Synthesis and Analgesic Activity of Novel Derivatives of 1,2-Substituted Benzimidazoles
Journal of Chemistry, 2013 A series of novel 2-phenylhydrazinomethyl and 2-(2-hydroxyphenyl)-benzimidazole derivatives substituted at the N1-position of benzimidazole nucleus were synthesized as well as screened for analgesic activity.
Shobhit Srivastava +3 more
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Acta Crystallographica Section E, 2009 The title compound, C24H26N4O4, is a diaza-crown ether encompassing linked phenylpyrazolyl and benzimidazole units that contribute five atoms to the 16-atom ring. The two planar phenylpyrazolyl and benzimidazole units are aligned at an angle of 66.4&#
Joseph Nathan Ghomsi +4 more
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An efficient synthesis, invitro and insilco evaluation of new pyrazole and isoxazole derivatives as anti-inflammatory agents [PDF]
, 2021 343-350The present study is the synthesis of new heterocyclic moieties like pyrazole, isoxazole and thiazole containing benzimidazole nucleus. The title compounds were synthesized from 4-(1H-benzo[d]imidazol-2-yl) oxazol-2-amine.
Merugu, Ramchander +2 more
core
Advanced Intelligent Discovery, EarlyView.Materials informatics and autonomous experimentation are transforming the discovery of organic molecular crystals. This review presents an integrated molecule–crystal–function–optimization workflow combining machine learning, crystal structure prediction, and Bayesian optimization with robotic platforms.
Takuya Taniguchi +2 more
wiley +1 more source
Comprehensive Investigation of Benzimidazolium Derivatives Through Synthesis, Characterization, Cytotoxicity Activity, Immunocytochemistry, and ADME and Toxicity Analyses. [PDF]
ChemistryOpenThree benzimidazolium derivatives bearing fluoro, chloro, and methoxy substituents are synthesized and evaluated for anticancer activity. Compound 2b shows the highest antiproliferative activity and induces apoptosis through caspase‐3 activation and PARP1 cleavage. In this study, three novel benzimidazolium derivatives (2a–c) bearing 4‐fluoro, 3‐chloro,
Dilek G, Akkoc S.
europepmc +2 more sources
Synthesis and second-order nonlinear optical properties of new chromophores containing benzimidazole, thiophene and pyrrole heterocycles [PDF]
, 2007 A new series of thermally stable benzimidazole-based nonlinear optical (NLO) chromophores 4-5 has been developed. These chromophores possess a thienylpyrrolyl pi-conjugated system attached to functionalized benzimidazole heterocycles.
Batista, Rosa Maria Ferreira +3 more
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Synthesis of Benzimidazole-Sulfonyl Derivatives and Their Biological Activities
Biochemistry Research International, 2022 Currently, the synthesis of new compounds with potential bioactivities has become a central issue in the drug discovery arena. Among these new compounds, benzimidazole-sulfonyl scaffolds have vital applications in the fields of pharmaceuticals industries.
Endale Mulugeta, Yoseph Samuel
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Advanced systems for the rapid detection of anthelmintic drugs in food [PDF]
, 2011 Several surface plasmon resonance (SPR) biosensor assays were developed and validated for the detection of anthelmintic veterinary drugs in liver tissue and milk using a QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) extraction procedure. The
Keegan, Jemma Louise
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Research Progress on Benzimidazole Fungicides: A Review
MoleculesBenzimidazole fungicides are a class of highly effective, low-toxicity, systemic broad-spectrum fungicides developed in the 1960s and 1970s, based on the fungicidal activity of the benzimidazole ring structure.
Song Bai +8 more
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1-[2-(3,4-Dichlorobenzyloxy)-2-phenylethyl]-1H-benzimidazole
Acta Crystallographica Section E, 2008 In the molecule of the title compound, C22H18Cl2N2O, the planar benzimidazole ring system is oriented with respect to the phenyl and dichlorobenzene rings at dihedral angles of 12.73 (3) and 36.57 (4)°, respectively.
Özden Özel Güven +3 more
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