Results 91 to 100 of about 12,752 (178)

Cerebral trypanosomiasis and AIDS

Arquivos de Neuro-Psiquiatria, 2002
A 36 year-old black female, complaining of headache of one month's duration presented with nausea, vomiting, somnolence, short memory problems, loss of weight, and no fever history. Smoker, intravenous drugs abuser, promiscuous lifestyle.
Antunes Apio Claudio Martins, Cecchini Felipe Martins de Lima, Bolli Fernando von Bock, Oliveira Patricia Polanczyk de, Rebouças Ricardo Gurgel, Monte Thais Lampert, Fricke Daniele   +6 more
doaj  

Effects of Free and Nanoencapsulated Benznidazole in Acute Trypanosoma cruzi Infection: Role of Cholinergic Pathway and Redox Status

Pharmaceuticals
Background/Objectives: The Trypanosoma cruzi infection promotes an intense inflammatory process that affects several tissues. The cholinergic system may exert a regulatory immune response and control the inflammatory process. This study aimed to evaluate
Aniélen D. da Silva, Mateus Fracasso, Nathieli B. Bottari, Taís V. Palma, Ana M. Engelmann, Milagros F. V. Castro, Charles E. Assmann, Vitor Mostardeiro, Karine P. Reichert, Jelson Nauderer, Marcelo L. da Veiga, Maria Izabel U. M. da Rocha, Luiz Claudio Milleti, Gabriella B. das Neves, Samanta Gundel, Aline F. Ourique, Silvia G. Monteiro, Vera M. Morsch, Maria Rosa Chitolina, Aleksandro S. Da Silva   +19 more
doaj   +1 more source

Mother-to-Child Transmission of Congenital Chagas Disease, Japan

Emerging Infectious Diseases, 2014
We report a patient with congenital Chagas disease in Japan. This report reemphasizes the role of neglected and emerging tropical diseases in the era of globalization. It also indicates the need for increased vigilance for detecting Chagas disease in non–
Kazuo Imai, Takuya Maeda, Yusuke Sayama, Kei Mikita, Yuji Fujikura, Kazuhisa Misawa, Morichika Nagumo, Osamu Iwata, Takeshi Ono, Ichiro Kurane, Yasushi Miyahira, Akihiko Kawana, Sachio Miura   +12 more
doaj   +1 more source

Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations

Memorias do Instituto Oswaldo Cruz, 2018
Eukaryotic initiation factor 5A (eIF5A) is a conserved protein with an essential role in translation elongation. Using one and two-dimensional western blotting, we showed that the eIF5A protein level was 2-fold lower in benznidazole (BZ)-resistant (BZR ...
Douglas de Souza Moreira, Ana Paula Duarte, Fabiano Sviatopolk Mirsky Pais, Rosiane Aparecida da Silva-Pereira, Alvaro José Romanha, Sergio Schenkman, Silvane Maria Fonseca Murta   +6 more
doaj   +1 more source

Drug Resistance in Eukaryotic Microorganisms [PDF]

, 2016
Eukaryotic microbial pathogens are major contributors to illness and death globally. Although much of their impact can be controlled by drug therapy as with prokaryotic microorganisms, the emergence of drug resistance has threatened these treatment ...
A Abdolrasouli, A Cassone, A Chowdhary, A Ecker, A Heinberg, A Kulshrestha, A Mbengue, A Mukherjee, A Selmecki, A Selmecki, A Trochine, AC Coelho, AF Cowman, AF Cowman, AH Fairlamb, AH Fairlamb, AJ Kazibwe, AM Abd-Alla, AM Dondorp, AM Mejia, AY Sokolova, B Chawla, B Gourbal, B Zingales, BD Alexander, BJ Kullberg, BK Kubata, BM Mony, BS Hall, BS Hall, BS McGwire, C Amaratunga, C Amaratunga, C Brochu, C Costa, C Mathieu, C Sisowath, C Wongsrichanalai, CA Morillo, CD Goodman, CF Oliva, CP Sanchez, CP Sanchez, D Begolo, D Rojo, DA Fidock, DS Guttery, DS Perlin, DW Denning, E Castanys-Munoz, E Chatelain, E Kussell, E Matovu, E Shor, E Snelders, E Snelders, E Vermeulen, E Wang, F Ariey, F Nosten, FC Odds, FE Graf, FE Graf, FJ Perez-Victoria, FJ Perez-Victoria, FJ Perez-Victoria, FM Fernandez, G Awasthi, G Blum, G Priotto, GA Canuto, GA Pankey, GM Nayyar, GW Rose, H Noedl, HL Callahan, HM Andrade, HY Sun, I Keren, I Molina, IH Cheeseman, IM Vincent, IM Vincent, IM Vincent, J Hemingway, J Robays, J Song, J Straimer, J Yuan, JA Urbina, JA Urbina, JC Dias, JC Dias, JC Munday, JC Wootton, JI Manzano, JL Nishikawa, JM Perez-Victoria, JR Franco, JW van der Linden, K El Fadili, K Lewis, K Seifert, KC Gray, KJ Kwon-Chung, KW Dantzler, L Denoeud-Ndam, L Glover, LE Cowen, LE Cowen, M Berg, M Ghorbal, M Maharjan, M Manske, M Plourde, M Rakotomanga, M Rakotomanga, M Venkatesan, M Woolhouse, M Woolhouse, MA Pfaller, MB Rogers, MC Brotherton, MD LaFleur, MD LaFleur, MK Kinga, MK Laufer, MR Perry, MR Perry, MR Perry, MT Duraisingh, MT Ferdig, N Baker, N Biyani, N Marquis, N Regev-Rudzki, N Rovira-Graells, NJ White, NR Cohen, NS Carter, O Epaulard, O Miotto, P Baiocco, P Maser, P Shaked-Mishan, P Vandeputte, P Wang, PE Verweij, PJ Hotez, PK Fyfe, PL Olliaro, PP Pyana, PY Mantel, R Kumar, R Mukhopadhyay, R Prasad, RD Cannon, S Alsford, S Decuypere, S Decuypere, S Dey, S Dey, S Imhof, S Kucharikova, S Leroux, S Mandal, S Mok, S Patterson, S Pelleau, S Pulcini, S Rijal, S Sundar, S Sundar, S Takala-Harrison, S Wyllie, S Wyllie, S Wyllie, S Wyllie, SA Flowers, SC Welburn, SD Singh, SE Kidd, SG Valderramos, SK Katiyar, SMF Murta, SR Meshnick, SR Wilkinson, TE Wellems, TE Wellems, TPC Dorlo, V Lutje, W Peters, Y Sterkers, Y Zhou   +193 more
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Benznidazole levels in blood vary with age in rats

Memorias do Instituto Oswaldo Cruz, 2011
Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity.
Romina Fernanda Bulffer, José Alberto Castro, Silvia Laura Fanelli   +2 more
doaj   +1 more source

Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development [PDF]

, 2014
Advocacy for better drugs and access to treatment has boosted the interest in drug discovery and development for Chagas disease, a chronic infection caused by the genetically heterogeneous parasite, Trypanosoma cruzi.
Araujo-Junior, Adalberto M., Chatelain, Eric, Franco, Caio H., Freitas-Junior, Lucio H., Giardini, Miriam A., Kim, Hwayoung, Moraes, Carolina B., Schenkman, Sergio   +7 more
core   +1 more source

A serological, parasitological and clinical evaluation of untreated Chagas disease patients and those treated with benznidazole before and thirteen years after intervention

Memorias do Instituto Oswaldo Cruz, 2013
The etiological treatment of Chagas disease is recommended for all patients with acute or recent chronic infection, but controversies remain regarding the benefit of chemotherapy and interpretations of the parasitological cure after etiological treatment.
Girley Francisco Machado-de-Assis, Glaucia Alessio Diniz, Roberto Araujo Montoya, Joao Carlos Pinto Dias, Jose Rodrigues Coura, George Luiz Lins Machado-Coelho, Pedro Albajar-Vinas, Rosalia Morais Torres, Marta de Lana   +8 more
doaj   +1 more source

Triclosan-caffeic acid hybrids: Synthesis, leishmanicidal, trypanocidal and cytotoxic activities [PDF]

, 2017
The synthesis, cytotoxicity, anti-leishmanial and anti-trypanosomal activities of twelve triclosan-caffeic acid hybrids are described herein. The structure of the synthesized products was elucidated by a com- bination of spectrometric analyses.
Agut, Raúl, Carda, Miguel, Cardona G, Wilson I, García, Elisa, Otero, Elver, Palacios, Génesis, Robledo, Sara M., Vélez, Iván D., Yepes, Lina M.   +8 more
core   +1 more source

The BENEFIT trial: testing the hypothesis that trypanocidal therapy is beneficial for patients with chronic Chagas heart disease

Memorias do Instituto Oswaldo Cruz, 2009
Among the pathophysiological derangements operating in the chronic phase of Chagas disease, parasite persistence is likely to constitute the main mechanism of myocardial injury in patients with chronic chagasic cardiomyopathy. The presence of Trypanosoma
J Antonio Marin-Neto, Anis Rassi Jr, Alvaro Avezum Jr, Antonio C Mattos, Anis Rassi   +4 more
doaj   +1 more source