Results 101 to 110 of about 37,139 (276)

Recent advances in the synthetic transformation of benzimidazole scaffolds as privileged pharmacophores for cancer chemotherapy (2020–present)

Journal of Saudi Chemical Society
Benzimidazole is a fused heterocycle of benzene and imidazole rings. It has attracted marked attention as a privileged pharmacophore with a wide spectrum of biological activities-bioactivities among which anticancer therapeutic potential is most studied.
Ali Irfan, Mahwish Arshad, Sami A. Al-Hussain, Ayesha Amin, Iqra Nasim, Sadaf Ahmad, Bakar Bin Khatab Abbasi, Aamal A. Al-Mutairi, Tahira Khalid, Magdi E. A. Zaki   +9 more
doaj   +1 more source

Biologically Active Benzimidazole Hybrids as Cancer Therapeutics: Recent Advances

Pharmaceuticals
Cancer is a highly significant medical concern, as it is the second most prevalent cause of mortality after cardiovascular diseases. It arises due to dysregulated cell cycle control, leading to a gradual decline in cellular differentiation and ...
Mohamed A. S. Badawy, Stefan Bräse, Taha F. S. Ali, Mohamed Abdel-Aziz, Hamdy M. Abdel-Rahman   +4 more
doaj   +1 more source

Highly efficient blue crystalline organic light‐emitting diodes enabled by a hot exciton sensitizer PyPO

FlexMat, EarlyView.
Two different sensitization structures (hot exciton sensitizer type and exciton nanoaggregate type) were integrated into crystalline host matrix. The resulting crystalline organic light‐emitting diodes exhibit low Joule heat loss ratio and high photon output.
Hao Hu, Bo Yu, Ping Lu, Feng Zhu, Donghang Yan   +4 more
wiley   +1 more source

Tổng hợp dẫn xuất benzimidazole trong điều kiện không dung môi

Tạp chí Khoa học Đại học Cần Thơ
Benzimidazole và các dẫn xuất của chúng được xem là khung sườn quan trọng trong các ngành công nghiệp dược phẩm, phẩm nhuộm, hóa chất nông nghiệp và vật liệu.
Hồng Vinh Quang, Nguyễn Thị Thạch Thảo, Mai Thị Kiều Trang, Phan Tuyết Nữ, Lê Thị Xuân Lộc, Trần Quang Đệ, Bùi Thị Bửu Huê   +6 more
doaj   +1 more source

2,3-Dihydro-2-oxo-1H-benzimidazole-1-carboxamides with Selective Affinity for the 5-HT₄ Receptor:  Synthesis and Structure−Affinity and Structure−Activity Relationships of a New Series of Partial Agonist and Antagonist Derivatives

, 2016
A series of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxamide derivatives bearing a piperazine moiety was synthesized. Their in vitro 5-HT4, 5-HT3, and D2 receptors affinities were evaluated by radioligand binding assay.
Inés Tapia (3023391), Ramón Mosquera (3019131), Pedro Luis López-Tudanca (3023385), Aurelio Orjales (3019128), Luisa Alonso-Cires (3023394), Ana Innerárity (3023388), Luis Labeaga (3019137)   +6 more
core   +1 more source

Unraveling the mechanisms of benzimidazole resistance in hookworms: A molecular docking and dynamics study

Journal of Genetic Engineering and Biotechnology
Background: Benzimidazole resistance is an emerging challenge among parasitic helminths. It is caused by single nucleotide polymorphisms (SNPs) in specific loci in helminths’ β-tubulin genes.
Jan Clyden B. Tenorio, Muhammad Fikri Heikal, Alok Kafle, Mark Andrian B. Macalalad, Fredmoore L. Orosco, Prasert Saichua, Sutas Suttiprapa   +6 more
doaj   +1 more source

THE ACTION OF BENZIMIDAZOLE ON ENZYMATIC ADAPTATION

, 1955
The adaptive formation of formic hydrogenlyase in E. coli and of the enzymes oxidizing benzoate, malonate, and L-tyrosine in P. fluorescens is inhibited by benzimidazole. In one strain of E.
Enid Pascoe, Donn J. Kushner
core   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Band Engineering of Benzothiadiazole‐Derived Metal‐Organic Frameworks for Photocatalytic Organic Transformations

National Materials, EarlyView.
BTID‐functionalized metal‐organic frameworks provide a modular platform for tailoring photocatalytic electronic structures through acceptor‐linker engineering. By correlating band alignment, charge‐transfer characteristics, and reactive oxygen species generation, this review highlights design principles that enable efficient visible‐light‐driven ...
Xin Li, Long‐Shuang Chen, Meng‐Hao Li, Ying‐Wei Yang   +3 more
wiley   +1 more source

Resistance to thiophanate‐methyl and azoxystrobin in Colletotrichum species from Brazilian grapes

Pest Management Science, EarlyView.
First report of resistance to both quinone outside inhibitor (QoI; azoxystrobin) and methyl benzimidazole carbamate (MBC; thiophanate‐methyl) fungicides in Colletotrichum isolates associated with grapevine in Brazil. Abstract BACKGROUND Grape ripe rot (GRR) caused by Colletotrichum species can cause yield loss in vineyards in Southern and Northeast ...
Daniel Ricardo Maass Steiner, Camila Iavorski Zela, Debora Franco de Oliveira, Jhulia Gelain, Guido Schnabel, Louise Larissa May De Mio   +5 more
wiley   +1 more source