Results 111 to 120 of about 37,139 (276)

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Synthesis and antimicrobial activity of certain benzimidazole and fused benzimidazole derivatives

, 2010
1515-1525Novelbenzimidazole and fused benzimidazole derivatives such as triazinobenzimidazoles 3a-f, oxadia-zolylthio­methyl-1H-benzimidazoles5a-e, triazolylthiomethyl-1H-benzimidazoles7a,b, thiazolidinyl-methyl-1H-benzimidazoles 9a-e and ...
Farahat, Abdelbasset A, Eisa, Hassan M, Barghash, Alaa-eldin M, Badr, Sahar M   +3 more
core  

Cytogenotoxic Effects of Fluopyram in Allium cepa Root Cells Involving Microtubule Disruption

Environmental Toxicology, EarlyView.
ABSTRACT Fluopyram is a next‐generation fungicide widely used in agriculture; however, its persistence in soils and mobility toward aquatic systems have raised concerns regarding potential ecotoxicological risks. This study evaluated the cytogenotoxic effects of a commercial fluopyram‐based pesticide formulation on Allium cepa root meristem cells ...
Carlos Filipe Camilo‐Cotrim, Natanael Alves da Silva, Gabriela Gomes Lima, Igor Rodrigues Vasconcelos, Luciana Souza Ondei, Elisa Flávia Luiz Cardoso Bailão, Antônio Sérgio Nakao de Aguiar, Marcelino Benvindo‐Souza, Leonardo Luiz Borges, Virgínia Damin, Luciane Madureira Almeida   +10 more
wiley   +1 more source

Serious adverse events reported with benzimidazole derivatives: A disproportionality analysis from the World Health Organization's pharmacovigilance database.

PLoS Neglected Tropical Diseases
BackgroundBenzimidazole derivatives are widely used anthelmintic drugs, particularly in mass campaigns for intestinal parasitosis treatment. Despite their generally good safety profile, serious adverse reactions have been reported.
Pamella Modingam, Jean-Luc Faillie, Jérémy T Campillo   +2 more
doaj   +1 more source

A review on biologically important benzimidazole derivatives

Results in Chemistry
Chemists have long been interested in the synthesis of benzimidazole derivatives, resulting in numerous studies on this heterocyclic compound. Its exceptional therapeutic efficacy in treating diseases has attracted further attention.
Vijayabharathi Sundharaj, V. Vijayakumar, S. Sarveswari   +2 more
doaj   +1 more source

Benzimidazole Anthelmintic Compounds Albendazole and Fenbendazole Show Distinct Toxicity on the Nitrogen Fixing Bacterium Mesorhizobium loti and Its Symbiosis With Lotus japonicus

Environmental Toxicology, EarlyView.
ABSTRACT Veterinary medicines, which reach the soil mostly through the application of contaminated manures, can affect beneficial soil microorganisms, such as nitrogen‐fixing rhizobia bacteria, which engage in important symbiotic associations with plants.
Polyxeni Gorgia, Stathis Lagos, Christina N. Nikolaou, Nikoleta Basdeki, Christos Papadopoulos, Dimitrios G. Karpouzas, Daniela Tsikou   +6 more
wiley   +1 more source

Substitutions of organopalladium(II) species with benzimidazole derivatives

, 2004
The [Pd(cod)(cotl)]ClO4 complex (cod = cycloocta-1,5-diene; cotl = cyclooctenyl, C18H13 -) undergoes substitutions with new Schiff base ligands containing benzimidazole L [L = 2-(2′-N-n-propylidenephenyl)benzimidazole (L1); 2(2′-N-i-propylidenephenyl ...
Bhattacharjee, R., Gowda, N.M.N., Gayathri, V.   +2 more
core   +1 more source

Protodesnitazene: The identification and tissue distribution of a new nitazene

Journal of Forensic Sciences, EarlyView.
Abstract Multiple new analogues from the 2‐benzyl benzimidazole or “nitazene” class of drugs have emerged on the drug market in recent years. Nitazenes are highly potent μ‐opioid receptor agonists that present a substantial public health concern due to their elevated risk of severe toxicity in overdose and their significant potential for misuse.
Andrew Griffiths, Nathan Milne, Michelle Johnston, Karen Blakey, Rogan Scott   +4 more
wiley   +1 more source

SYNTHESIS OF SOME PYRIDO-BENZIMIDAZOLE AND PYRAZINO-BENZIMIDAZOLE DERIVATIVES AND THEIR ANTIFUNGAL ACTIVITY

, 1995
Some 2-aryl-4-hydroxypyrido[1,2-a]benzimidazole and 1-substituted 3-arylpyrazino-[1,2-a]benzimidazole derivatives were synthesized using 1-(2-arylethan-2-on)-2-acylbenzimidazole derivatives as starting materials.
GUVEN, K, DEMIRAYAK, S
core