Results 151 to 160 of about 35,659 (254)

Clinical Molecular Investigation of Encephalitozoon cuniculi in Pet Rabbits: Early Detection of Potential Risk for Animal and Human Infection

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
This study assesses the presence, genotypes and clinical signs of E. cuniculi infection in pet rabbits in Slovenia. Molecular analysis reveals the presence of E. cuniculi DNA (Genotype I) in 14.98% rabbit urine samples, mostly in rabbits with signs of urinary tract disorders.
Maruša Škrbec, Brigita Slavec, Nina Kočar, Katarina Modrijan, Urška Kuhar, Marko Kolenc, Alenka Dovč, Olga Zorman Rojs, Jožko Račnik   +8 more
wiley   +1 more source

Structural Modifications of Hybrid O-Alkylsulfonyl-β-(Benzimidazol-1-yl)propioamidoximes as a Pathway to the Antimicrobial, Antifungal and Antidiabetic Drugs. [PDF]

Int J Mol Sci
Kayukova L, Vologzhanina A, Dubasova E, Seidakhmetova R, Yerlanuly A, Sartoyeva A, Malmakova A.   +6 more
europepmc   +1 more source

Drug Resistance Assessment of Commonly Used Anthelmintics, and Their Combination Effect in Naturally Infected Sheep: The Case of Kaffa Zone, Southwestern Ethiopia

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
This study evaluated the efficacy of widely used commercial anthelmintics and examined whether combining different drug classes enhances their effectiveness in naturally infected sheep in the Kaffa Zone. This study suggest the presence of emerging anthelmintic resistance to albendazole and tetramisole in the study area and highlight the potential ...
Nahom Belay, Asrat Arke, Lamrot Tesfaye
wiley   +1 more source

Alveolar echinococcosis. [PDF]

Curr Opin Infect Dis
Stojković M, Junghanss T, Gehling KG.
europepmc   +1 more source

YK‐4‐250, a synthetic telmisartan–tempol conjugate: crystal structure of a stabilized free radical containing an angiotensin AT1 receptor inhibitor

Acta Crystallographica Section C, Volume 82, Issue 9, Page 547-552, September 2026.
The first crystal structure of the telmisartan–tempol conjugate YK‐4‐250 is reported, revealing the intramolecular C–H…π interactions that stabilize the nitroxide radical while preserving the angiotensin AT1 receptor antagonist pharmacophore.We report the first crystal structure of the telmisartan–tempol conjugate 2,2,6,6‐tetramethyl‐1‐(λ′‐oxidaneyl ...
Simon Friedrich, Yali Kong, Faik N. Musayev, Milton L. Brown, B. Frank Gupton   +4 more
wiley   +1 more source

Iso‐ and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On‐Target Activity Through Scaffold Decoration and In Situ Warhead Generation

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
We explore covalent allosteric targeting of MGL regulatory cysteines using iso‐ and benzisothiazolinone scaffolds. Combining mechanism‐based warhead release with structure‐guided scaffold decoration to improve molecular recognition, this study probes strategies to achieve selective on‐target engagement beyond the catalytic site. Monoacylglycerol lipase
Edoardo Rocca, Annalida Bedini, Laura Scalvini, Francesca Galvani, Riccardo Castelli, Lorenzo Sarcone, Adriano Recchia, Fabiola Fanini, Adren Tran, Silvia Rivara, Gilberto Spadoni, Daniele Piomelli, Marco Mor   +12 more
wiley   +1 more source

From Scaffold to Therapy: Benzimidazole Pharmacophore Evolution in Breast Cancer Research. [PDF]

Chem Biodivers
Kaur A, Singh G.
europepmc   +1 more source

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source

PIII/PV Redox Organocatalysis Enables Intramolecular Aza‐Wittig Cyclizations of Imides: Direct Access to Pharmaceutically Relevant Amidine Scaffolds

Advanced Synthesis &Catalysis, Volume 368, Issue 16, 18 August 2026.
A metal‐free PIII/PV redox organocatalytic aza‐Wittig reaction enables the efficient cyclization of azide‐functionalized imides into pharmaceutically relevant amidine‐containing heterocycles. Using only 2 mol% of a methanophosphocine catalyst and a Brønsted acid additive, a broad range of substrates is converted in up to 96% yield, including ...
Raphael El Bekri Saudain, Pierre‐Olivier Butin, David Virieux, Tahar Ayad   +3 more
wiley   +1 more source

Design, Synthesis, <i>In Silico</i> ADME, Toxicity Prediction and Molecular Docking Studies of Benzimidazole-Oxadiazole Derivatives for α-Glucosidase and Aldose Reductase Pathways as Potent Anti-Diabetic Agents. [PDF]

Molecules
Işık M, Karakaya A, Çevik UA, Necip A, Duran HE, Çiftçi B, Özkay Y, Kaplancıklı ZA, Beydemir Ş.   +8 more
europepmc   +1 more source