Results 111 to 120 of about 35,659 (254)

Membranas de polieletrólitos com características de condução protônica: obtenção, caracterização e avaliação da eficiência em células a combustível [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-graduação em QuímicaMembranas compósitas com características de condutividade protônica tem sido estudadas como uma alternativa para ...
Oliveira, Paula Nunes de
core  

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Serious adverse events reported with benzimidazole derivatives: A disproportionality analysis from the World Health Organization's pharmacovigilance database.

PLoS Neglected Tropical Diseases
BackgroundBenzimidazole derivatives are widely used anthelmintic drugs, particularly in mass campaigns for intestinal parasitosis treatment. Despite their generally good safety profile, serious adverse reactions have been reported.
Pamella Modingam, Jean-Luc Faillie, Jérémy T Campillo   +2 more
doaj   +1 more source

A review on biologically important benzimidazole derivatives

Results in Chemistry
Chemists have long been interested in the synthesis of benzimidazole derivatives, resulting in numerous studies on this heterocyclic compound. Its exceptional therapeutic efficacy in treating diseases has attracted further attention.
Vijayabharathi Sundharaj, V. Vijayakumar, S. Sarveswari   +2 more
doaj   +1 more source

Photoactivation of Electron Donor–Acceptor Complexes Enables Deoxygenative Hydrogenation and Deuteration

Transformative Chemistry, EarlyView.
A photoinduced, NHC‐borane‐enabled radical deoxygenative hydrogenation featuring mild reaction conditions and excellent functional group tolerance has been developed. The reaction proceeds through a novel EDA complex photoactivation pathway. To explore the potential of NHC‐boranes in deuteration reactions, we developed a novel photoinduced protocol for
Mengqing Zhang, Changlei Zhu, Jingjing Wu   +2 more
wiley   +1 more source

Cytogenotoxic Effects of Fluopyram in Allium cepa Root Cells Involving Microtubule Disruption

Environmental Toxicology, EarlyView.
ABSTRACT Fluopyram is a next‐generation fungicide widely used in agriculture; however, its persistence in soils and mobility toward aquatic systems have raised concerns regarding potential ecotoxicological risks. This study evaluated the cytogenotoxic effects of a commercial fluopyram‐based pesticide formulation on Allium cepa root meristem cells ...
Carlos Filipe Camilo‐Cotrim, Natanael Alves da Silva, Gabriela Gomes Lima, Igor Rodrigues Vasconcelos, Luciana Souza Ondei, Elisa Flávia Luiz Cardoso Bailão, Antônio Sérgio Nakao de Aguiar, Marcelino Benvindo‐Souza, Leonardo Luiz Borges, Virgínia Damin, Luciane Madureira Almeida   +10 more
wiley   +1 more source

Benzimidazole Anthelmintic Compounds Albendazole and Fenbendazole Show Distinct Toxicity on the Nitrogen Fixing Bacterium Mesorhizobium loti and Its Symbiosis With Lotus japonicus

Environmental Toxicology, EarlyView.
ABSTRACT Veterinary medicines, which reach the soil mostly through the application of contaminated manures, can affect beneficial soil microorganisms, such as nitrogen‐fixing rhizobia bacteria, which engage in important symbiotic associations with plants.
Polyxeni Gorgia, Stathis Lagos, Christina N. Nikolaou, Nikoleta Basdeki, Christos Papadopoulos, Dimitrios G. Karpouzas, Daniela Tsikou   +6 more
wiley   +1 more source

Trends in new psychoactive substance poisonings in the Netherlands: A 14‐year retrospective analysis (2012–2025)

Addiction, EarlyView.
Abstract Background and aims Data on the presence of new psychoactive substances (NPS) mainly originate from drug‐checking, law enforcement and wastewater analysis sources, while data on NPS poisonings are scarce. In Europe, the documented incidence rate of NPS poisonings is highest in the Netherlands.
Johanna J. Nugteren‐van Lonkhuyzen, Irma S. van den Hengel‐Koot, Claudine C. Hunault, Dylan W. de Lange, Antoinette J. H. P. van Riel, Laura Hondebrink   +5 more
wiley   +1 more source

Antiproliferative effect of silver compounds containing benzimidazole ring

Trakya University Journal of Natural Sciences
With its significant biological activities, the benzimidazole nucleus is a crucial pharmacophore in medicine. Recent studies have focused on the synthesis and biological activity of benzimidazole compounds.
Senem Akkoç, Buket Banu Özkan, Dilek Bahar   +2 more
doaj   +1 more source

Anthelmintic resistance in sheep nematodes in Australia: a compilation of recent test results

Australian Veterinary Journal, EarlyView.
Objective The results of recent faecal egg count reduction tests (FECRTs) were collated to provide an indication of the prevalence and severity of anthelmintic resistance in sheep nematodes across Australia and of changes in comparison to earlier testing reports.
RB Besier, NM Rolls
wiley   +1 more source