Hoque, Laura Munevar‐Ortiz   +3 more
wiley   +1 more source

Unraveling the mechanisms of benzimidazole resistance in hookworms: A molecular docking and dynamics study

Journal of Genetic Engineering and Biotechnology
Background: Benzimidazole resistance is an emerging challenge among parasitic helminths. It is caused by single nucleotide polymorphisms (SNPs) in specific loci in helminths’ β-tubulin genes.
Jan Clyden B. Tenorio, Muhammad Fikri Heikal, Alok Kafle, Mark Andrian B. Macalalad, Fredmoore L. Orosco, Prasert Saichua, Sutas Suttiprapa   +6 more
doaj   +1 more source

Sensitivity of Irish Pyrenopeziza brassicae populations to methyl benzimidazole carbamate (MBC), quinone outside inhibitor (QoI) and succinate dehydrogenase inhibitor (SDHI) fungicides

Pest Management Science, EarlyView.
For three collections of Irish Pyrenopeziza brassicae populations fungicide sensitivity status to methyl benzimidazole carbamate (MBC), quinone outside inhibitor (QoI) and succinate dehydrogenase inhibitor (SDHI) fungicides was determined using sensitivity screening in vitro. Molecular mechanisms of insensitivity have been identified for MBC and QoI in
Diana E Bucur, Yong‐Ju Huang, Bruce DL Fitt, Steven Kildea   +3 more
wiley   +1 more source

Disease control in oilseed rape: Current insights and perspectives for next‐generation integrated pest management

Pest Management Science, EarlyView.
Winter oilseed rape in Europe suffers frequent pathogen losses. This review outlines key integrated pest management (IPM) strategies, rotation, residue and tillage management, optimized sowing, resistance, and targeted fungicides supported by forecasting.
Jon S West, Małgorzata Jędryczka, Nazanin Zamani‐Noor   +2 more
wiley   +1 more source

THE ACTION OF BENZIMIDAZOLE ON ENZYMATIC ADAPTATION

, 1955
The adaptive formation of formic hydrogenlyase in E. coli and of the enzymes oxidizing benzoate, malonate, and L-tyrosine in P. fluorescens is inhibited by benzimidazole. In one strain of E.
Enid Pascoe, Donn J. Kushner
core   +1 more source

Resistance to thiophanate‐methyl and azoxystrobin in Colletotrichum species from Brazilian grapes

Pest Management Science, EarlyView.
First report of resistance to both quinone outside inhibitor (QoI; azoxystrobin) and methyl benzimidazole carbamate (MBC; thiophanate‐methyl) fungicides in Colletotrichum isolates associated with grapevine in Brazil. Abstract BACKGROUND Grape ripe rot (GRR) caused by Colletotrichum species can cause yield loss in vineyards in Southern and Northeast ...
Daniel Ricardo Maass Steiner, Camila Iavorski Zela, Debora Franco de Oliveira, Jhulia Gelain, Guido Schnabel, Louise Larissa May De Mio   +5 more
wiley   +1 more source

A novel thromboxane receptor antagonist, nstpbp5185, inhibits platelet aggregation and thrombus formation in animal models

, 2017
A novel benzimidazole derivative, nstpbp5185, was discovered through in vitro and in vivo evaluations for antiplatelet activity. Thromaboxane receptor (TP) is important in vascular physiology, haemostasis and pathophysiological thrombosis.
林淑華;彭惠琴;黃德富, Huang, Shiu-Wen;Kuo, Heng-Lan;Hsu, Ming-Tsung;Tseng, Yufeng Jane;Lin, Shu-Wha;Kuo, Sheng-Chu;Peng, Hui-Chin;Lien, Jin-Cherng;Huang, Tur-Fu   +1 more
core   +1 more source

The photoswitchable ABAMIs for the future regulation of GWT1 in a spatiotemporal level

Smart Molecules, EarlyView.
The GWT1‐targeted azobenzene‐aminopyridine derivatives (ABAMIs), sensitive to the light at wavelengths from 365 to 520 nm, are separately developed as photochromic ligands to regulate bioactivity as well as the GWT1 functions. These molecules are smart tools in photopharmacological studies, giving an innovative method for understanding functional GWT1 ...
Qian Ding, Zongying Li, Zaiwei Xiao, Siting Zhang, Zimai Liu, Xiaoguang Shao, Zhong Li, Wen Fu, Xusheng Shao   +8 more
wiley   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source