Results 71 to 80 of about 17,199 (170)

Unveiling Benzoxazole‐Substituted Thiazolyl‐Pyrazole Derivatives Inducing Apoptosis by Targeting β‐Tubulin and Caspase‐3

ChemMedChem, EarlyView.
BP(1‐6) compounds designed from Benzoxazole and Thiazolyl‐Pyrazole scaffolds exhibited potent antitubulin and caspase‐3 activity in MDA‐MB‐231 cells. BP‐6 notably triggered apoptosis and disrupted cell proliferation. Docking studies validated strong binding affinities of BP‐2 and BP‐6 toward β‐tubulin and caspase‐3, suggesting promising therapeutic ...
Burak Kuzu, Mustafa Cakir, Eda Acikgoz, Mehmet Abdullah Alagoz   +3 more
wiley   +1 more source

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, EarlyView.
Several derivatives incorporating five‐membered aromatic rings are described in this review as bile acid receptor modulators, particularly targeting the farnesoid X receptor and the G protein‐coupled bile acid receptor 1. This review provides a comprehensive analysis of patents and literature that is useful to support researchers in the design of new ...
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

Serious adverse events reported with benzimidazole derivatives: A disproportionality analysis from the World Health Organization's pharmacovigilance database.

PLoS Neglected Tropical Diseases
BackgroundBenzimidazole derivatives are widely used anthelmintic drugs, particularly in mass campaigns for intestinal parasitosis treatment. Despite their generally good safety profile, serious adverse reactions have been reported.
Pamella Modingam, Jean-Luc Faillie, Jérémy T Campillo   +2 more
doaj   +1 more source

Compression‐Induced Amorphization of ZIF‐62 Leading to Formation of Porous Glass: Overcoming the Limitations of Current Methods

Chemistry–Methods, EarlyView.
Nonhydrostatic compression in steps is applied to transform crystalline zeolitic imidazolate framework‐62 into glass at room temperature. This method overcomes the limitations of existing approaches. This research reveals the mechanism of this phase transformation, including modifications in porosity, using various techniques, particularly positron ...
Jaideep Mor, Renjith B. Nelliyil, Ravi Kumar, Amit Verma, Sandeep Kumar Sharma   +4 more
wiley   +1 more source

Post‐Mortem Identification and Toxicological Findings of Fluetonitazepyne and Isotonitazepyne

Drug Testing and Analysis, EarlyView.
In early 2025, five death cases in Finland tested positive for fluetonitazepyne and one for isotonitazepyne in urine drug screening. A peak corresponding to O‐dealkylated fluetonitazepyne, the 4‐OH‐nitazepyne metabolite, was present in all fluetonitazepyne‐positive urine samples and was later used in the identification of isotonitazepynein one fatal ...
Pirkko Kriikku, Anna Pelander, Antti Jylhä, Ilkka Ojanperä   +3 more
wiley   +1 more source

QSAR MODELING OF ANTIBACTERIAL ACTIVITY OF SOME BENZIMIDAZOLE DERIVATIVES [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2011
A quantitative structure-activity relationship (QSAR) study has been carried out for a training set of 12 benzimidazole derivatives to correlate and predict the antibacterial activity of studied compounds against Gram-negative bacteria Pseudomonas ...
SANJA O. PODUNAVAC-KUZMANOVIĆ, DRAGOLJUB D. CVETKOVIĆ   +1 more
doaj  

Challenges and the Way to Improve Lithium‐Ion Battery Technology for Next‐Generation Energy Storage

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Challenges and prospects for lithium‐ion battery. As a forefront energy storage technology, lithium‐ion batteries (LIBs) have garnered immense attention across diverse applications, including electric vehicles, consumer electronics, and medical devices, owing to their exceptional energy density, minimal self‐discharge rate, high open circuit voltage ...
Ashaduzzaman Khan, Harun Al Rashid, Pijush Kanti Roy, Samiul Islam Chowdhury, Sharmin Ara Sathi   +4 more
wiley   +1 more source

Antiproliferative effect of silver compounds containing benzimidazole ring

Trakya University Journal of Natural Sciences
With its significant biological activities, the benzimidazole nucleus is a crucial pharmacophore in medicine. Recent studies have focused on the synthesis and biological activity of benzimidazole compounds.
Senem Akkoç, Buket Banu Özkan, Dilek Bahar   +2 more
doaj   +1 more source

Highly Efficient Simultaneous Photocatalytic Reduction of CO2 and O2 from Air Using Conjugated Microporous Polymers with Ionic Imidazolium Sites

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
In this work, we reported the rational design of two ionic conjugated microporous polymers for efficient simultaneous photocatalytic reduction of CO2 and O2 from air under mild conditions. Efficient photocatalytic reduction of CO2 is crucial to decrease the atmospheric concentration of CO2.
Waner Li, Tingting Zhang, Chunyuan Feng, Mantao Chen, Zhaodi Sun, Eric Storr Sage Handberg, Bo Wang, Lixiang Zhong, Chunhui Dai   +8 more
wiley   +1 more source

[3]Radialene fluorophores with pH‐switchable emission and stable absorption maxima

European Journal of Organic Chemistry, Accepted Article.
We report on the first push‐pull quino [3]radialene fluorescent dye. Here, the novel bis(dicyanomethylene)‐[3]radialene electron acceptor was connected to a benzimidazole donor. With protonation a substantial red‐shift of fluorescence wavelength is observed, while the absorption maximum remains stable.
Jan P. Soyka, J. Felix Witte, Anja Wiesner, Alexander R. Krappe, Dana Wehner, Nicola Alnicola, Beate Paulus, Ute Resch-Genger, Siegfried Eigler   +8 more
wiley   +1 more source