Results 151 to 160 of about 37,139 (276)

Direct Access to Chiral Piperidines by Enantioselective HAT‐Initiated C(sp3)─H Oxidation

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
The direct desymmetrization of piperidines is achieved through manganese‐catalyzed enantioselective α‐C(sp3)─H oxidation with hydrogen peroxide, affording versatile chiral N,O‐acetals in good yields and with high enantio‐ and diastereoselectivity. These intermediates provide access to diverse functionalized piperidines with retention of chirality ...
Sethuraman Muthuramalingam, Josep M. Luis, Arnau Call, Quentin Lefebvre, Matthew S. Sigman, Miquel Costas   +5 more
wiley   +2 more sources

Fungicide Non‐Target Effects Cause Reduced Sawfly Herbivory in Treated and Neighbouring Strawberry Plants

Entomologia Experimentalis et Applicata, Volume 174, Issue 11, Page 1314-1321, November 2026.
Application of the fungicide Switch 62.5 WG in garden strawberry (Fragaria × ananassa), targeting Botrytis cinerea, reduced sawfly (Cladius spp.) herbivory by up to 94% and improved fruit quality. This non‐target effect also spilled over to neighbouring untreated plants, lowering damage by 46%.
Esther Kuper, Mudassir Iqbal, Åsa Lankinen, Erik Andreasson, Johan A. Stenberg   +4 more
wiley   +1 more source

Vitamin B12‐Functionalized Nanogels for pH‐, and Redox‐Responsive Doxorubicin Delivery

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
A polymerizable 5′‐modified vitamin B12‐monomer enables the covalent incorporation of B12 into pH‐ and redox‐responsive nanogels for targeted doxorubicin delivery. The nanogels exhibit glutathione‐triggered drug release, potent antiproliferative activity against HT‐29 cancer cells, and strongly reduced cytotoxicity toward healthy cells.
Serife Dagdelen, Paula D. Mestizo, Marcin Mackiewicz, Agnieszka Kurdyn, Ewa Augustin, Marcin Karbarz, Felix Zelder   +6 more
wiley   +1 more source

Synthesis of Nitrogen‐Containing Heterocyclic Scaffolds and Applications in Scaffold Hopping: Development of an Aripiprazole Analog

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
A series of 12 novel fused [6,6] saturated and unsaturated nitrogen bicycles is synthesized in three to five steps and expands the CRAFT library's fragment space. A 2,6‐naphthyridin‐3‐ol core replaces the dihydroquinolinone scaffold of aripiprazole, a scaffold‐hopping strategy.
Temitayo Omowumi Alegbejo Price, Pieterjan Winant, Paulo Eliandro da Silva Júnior, Shaiani Maria Gil de Melo, Pedro Henrique Gobira, Julia Possamai Gimenes, Pedro Tenório Teixeira Fernandes Leite, Vinícius Gonçalves Maltarollo, Gustavo Henrique Goulart Trossini, A. Ganesan, Sâmia Regiane Lourenço Joca, Wim Dehaen, Flavio da Silva Emery   +12 more
wiley   +1 more source

Riluzole‐Derived Benzo[d]thiazoles as CK1δ Inhibitors for Amyotrophic Lateral Sclerosis‐Related Neurodegeneration

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Riluzole metabolism guided the design of benzo[d]thiazole inhibitors of casein kinase 1 delta (CK1δ), a kinase linked to amyotrophic lateral sclerosis (ALS). Docking supported ATP site recognition by the hydroxylamine metabolite and hydrazine analogues, leading to compounds showing improved potency and retained predicted blood brain barrier ...
Simone Adorinni, Ilenia Grieco, Stefano Morasso, Michelle Fornasier, Gianluca Novello, Veronica Salmaso, Loreto Martínez‐González, Eleonora Cescon, Davide Bassani, Giovanni Adriano Bassan, Teresa Gianferrara, Filippo Prencipe, Veronika Kost, Tatiana Da Ros, Paola Storici, Ana Martinez, Giampiero Spalluto, Stefano Moro, Stephanie Federico   +18 more
wiley   +1 more source

Contrasting Isotype-1 β-Tubulin Genotypes at Benzimidazole-Resistance Loci in <i>Haemonchus contortus</i> from Yining and Tacheng, Northwestern Xinjiang, China. [PDF]

Pathogens
Tuersong W, Xuekelaiti D, Maimaiti A, Li J, Guo Q.   +4 more
europepmc   +1 more source

Synthesis and Binding Affinity Insights of 2-Phenyl-1H-Benzimidazole Inhibitors Targeting FTO by Spectroscopic Characterization and Molecular Docking. [PDF]

J Mol Recognit
Wang J, Chen Y, Wang R.
europepmc   +1 more source

Flavin Catalysts in Organic Synthesis

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Flavins and their congeners are potent catalysts for organic synthesis inspired by enzymatic transformations. In addition to catalysis in the flavin ground state via covalent intermediates, the excited singlet and triplet states unlock applications including photooxidation, photoreduction, and energy transfer via sensitization.
Jan Freudenberg, Golo Storch
wiley   +2 more sources

Twenty Years of Benzimidazole Scaffold Optimization in Antiparasitic Drug Discovery. [PDF]

ChemMedChem
Kondža M, Rezić V, Drmač D.
europepmc   +1 more source

Pd/C‐Catalyzed Denitrogenative Dehydrogenation of Primary Azides to Nitriles in Batch and Continuous Flow

Advanced Synthesis &Catalysis, Volume 368, Issue 20, 16 October 2026.
A practical Pd/C‐catalyzed conversion of primary azides to nitriles was investigated under batch and continuous‐flow conditions. This transformation proceeds via net denitrogenative dehydrogenation without an external carbon source. The addition of methyl acrylate or styrene suppresses the formation of reductive byproducts, providing selective access ...
Naoya Sakurada, Takanori Kitazono, Hikaru Naito, Seiya Ootori, Tsuyoshi Yamada, Tomohiro Ichikawa, Takashi Shigeta, Takashi Ikawa, Hironao Sajiki   +8 more
wiley   +1 more source