Results 71 to 80 of about 37,139 (276)

Synthesis, Characterization and Biological Evaluation of 1, 2-Disubstituted Benzimidazole Derivatives using Mannich Bases

open access: yesE-Journal of Chemistry, 2010
The ring system in which a benzene ring is fused to the 4,5-positions of imidazole is designated as benzimidazole. Condensations of 2-substituted benzimidazole derivatives were synthesized by different carboxylic acids using Mannich base and anti ...
B. Anil Reddy
doaj   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

open access: yesAnimal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen   +5 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum   +5 more
wiley   +1 more source

SYNTHESIS AND BIOLOGICAL EVALUATION OF BENZIMIDAZOLE DERIVATIVES AS ANTIMICROBIAL AGENTS [PDF]

open access: yes, 2019
Objective: The present study aims to synthesize and biological evaluation of benzimidazole derivatives as antimicrobial agents. Methods: 2-Methylbenzimidazole react with ethyl-chloroacetate gives N1-Ethylacetate-2-methyl-benzimidazole (1), which on ...
SHINDE, VANDANA BABAN   +1 more
core   +1 more source

Dibromido[1,1′-dibutyl-2,2′-(pentane-1,1-diyl)di-1H-benzimidazole]copper(II)

open access: yesActa Crystallographica Section E, 2010
In the title compound, [CuBr2(C27H36N4)], the CuII ion exhibits a distorted tetrahedral coordination geometry provided by two bromide ions and by chelation of two imine N-atom donors from a bis(benzimidazole) ligand.
Robert T. Stibrany, Joseph A. Potenza
doaj   +1 more source

p-Nitrophenyl ester of (diphenylphosphoryl)acetic acid as a reagent for the synthesis of 2-(phosphorylmethyl)benzimidazole

open access: yesЖурнал органічної та фармацевтичної хімії, 2020
Aim. To expand the synthetic potential of the activated esters of diphenylphosphorylacetic acid for the synthesis of phosphorylated benzimidazoles. Results and discussion.
Oleksandra O. Chaikovska   +3 more
doaj   +1 more source

Acute toxic leucoencephalopathy following protonitazene ingestion

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Background Distribution of illicit counterfeit alprazolam containing the highly potent synthetic opioid‐receptor agonist protonitazene recently resulted in a number of severe overdoses in Ireland. We report three cases that presented to our hospital, within 6 weeks of one another, following ingestion of illicitly‐sourced alprazolam.
Ruadhan O'Laoi   +5 more
wiley   +1 more source

Polysulfones tethered with benzimidazole

open access: yes, 2006
Benzimidazole units have been grafted onto a polysulfone (PSU) backbone via long alkyl thio–ether chains using a two-step procedure. In the first step, lithiated PSU was reacted with 10-undecenoyl chloride to graft PSU with undecenoyl side chains.
Josefsson, Karl   +3 more
core   +2 more sources

Using allele-specific oligonucleotide probes to characterize benzimidazole resistance in Rhynchosporium secalis

open access: yes, 1995
Benzimidazole fungicides are important mixture components in strategies to combat fungicide resistance in Rhynchosporium secalis Davis. To monitor the performance of these strategies, a rapid, accurate assay has been developed to detect point mutations ...
Hollomon, D. W.   +4 more
core  

Accelerating green heterocyclic synthesis: Convergence of AI, automation, and sustainable chemistry

open access: yesBulletin of the Korean Chemical Society, EarlyView.
Green heterocyclic synthesis and data‐driven tools such as AI, high‐throughput experimentation, continuous flow, and self‐driving laboratories have developed largely in parallel. This review connects them and asks how green metrics such as E‐factor and PMI might serve as explicit optimization targets rather than post‐hoc measures, toward sustainable ...
Noor Aisyah Ahmad Shah   +8 more
wiley   +1 more source

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