Results 121 to 130 of about 17,199 (170)

Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disorder, recognized as the most prevalent form of dementia. It is characterized by multiple pathological processes, including amyloid‐beta accumulation, neurofibrillary tangles, and neuroinflammation. The therapeutic efficacy of traditional single‐target drugs has been
Md Saad Hossain, Md Hamed Hussain
wiley   +1 more source

Benzimidazole(s): synthons, bioactive lead structures, total synthesis, and the profiling of major bioactive categories. [PDF]

RSC Adv
Aroua LM, Alminderej FM, Almuhaylan HR, Alosaimi AH, Medini F, Mohammed HA, Almahmoud SA, Khan RA, Mekni NH.   +8 more
europepmc   +1 more source

Boosting the Stability of FAPbI3 Perovskite Nanocrystal Near‐Infrared Light‐Emitting Diodes with Aromatic Ligands and Organic Host Dispersion

Small, Volume 21, Issue 31, August 7, 2025.
Aromatic ligand exchange with 2,2‐diphenylethylamine (DPEA) and dispersion in π‐conjugated organic hosts enhance the photostability and device lifetime of near‐infrared FAPbI3 perovskite nanocrystal LEDs. This strategy suppresses energy transfer, improves quantum efficiency, and extends operational stability, offering a robust platform for stable ...
Haruka Abe, Mizuho Uwano, Ryota Kobayashi, Kohei Narazaki, Takuya Akiyama, Yuta Ito, Daisuke Yokota, Takao Oto, Shotaro Nishitsuji, Ryohei Yamakado, Takayuki Chiba   +10 more
wiley   +1 more source

Liquid Coordination Polymers with Anhydrous Proton Conductivity

Angewandte Chemie, Volume 137, Issue 30, July 21, 2025.
Functional liquid coordination polymers near ambient conditions are prepared by introducing H3PO4 as a network modifier. This process disrupts extended coordination networks, producing a stable liquid. Liquid properties are controlled by tuning the ratio of network modifiers, resulting in anhydrous proton conductivity up to 27 mS cm−1 at 353 K and ...
Nattapol Ma, Soracha Kosasang, Satoshi Horike, Hiroki Yamada   +3 more
wiley   +2 more sources

Experimental and theoretical evaluation of the corrosion inhibition performance of two benzimidazole derivatives for low carbon steel in acidic solution. [PDF]

RSC Adv
Xhanari K, Farruku M, Berisha A, Xhaxhiu K, Canaj J, Seiti B, Kokalari E, Lame A.   +7 more
europepmc   +1 more source

A Comprehensive Narrative Review of Protonitazene: Pharmacological Characteristics, Detection Techniques, and Toxicology

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 2, August 2025.
ABSTRACT Protonitazene (PNZ) is a synthetic opioid emerging in Europe, Australia, North America and South America with a rapidly increasing number of intoxications. To describe PNZ's pharmacological characteristics, detection methods and the clinical presentation and management of PNZ intoxications, the PubMed database was searched for original ...
Jake Verbeek, David J. Brinkman
wiley   +1 more source

Shaping of a Reactive Manganese Catalyst Enables Access to Polyfunctionalized Cyclohexanes via Enantioselective C(sp3)─H Bond Oxidation of 1,3‐meso Diethers

Angewandte Chemie, Volume 137, Issue 30, July 21, 2025.
Structural shaping of a highly reactive chiral Mn‐oxo species translates into exceptionally enantioselective C─H oxidation catalyst of cyclohexyl 1,3‐meso diethers (up to >99% ee) leading to polyfunctionalized cyclohexanes. Abstract Chiral polyoxygenated cyclohexanes are valuable constituents of biologically relevant products.
Andrea Palone, Arnau Call, Aleria Garcia‐Roca, Josep M. Luis, Matthew S. Sigman, Massimo Bietti, Cristina Nevado, Miquel Costas   +7 more
wiley   +2 more sources

Comprehensive Survival Analysis of Alveolar Echinococcosis Patients, University Hospital Zurich, Zurich, Switzerland, 1973-2022. [PDF]

Emerg Infect Dis
Deibel A, Kindler Y, Mita R, Ghafoor S, Meyer Zu Schwabedissen C, Brunner-Geissmann B, Schweiger A, Grimm F, Reinehr M, Weber A, Reiner CS, Kremer AE, Petrowsky H, Clavien PA, Deplazes P, von Felten S, Müllhaupt B.   +16 more
europepmc   +1 more source

Repurposing of FDA‐Approved Drugs to Disrupt Iron Uptake in Mycobacterium abscessus: Targeting Salicylate Synthase as a Novel Approach

Chemical Biology &Drug Design, Volume 106, Issue 2, August 2025.
A drug repurposing strategy was applied against M. abscessus, through a virtual screening of FDA approved drugs on salicylate synthase. Eleven potential ligands were found; among these, three were confirmed as potent inhibitors of the enzyme. ABSTRACT Non‐tuberculous mycobacteria (NTM) are opportunistic pathogens that lead to severe, persistent ...
Giovanni Stelitano, Christian Bettoni, Matteo Mori, Mario Cocorullo, Andrea Tresoldi, Fiorella Meneghetti, Stefania Villa, Laurent R. Chiarelli   +7 more
wiley   +1 more source

Structural Origin of Spin‐Orbit Splitting of 1P Orbitals of Icosahedral Au13 Superatom Protected by Ligands

Angewandte Chemie, Volume 137, Issue 30, July 21, 2025.
The spin‐orbit (SO) splitting of the superatomic 1P orbitals in thiolate‐protected Au13 superatoms were investigated. Cryogenic anion photoelectron spectroscopy and fully relativistic calculation including SO coupling revealed the 1P orbitals of the Au13 and Au@Ag12 superatomic cores undergo SO splitting, while not in the Ag13 core.
Shun Ito, Kiichirou Koyasu, Tatsuya Tsukuda   +2 more
wiley   +2 more sources