Results 211 to 220 of about 26,682 (264)
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The metabolism of benzimidazole anthelmintics
Parasitology Today, 1990The benzimidazole carbamates are important broad-spectrum drugs for the control of helminth parasites in mammals. David Gottschall, Vassilios Theodorides and Richard Wang explain that the metabolism of these compounds depends heavily on the substituent present on carbon-5 of the benzimidazole nucleus and involves a wide variety of reactions.
D W, Gottschall +2 more
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Biochemistry of benzimidazole resistance
Acta Tropica, 1994Heavy reliance on the benzimidazole (BZ) anthelmintics since their introduction in the 1960's for the control of gastrointestinal parasites of livestock has led to widespread BZ resistance in target parasite species. The BZs exert their primary action by binding to tubulin, the major protein component of microtubules.
E, Lacey, J H, Gill
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Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin
Biochimica et Biophysica Acta (BBA) - General Subjects, 1978The binding and inhibitory properties of 11 benzimidazoles for bovine brain tubulin were investigated. The effects of the benzimidazoles on the initial rates of microtubule polymerization were determined by a turbidimetric assay. The median inhibitory concentrations (I50) for nocodazole, oxibendazole, parbendazole, mebendazole and fenbendazole ranged ...
P A, Friedman, E G, Platzer
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Benzimidazoles in a wormy world
Parasitology Today, 1990The problem of helminth infection is vast by anyone’s reckoning and is of equal interest to the veterinary surgeon and the clinician. To say that helminths are ubiquitous is almost an understatement: as parasites of livestock and humans, they represent the single most important group of infections on the planet, although many separate species are ...
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J. Chem. Soc., Chem. Commun., 1986
[Fe2S2L2]2– complexes co-ordinated by the mixed-donor N–S, N–O, or N–N ligands L1–L4 are characterised by electronic and n.m.r. spectroscopy and shown to undergo one-electron reduction to the corresponding trianions with e.s.r. spectra exhibiting a range of g-tensor values which are compared with those for [2Fe–2S]+ proteins of the Rieske type.
Peter Beardwood, John F. Gibson
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[Fe2S2L2]2– complexes co-ordinated by the mixed-donor N–S, N–O, or N–N ligands L1–L4 are characterised by electronic and n.m.r. spectroscopy and shown to undergo one-electron reduction to the corresponding trianions with e.s.r. spectra exhibiting a range of g-tensor values which are compared with those for [2Fe–2S]+ proteins of the Rieske type.
Peter Beardwood, John F. Gibson
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2000
Abstract A Acute encephalopathy (confusion, hallucinations, seizures) B Headache Two substituted 1,3-benzodiazoles (benzimidazoles), thia bendazole and mebendazole, serve as broad-spectrum ant helmintics. Niridazole, formerly a treatment for schistoso miasis, has been supplanted by more effective agents.
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Abstract A Acute encephalopathy (confusion, hallucinations, seizures) B Headache Two substituted 1,3-benzodiazoles (benzimidazoles), thia bendazole and mebendazole, serve as broad-spectrum ant helmintics. Niridazole, formerly a treatment for schistoso miasis, has been supplanted by more effective agents.
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Mode of action of benzimidazoles
Parasitology Today, 1990Benzimidazoles represent the only class of truly broad-spectrum anthelmintics, however, they also show activity against fungi and mammalian cells. This raises the question as to why benzimidazoles can selectively kill helminths and yet exhibit little or no mammalian toxicity.
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Benzimidazoles: Veterinary uses
Parasitology Today, 1990Benzimidazoles are valued for use against helminth infections in domestic animals. Here, Bill Campbell discusses efficacy, dosages, methods of administration and the species of parasite against which they are applied.
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Quinoxaline-benzimidazole rearrangement in the synthesis of benzimidazole-based podands
Russian Journal of Organic Chemistry, 2006Alkylation of 3-benzoylquinoxalin-2(1H)-one with 1,5-dibromo-3-oxapentane, 1,8-dibromo-3,6-dioxaoctane, and α,ω-dihaloalkanes with different lengths of the polymethylene chain gave the corresponding quinoxaline podands. In the reaction with 1,2-dibromoethane, the N,O-rather than N,N′-alkylation product was obtained.
V. A. Mamedov +4 more
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Journal of the American Veterinary Medical Association, 1987
J P, Tritschler +2 more
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J P, Tritschler +2 more
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