Results 161 to 170 of about 37,139 (276)

Modular Access to α‐Tertiary Amines: Electrochemical Tandem Di‐Functionalization of Olefins With Ammonia Surrogates and Amino Acids

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
A metal‐ and oxidant‐free electrochemical multicomponent di‐functionalization strategy that rapidly converts 1,1‐disubstituted alkenes into α‐tertiary primary amines with simultaneous installation of bio‐relevant sulfur or selenium motifs was devised for late‐stage functionalization. ABSTRACT Quaternary carbon centers, especially those bearing nitrogen,
Adrija Ghosh, Tarun, Sven Erik Peters, Lutz Ackermann, Debasis Banerjee   +4 more
wiley   +2 more sources

Computational, In Vitro, and In Vivo Evaluation of Benzimidazole-Pyrazole Hybrid Scaffolds as Multi-Target Anti-Ulcer Agents. [PDF]

Chem Biodivers
Kharl HAA, Malik A, Nadeem H, Ola MS, Aiman S, Khan AU, Farooq MA, Muzaffar H, Masaud SM.   +8 more
europepmc   +1 more source

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart   +3 more
wiley   +1 more source

Synthesis and Antiparasitic Activities of New Organometallic Derivatives of the Benzimidazole Anthelmintic Drugs. [PDF]

Chembiochem
Ludwig C, Taki AC, Byrne JJ, Mesdom P, Blacque O, Häberli C, Zumkehr T, Scalese G, Pérez-Díaz L, Gambino D, Lundström-Stadelmann B, Keiser J, Gasser RB, Cariou K, Gasser G.   +14 more
europepmc   +1 more source

Searching for Novel COVID19 Treatments: Towards Covalent TMPRSS2 Inhibitors

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
We designed, synthesised, and evaluated new guanidine derivatives as potential covalent inhibitors of TMPRSS2, a key protease for SARS‐CoV‐2 entry. Computational studies showed that some compounds have improved binding over nafamostat. However, experimentally none effectively blocked viral entry in cell assays, indicating further optimisation is needed.
Marco Minneci, Barbara Farkaš, Adeyemi Rahman, Inga Nehlmeier, Amy Eichmann, Stefan Pöhlmann, Isabel Rozas   +6 more
wiley   +1 more source

Dual targeting of VEGFR-2 and FAK kinases by novel benzimidazole-oxadiazole hybrids: a potential approach in cancer therapy. [PDF]

RSC Adv
Abdel-Mohsen HT, Omar MA, Nageeb AM, Abdelsamie AS, El Kerdawy AM.   +4 more
europepmc   +1 more source

Dual Porphyrin Sensitized Photocatalytic System for Visible‐Light‐Driven CO2 Reduction

ChemSusChem, Volume 19, Issue 19, 14 October 2026.
Dual porphyrin–sensitized TiO2 enables efficient visible‐light CO2 reduction by integrating Zn‐porphyrin photosensitization with urea‐functionalized Fe‐porphyrin catalysts. Immobilization enhances charge separation, activity, and durability, while tuning electron donor and proton availability reveals key aspects that influence this catalytic conversion.
Anna Katsari, Emmanouil Nikoloudakis, Georgios Charalambidis, Antonios Iliakis, Fabrice Odobel, Emmanuel Stratakis   +5 more
wiley   +1 more source

Progress in Synthesis and Pharmacology of Telmisartan. [PDF]

Chem Biodivers
Megha, Srivastava R, Singh R.
europepmc   +1 more source

Trifluoromethyl-Benzimidazole-Hydrazone Derivatives as Promising Selective Anticancer Agents: Synthesis, Cytotoxicity, and Molecular Docking Insights. [PDF]

Pharmaceuticals (Basel)
Özil M, Önelge E, Emirik M, Acikalin Coskun K, Tutar Y.   +4 more
europepmc   +1 more source

Benzamides of 2-(aminophenyl)benzimidazoles and 2-(aminophenyl)indoles as Anticancer Scaffolds: Synthesis, In Silico and In Vitro Evaluation. [PDF]

Pharmaceuticals (Basel)
Saeed A, Nadeem H, Malik FP, Paracha RZ, Khan SN.   +4 more
europepmc   +1 more source